Abstract：
:Spontaneous alternation which is disrupted by lesion of septal dopaminergic (DA) afferents was chosen as a behavioral marker for the study of functional interactions between DA and noradrenergic (NA) innervation of the lateral septum. Three groups of rats were studied: a solvent group which received only vehicle injection, and two lesioned groups, one with DA lesion and the second with simultaneous DA + NA lesion of the septal innervation. DA lesion was produced by infusing 6-hydroxydopamine (6-OHDA) into the lateral septum after pretreatment with desmethylimipramine (DMI) injected intraperitoneally. The DA + NA lesion was produced by infusing 6-OHDA without DMI pretreatment. The lesion of DA innervation alone led to a disturbance of alternation behavior in a Y-maze, but performance was not affected by the combined DA + NA lesion. The group with septal DA lesion was then injected with 6-OHDA into the pedunculus cerebellaris superior (PCS) in order to destroy NA efferents from the locus coeruleus. The two other groups were sham-operated. After post-operative recovery, the rats were retested for spontaneous alternation. The rats with the PCS NA lesion subsequent to the DA septal lesion displayed normal alternation behavior. Their performance was not different from that of animals with both NA and DA lesions in the septum. Thus the NA lesion appears to prevent the alternation deficits induced by the DA septal lesion, and also abolishes the deficits induced by the prior DA lesions. These results may have therapeutic implications.
journal_name
Brain Resjournal_title
Brain researchauthors
Taghzouti K,Le Moal M,Simon Hdoi
10.1016/0006-8993(91)90669-msubject
Has Abstractpub_date
1991-06-21 00:00:00pages
124-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90669-Mjournal_volume
552pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:This work describes the change in an active electrogenesis of the command neurons responsible for defensive closure of a snail's pneumostome during elaborating, extinction and restoration of a classical conditioned defensive reflex to a tactile stimulus. Tactile stimulations applied to different parts of a snail's bod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91453-l
更新日期：1992-11-06 00:00:00
abstract：:The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01112-2
更新日期：1996-12-16 00:00:00
abstract：:Neuropeptide K (NPK), a member of the kassinin-like tachykinin family, is contained in the rat hypothalamus and is known to stimulate pituitary ACTH release. The intraperitoneal bolus administration of NPK dose-dependently enhanced corticosterone blood level not only in intact rats, but also in hypophysectomized/ACTH ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91185-1
更新日期：1994-10-24 00:00:00
abstract：:The subfornical organ, along with other regions of the lamina terminalis, may contain osmoreceptors and is likely to be a site of action of blood-borne angiotensin II. The neural pathways by which these stimuli lead to vasopressin secretion, have been suggested to extend from the subfornical organ to hypothalamic site...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90708-4
更新日期：1991-08-30 00:00:00
abstract：:The purpose of this study was to investigate the influence of different adenosine triphosphate (ATP) concentrations (ranging from 400 nM to 250 microM) on hippocampal potentials recorded from pyramidal neurons. ATP applied at a concentration of 400 nM induced a 100% increase in the size of the population spike (potent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90070-x
更新日期：1989-07-10 00:00:00
abstract：:Combined amylin+leptin (AMN+LEP) can reduce diet induced obesity and is very effective in combating LEP resistance. The purpose of this study was to evaluate the effect of AMN+LEP on central histaminergic signaling in lean and obese rats. Male rats were administered LEP (300 μg/kg/d), AMN (100 μg/kg/d), AMN+LEP or veh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.022
更新日期：2012-03-09 00:00:00
abstract：:A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneuro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03048-1
更新日期：2001-01-19 00:00:00
abstract：:The analysis of the dynamic properties of epileptiform activity in vitro has led to a better understanding of the time course of neural synchronization and seizure states. Nonlinear analysis is thus potentially useful for the prediction of seizure onset. We have used nonlinear analysis methods to investigate the devel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03166-8
更新日期：2001-02-02 00:00:00
abstract：:Isolated brain capillary endothelial cells contain high activity levels of the blood-brain barrier (BBB) marker enzymes gamma-glutamyltranspeptidase (gamma-GT) and alkaline phosphatase (ALP). In primary culture the activities of these specific enzymes decrease with increasing cell proliferation to a constant low value...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91425-g
更新日期：1990-04-30 00:00:00
abstract：:The mesocorticolimbic circuitry has been implicated in the pathophysiology of several neuropsychiatric syndromes like chronic pain and addiction. The aim of this study was to evaluate the effects of dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on sensorimotor behaviors and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02988-3
更新日期：2003-08-15 00:00:00
abstract：:Rats provided limited daily access to cocaine (1 h) maintain stable levels of drug self-administration over time while those switched to longer access (6 h or more) exhibit escalating patterns of drug intake. These results are reminiscent of human recreational and compulsive drug-taking behavior, respectively. We foun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.053
更新日期：2004-01-02 00:00:00
abstract：:Depolarizing actions of 4 conformationally restricted L-glutamate analogues, (2S,3S,4S) isomer (L-CCG-I), (2S,3R,4R) isomer (L-CCG-II), (2S,3S,4R) isomer (L-CCG-III) and (2S,3R,4S) isomer (L-CCG-IV) of L-alpha-(carboxycyclopropyl)-glycine (L-CCG), were investigated in the isolated rat spinal cord by extracellular reco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90207-2
更新日期：1989-02-20 00:00:00
abstract：:Excitatory actions of acromelic acid were investigated in the isolated newborn rat spinal cord. Test compounds were added to the perfusing fluid and the responses were recorded from the ventral root extracellularly. Acromelic acid caused a depolarizing response in a dose-dependent manner and the depolarizing activity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90456-8
更新日期：1988-12-06 00:00:00
abstract：:The purpose of this study was to ascertain whether visual acuity or contrast sensitivity function (CSF) is proportional to visual cortical function based on fMRI volume and level of activation or Z-score. Forced choice procedures were utilized to measure the monocular log minimal angle of resolution (logMAR) visual ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.082
更新日期：2011-01-07 00:00:00
abstract：:The drug 6-hydroxydopamine (6-OHDA) has been reported to reduce hypothalamic norepinephrine (NE) content after administration into the lateral ventricle without altering the dopamine content of tubero-infundibular neurons. Serum prolactin levels in male rats injected with 2 X 250 mug 6-OHDA were significantly higher t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90647-8
更新日期：1976-03-05 00:00:00
abstract：:Repeated odorant or electrical stimulation of the frog olfactory nerve leads to long-lasting reduction of excitability of the receptor neurons. In the turtle olfactory nerve electrical stimulation causes an increase in extracellular potassium concentration due to the efflux of potassium from active axons. Elevated pot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90340-h
更新日期：1990-12-24 00:00:00
abstract：:Both glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) can protect nigrostriatal dopaminergic neurons from neurotoxins in rodent and monkey models of Parkinson's disease (PD). These two neurotrophic factors are usually tested individually. This study was designed to compar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.072
更新日期：2005-08-09 00:00:00
abstract：:The purpose of the present study was to determine the effects of chronic (2-month) estradiol (E2) treatment on cholinergic function in the frontal cortex, hippocampus and hypothalamus of the female rat. Chronic E2 treatment selectively increased choline acetyltransferase (ChAT) activity in the frontal cortex and decre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90871-8
更新日期：1990-08-20 00:00:00
abstract：:The distribution of the regulatory (RII beta) subunits of type II cAMP-dependent protein kinase in cortical and subcortical areas was examined in human control and Alzheimer's disease (AD) brains. Four monoclonal antibodies generated against bovine brain RII, which cross-reacted with human brain RII beta, detected RII...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90230-7
更新日期：1992-04-24 00:00:00
abstract：:The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. The RAGE-ligand interaction has a putative role in a range of chronic disorders and is also known to contribute to both inflammatory/degenerative processes as well as regenerati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04149-5
更新日期：2003-03-21 00:00:00
abstract：:Fractionated partial or whole-brain irradiation (fWBI) is a widely used, effective treatment for primary and metastatic brain tumors, but it also produces radiation-induced brain injury, including cognitive impairment. Radiation-induced neural changes are particularly problematic for elderly brain tumor survivors who ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.034
更新日期：2011-04-18 00:00:00
abstract：:Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91813-v
更新日期：1990-11-12 00:00:00
abstract：:Numerous studies have suggested that nitric oxide (NO) in the nucleus tractus solitarii (NTS) participates in modulating cardiovascular function. Nitric oxide synthase (NOS), the enzyme responsible for synthesis of NO, exists in 3 isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). Althoug...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.057
更新日期：2007-09-26 00:00:00
abstract：:Using quantitative receptor radioautography, binding sites for the 'peripheral-type' benzodiazepine receptor ligand [3H]PK 11195 were studied in rats 4 week after end-to-side portacaval anastomosis and in sham-operated controls. Portacaval anastomosis resulted in region-selective increases in density of [3H]PK 11195 b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91222-z
更新日期：1992-07-10 00:00:00
abstract：:Previous studies have shown behavioral changes in pre- and postnatal rats exposed to morphine before and during gestation. The present study has attempted to discover morphological correlates of these changes in the fetal rat spinal cord. Pregnant Wistar rats were injected subcutaneously on days 12-18 of gestation wit...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1980-11-24 00:00:00
abstract：:Although dendritic release was first proposed in the 1970s, the mechanism of release is still subject to debate. We have used in vivo microdialysis to study the acute effects of botulinum toxin A, B and tetanus toxin injected in the substantia nigra or striatum of freely moving rats. Spontaneous and evoked dopamine re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03047-0
更新日期：2002-09-20 00:00:00
abstract：:Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02585-x
更新日期：2003-06-27 00:00:00
abstract：:Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00720-3
更新日期：1998-09-21 00:00:00
abstract：:To evaluate a hypothesized role of the vagus in the circannual metabolic cycle of hibernators, measures of annual weight gain, weight loss and cycle period were taken for the ground squirrel, Citellus lateralis, maintained in constant environmental conditions before and after subdiaphragmatic vagotomy. The surgery did...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90996-0
更新日期：1986-01-29 00:00:00
abstract：:Two monkeys were trained to perform 3 kinds of spatial tasks (right-left DR, up-down DR, and conditional position discrimination with delay). In the conditional position task, the animal was required to respond to the right (left) choice key when the cue had been presented on the upper (lower) position. Single unit ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90924-0
更新日期：1976-03-19 00:00:00
