Abstract:
:The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR which could still be fast enough to elicit action potential wind-up. RR size was correlated with a slow synaptic potential (detected in CPP or APV solution) with which it shared similar voltage dependence. The NK1 antagonist SR 140333 depressed cumulative depolarization, RR and slow synaptic potentials. It appears that the RR (and the ability to express wind-up) was determined by summation of slow synaptic potentials partly mediated via activation of NK1 receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Baranauskas G,Nistri Adoi
10.1016/s0006-8993(96)00997-3subject
Has Abstractpub_date
1996-11-04 00:00:00pages
329-32issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(96)00997-3journal_volume
738pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::5-HT2 receptor binding sites were measured (by saturation binding of [3H]ketanserin) in brain tissue obtained at postmortem from 19 suicide victims with definite evidence of depression and 19 sex and age-matched control subjects. Five of the suicide victims were receiving antidepressant drugs prior to death; 13 suicid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91621-6
更新日期:1988-03-08 00:00:00
abstract::Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models highlight cortical spreading depression (CSD) as a potential candidate. These studies have focused on CSD-associa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03191-7
更新日期:2001-02-09 00:00:00
abstract::Changes in the activity and amount of the neurotransmitter synthesizing enzyme tyrosine hydroxylase (TH) were measured in dopaminergic (DA) neurons of the A10-mesolimbic system of the rat following electrolytic lesions of their axons. Unilateral hypothalamic lesions in close proximity to the cell bodies resulted, with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90594-2
更新日期:1978-06-23 00:00:00
abstract::The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment conti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91182-z
更新日期:1991-10-18 00:00:00
abstract::Electrophysiological techniques and the retrograde transport of horseradish peroxidase (HRP) were used to determine the efferent projections from the caudal mediobasal hypothalamus to the amygdala. In pentobarbital anesthetized rats, the activity of 1780 mediobasal hypothalamic neurons was examined for response to sti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90147-0
更新日期:1977-02-01 00:00:00
abstract::Injections with [3H]leucine in the ventral parabrachial nuclei and nucleus Kölliker-Fuse of the cat revealed strong projections to the nucleus raphe magnus (NRM) and adjacent tegmentum, while similar injections in the adjacent nucleus subcoeruleus produced diffuse projections to large parts of the tegmentum, but not s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90977-8
更新日期:1988-04-26 00:00:00
abstract::The effect of stimulating the dorsal raphe nucleus (DRN) on the activity of single relay neurons in the dorsal lateral geniculate nucleus (LGNd) was studied in rats anesthetized with urethane. The position of stimulating electrodes was confirmed on histological sections processed with NADPH-diaphorase histochemistry w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90002-4
更新日期:1989-06-05 00:00:00
abstract::The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90019-8
更新日期:1987-09-01 00:00:00
abstract::To examine the effect of development on rabbit brain insulin and insulin-like growth factor (IGF) receptor expression, we characterized and quantitated receptor mRNAs by Northern blot analysis and affinity-labeled ligand bound receptors by SDS-PAGE and autoradiography. At various stages of development ranging from 23 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91361-u
更新日期:1993-03-05 00:00:00
abstract::Mitochondrial electron transport chain (ETC) function is selectively reduced in multiple tissues, including brain, from patients with Parkinson's disease (PD) and Alzheimer's disease (AD). The ETC defects are specific to each illness, involve complex I in PD and complex IV in AD, are transferable with mitochondrial DN...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00429-0
更新日期:1997-08-15 00:00:00
abstract::Rats selectively bred for high or low levels of emotionality represent an important and powerful tool to investigate the role of genetic variables in the occurrence of different anxiety disorders. In the present study, albino rats were selectively bred for differences in defensive freezing behavior in response to cont...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.044
更新日期:2008-10-03 00:00:00
abstract::Upon a physiological and pharmacological challenge, the responsiveness of extracellular glutamate levels in the prefrontal cortex, ventral tegmental area and locus coeruleus were studied using microdialysis. A 10-min handling period was used as a mild stressful stimulus. In all three brain areas, handling induced an i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01538-3
更新日期:1999-07-03 00:00:00
abstract::We previously reported that abdominal surgery induces Fos expression in specific hypothalamic and medullary nuclei and also causes gastric stasis. The gastric ileus is reduced by systemic capsaicin and abolished by central injection of corticotropin-releasing factor (CRF) antagonist. We studied the influence of system...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01281-4
更新日期:1997-02-14 00:00:00
abstract::In primary neuron cultures obtained from ventral mesencephalon of mouse fetuses, approximately 10-30% of the neurons were dopaminergic, as demonstrated by a rapid glyoxylic acid histofluorescence procedure, and another 10-30% were GABAergic as demonstrated by autoradiography. Resting membrane potentials averaged -58 m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90024-7
更新日期:1988-04-01 00:00:00
abstract::In an attempt to determine the basis for apparently conflicting reports of the effects of noradrenaline (NA) on the neurohypophyseal system and its effects on the parvocellular periventricular region of the paraventricular nucleus (PVN), recordings were made from the neurons in the supraoptic nucleus (SON) and the per...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90511-1
更新日期:1986-03-26 00:00:00
abstract::The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.07.018
更新日期:2013-09-05 00:00:00
abstract::Compelling evidence from experimental animal disease models and early-phase clinical trials identifies the transplantation of neural progenitor/stem cells (NSCs) as a viable path towards the development of clinically applicable exogenous stem cell therapies. Building from current advances in the field of NSC biology a...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2019.146615
更新日期:2020-02-15 00:00:00
abstract::Stroke-prone spontaneously hypertensive rats (SHRSP) are a well-characterized, genetic model for stroke. We showed earlier that the structure and function of the tight junctions in SHRSP blood-brain barrier endothelial cells is disturbed prior to stroke. To investigate the molecular events leading to endothelial dysfu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02670-1
更新日期:2001-08-10 00:00:00
abstract::We have established a cell line (TB) from a cerebrospinal fluid (CSF) specimen of a patient with a primary leptomeningeal melanomatosis. TB cell line was immunoreactive with the antibodies for low molecular weight neurofilament protein, vimentin, neuron-specific enolase, chromogranin, synaptophysin and HMB-45 (an anti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01197-x
更新日期:1999-05-08 00:00:00
abstract::Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90481-1
更新日期:1987-11-03 00:00:00
abstract::Memory and perception are two tightly interrelated cognitive processes, but the neural level of their interaction remains a matter of debate. Proponents of a late interaction emphasize feedback memory effects on visual processing, whereas others suggest that feed forward processing is affected by memory. In the visual...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.05.087
更新日期:2009-08-18 00:00:00
abstract::Damage to the medial temporal lobe (MTL) and diencephalon results in impaired long-term memory, which relies on the binding of multiple, mostly contextual, features. Recent neuroimaging and patient studies have suggested that impairments may also be present in working memory after MTL or diencephalic damage. To examin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.066
更新日期:2007-10-03 00:00:00
abstract::The effects of toluene on synaptic transmission and neuronal morphology were investigated using guinea pig hippocampal slices. Population spikes (PS) were elicited in granule cell layer by stimulation of the perforant path and antidromic potentials (AP) were evoked in the same locii by stimulation of mossy fibers. Tol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91983-6
更新日期:1994-11-21 00:00:00
abstract::Fasting induced a reduction in neuronal nitric oxide synthase (nNOS) mRNA in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of rats. The effect of intracerebroventricular (i.c.v.) administration of leptin on the nNOS mRNA level in the PVN and SON of fasting rats was studied by in situ hybridization his...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02065-x
更新日期:1999-11-06 00:00:00
abstract::Prostaglandin E2 (PGE2) and proton are typical inflammatory mediators. They play a major role in pain processing and hypersensitivity through activating their cognate receptors expressed in terminals of nociceptive sensory neurons. However, it remains unclear whether there is an interaction between PGE2 receptors and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146442
更新日期:2019-12-01 00:00:00
abstract::The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.015
更新日期:2014-11-24 00:00:00
abstract::Intracellular assessments of the physiological actions of cannabinoid receptor agonists and antagonists on adult hippocampal CA1 pyramidal cells in the in vitro slice preparation were performed using current clamp and conventional sharp-electrode intracellular recording procedures. Several manipulations were performed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02110-7
更新日期:2000-04-28 00:00:00
abstract::Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90117-8
更新日期:1983-12-12 00:00:00
abstract::Afferent pathways innervating the urinary bladder consist of myelinated Adelta- and unmyelinated C-fibers, the neuronal cell bodies of which correspond to medium and small-sized cell populations of dorsal root ganglion (DRG) neurons, respectively. Since hyperpolarization-activated cyclic nucleotide-gated cation (HCN) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.052
更新日期:2006-11-13 00:00:00
abstract::During cerebral ischemia, dysregulated glutamate release activates N-methyl-d-aspartate (NMDA) receptors which promotes excitotoxicity and intracellular acidosis. Ischemia also induces cellular adenosine (ADO) release, which activates ADO receptors and reduces neuronal injury. The aim of this research was to determine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.115
更新日期:2006-04-12 00:00:00