Abstract:
:mRNA prepared from rat small intestine was injected into Xenopus oocytes. The injected oocytes showed a clear electrical response to D-glucose (Glu) in the form of membrane depolarization and conductance increase, while none was shown to D-fructose. The membrane electrical response of the injected oocytes evoked by Glu followed the Michaelis-Menten type kinetics and was dependent on the membrane potential of the oocyte. Replacing the Na+ of the bathing buffer with choline+ resulted in no response to Glu. Thus, a Glu transport system coupled to a Na+ gradient was expressed in Xenopus oocytes by injecting mRNA from rat small intestine.
journal_name
Brain Resjournal_title
Brain researchauthors
Aoshima H,Ishii H,Anan Mdoi
10.1016/0169-328x(87)90033-7subject
Has Abstractpub_date
1987-09-01 00:00:00pages
263-7issue
3eissn
0006-8993issn
1872-6240journal_volume
388pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03125-0
更新日期:2001-12-07 00:00:00
abstract::Diphtheria toxin (DTX) kills cells by inactivating ribosomal translocation and when used to retrogradely intoxicate cat intercostal motoneurones produces marked morphological alterations in Nissl bodies, including those specifically sited postsynaptic to C-type axon terminals. Here, qualitative examinations of 'intoxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90302-r
更新日期:1990-02-12 00:00:00
abstract::Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]stryc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90160-2
更新日期:1980-12-08 00:00:00
abstract::The aim of the present study was to investigate the effects of ischemic preconditioning on infarct volume in a rat model of subdural hematoma (SDH). Ischemic preconditioning was induced by 15 min transient middle cerebral artery (MCA) occlusion followed 3 days later by the injection of 300 microl of autologous venous ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03406-0
更新日期:2002-03-15 00:00:00
abstract::There is an abundance of evidence suggesting that the area postrema (AP) is involved in the central actions of arginine-vasopressin (AVP) and angiotensin II (Ang II) on cardiovascular regulation. Furthermore, recent studies have shown that activation of the AP facilitates the response of nucleus tractus solitarius (NT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91323-4
更新日期:1994-06-06 00:00:00
abstract::The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 microM was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3H]dopamine uptake. Moreover, DDC 1 microM greatly potentiated cell death induced ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01457-s
更新日期:1995-03-13 00:00:00
abstract::Horseradish peroxidase (HRP) injected into developing limb buds of Xenopus laevis tadpoles is carried by retrograde axonal transport to the somata of motoneurones in the ventral horn. Small injection of 10% HRP were found to remain well localised to specified sites in the limb bud. Two types of labelled cells were fou...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)91067-8
更新日期:1977-10-07 00:00:00
abstract::Decision making is commonly conceived to reflect the interplay of mutually antagonistic systems: executive processes must inhibit affective information to make adaptive choices. Consistent with this interpretation, prior studies have shown that the dorsolateral prefrontal cortex (dlPFC) is activated by executive proce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.04.026
更新日期:2011-06-13 00:00:00
abstract::The present work evaluated the reproducibility and variance of the cerebral blood flow (CBF) response to natural whisker stimulation in the barrel cortex of awake behaving mice. The animal was placed on an air float ball that allowed the animal to walk, while the head of the animal was fixed in a custom-made stereotac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.11.007
更新日期:2011-01-19 00:00:00
abstract::38 primary afferents originating from de-efferented cat tibialis anterior muscle spindles were investigated. Ramp-and-hold stretches of the host muscle were performed with a varying amount of muscle pre-stretch while recording the primary afferent discharges. From the discharge responses an interspike interval functio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91650-h
更新日期:1993-05-28 00:00:00
abstract::Descending protocerebral neurons in the male silkworm moth brain responding to the sexual pheromone (Bombykol) were identified. The neurons responded well with a tonic type of response and the high-frequency spikes evoked continued even after the end of the stimulus. Characteristics of the dose-response curves of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90885-1
更新日期:1986-07-09 00:00:00
abstract::Rats were trained on a radial maze and then given electrolytic lesions of the MS followed by a single intraseptal injection of 5 micrograms of NGF. Three days later they were re-tested on the maze. They were also post-operatively tested for hyperemotionality. MS lesions severely impaired performance on the radial maze...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00242-i
更新日期:1995-05-08 00:00:00
abstract::Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the control of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00743-3
更新日期:1996-10-28 00:00:00
abstract::During functional spinal neural network activity motoneurons receive massive synaptic excitation and inhibition, and their membrane conductance increases considerably - they are switched to a high-conductance state. High-conductance states can substantially alter response properties of motoneurons. In the present stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.07.030
更新日期:2016-10-01 00:00:00
abstract::Many lines of evidence support the importance of the nucleus accumbens (NAC) for ethanol-reinforced behavior. The nature of the neuronal activity that occurs in this region during ethanol self-administration is not known. We recorded from ensembles of single-units primarily located within the shell of the NAC during o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01245-1
更新日期:1999-01-30 00:00:00
abstract::The olivary pretectal nucleus is a primary visual centre sensitive to luminance changes. It is involved in the pupillary light reflex, the consensual pupillary light reflex and related reflexes, such as the lid closure reflex whereby pupillary constriction takes place. Since the olivary pretectal nucleus is a small nu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00497-e
更新日期:1995-08-07 00:00:00
abstract::The effect of chronic ethanol administration on the density of basket cells in the dentate gyrus of mice selectively bred for their sensitivity to acute ethanol exposure (long-sleep, LS and short-sleep, SS) was assessed in two experiments. In addition, the effect of chronic ethanol on the density of dentate granule ce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90369-1
更新日期:1988-09-20 00:00:00
abstract::Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats. The goal of this study was to determine whether lithium could potentiate pilocarpine-induced seizures in developing animals. Behavioral, electroencephalographic (EEG), and histopathological changes induced by systemic admin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(10)80015-0
更新日期:1992-06-26 00:00:00
abstract::Intracellular recordings of the spontaneous activity were obtained from neurons in long-term cultures from the area of the supraoptic nucleus of rats. The effects of various substances known from in situ studies to cause vasopressin release were analyzed. Application of nicotine or acetylcholine induced a transition f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90174-2
更新日期:1980-07-14 00:00:00
abstract::The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.05.043
更新日期:2013-08-02 00:00:00
abstract::A single electrode voltage clamp was used to examine the prolonged hyperpolarizing afterpotential (PHA) which accompanies photoconversion of a substantial fraction of rhodopsin (lambda max = 500 nM) to metarhodopsin (lambda max = 575 nM) in distal photoreceptor cells in the retina of the bay scallop, Pecten irradians....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90539-x
更新日期:1982-05-13 00:00:00
abstract::The action of the epileptogenic agent pentylenetetrazol (PTZ) on a cloned potassium channel of the rat brain was studied. The Kv1.1 channel was expressed in oocytes of Xenopus laevis and potassium currents were investigated in outside-out and inside-out membrane patches. The results show that PTZ increased the multi-c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00181-3
更新日期:1996-05-25 00:00:00
abstract::The hypothesis that glutamate is the afferent transmitter in the acoustico-lateralis receptors was examined in Plotosus electroreceptors. JSTX , a spider toxin known to specifically block glutamate receptors, irreversibly abolished afferent impulse discharges induced by iontophoretically applied glutamate, whereas tho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91357-x
更新日期:1984-05-21 00:00:00
abstract::A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03282-1
更新日期:2002-10-25 00:00:00
abstract::The specific benzodiazepine antagonist, Ro14-7437, in nanomolar concentrations, caused depolarization, increased spontaneous spiking, and conductance decrease when applied to CA1 cells in vitro. These effects were resistant to intracellularly injected Cl- ions or synaptic blockade by TTX, were prevented in Ca2+-free m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91370-7
更新日期:1983-07-18 00:00:00
abstract::Spatial neglect may involve neglect dyslexia resulting in a failure to identify words or parts of words in the contralesional hemispace. The present study explored a well-documented dissociation in neglect dyslexics' word processing, i.e. impaired reading aloud in the presence of good lexical decision performance for ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.069
更新日期:2008-01-16 00:00:00
abstract::Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep. In the absence of stressors, CRH contributes to the regulation of spontaneous waking. We examined the effects of CRH and astressin (AST), a non-speci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.007
更新日期:2008-01-23 00:00:00
abstract::This study determined whether macrophage inflammatory protein-1beta (MIP-1beta) plays a role in the hyperthermia caused by prostaglandin E2 (PGE2) given intracerebroventricularly (i.c.v.) in the rat. In these experiments, anti-murine MIP-1beta antibody (anti-MIP-1beta) was micro-injected in the anterior hypothalamic, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01362-5
更新日期:1997-02-14 00:00:00
abstract::An extensive mapping of the caudate-putamen in rat for intracranial self-stimulation (ICS) site was undertaken to provide addtional support for the role of dopamine in brain-stimulation reward. Eight-seven per cent of the placements in the neostriatum supported ICS, with self-stimulation rates greater than 250/15 min ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90615-6
更新日期:1976-03-12 00:00:00
abstract::Previous studies have demonstrated that postnatal (days 2-29 of life) administration of lead (200 mg/kg/day by gavage) to Long-Evans rats caused permanent increases in lithium-induced polydipsia (LIP). These lead-induced increases in LIP were apparently not of renal origin, did not occur in animals treated with lead a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90570-5
更新日期:1984-04-16 00:00:00