Abstract:
:Experiments were done in cats to identify neurons in the paramedian reticular nucleus (PRN) sending collateral axons to the region of the intermediolateral nucleus (IML) at different levels of the thoracic cord by using lectin-conjugated horseradish peroxidase (HRP) and double-labeling fluorochrome histochemistry to retrogradely label PRN neurons. Injections of Fast blue (FB) into the spinal cord at the T2 level centered in the region of the IML were coupled with injections of Nuclear yellow (NY) into the ipsilateral cord at either the T4 or T7 levels centered in the region of the IML. Neurons in the PRN retrogradely labeled after diffusion of HRP into the region of the IML at the T2 level were observed throughout the rostrocaudal extent of the ventral PRN. In addition, a few labeled neurons were noted in the ventral portion of the dorsal PRN. About 40% of the neurons in the PRN which were labeled with FB after an injection at the T2 level were also labeled with NY injected into the cord in further caudal segments. These data suggest that the PRN may exert its influence on the cardiovascular system partly through collateral axonal branches to widely separated populations of sympathetic preganglionic neurons in different spinal segmental levels.
journal_name
Brain Resjournal_title
Brain researchauthors
Elisevich K,Caverson MM,Flumerfelt BA,Hrycyshyn AW,Ciriello Jdoi
10.1016/0006-8993(87)90377-5subject
Has Abstractpub_date
1987-04-07 00:00:00pages
227-32issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90377-5journal_volume
408pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Experiments were undertaken to compare effects of the NMDA and non-NMDA receptor antagonists, AP5 (40 microM) and NBQX (10 microM), on glutamate-induced firing in supraoptic oxytocin (OT) and vasopressin (VP) neurones in vitro. In putative OT neurones NBQX caused a significantly greater reduction in firing than AP5, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00728-2
更新日期:1997-08-29 00:00:00
abstract::In order to elucidate the mechanisms that PKCγ regulates neuropathic pain (NP), and detect proteins that are associated with the function of PKCγ in NP, we exploited a chronic constriction injury (CCI)-induced neuropathic pain rat (CCI-NP rat) model in which PKCγ knockdown in the spinal cord was successfully carried o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.12.046
更新日期:2012-02-27 00:00:00
abstract::Serotonin (5HT) is thought to reset the biological clock in the suprachiasmatic nuclei (SCN) in vitro through a postsynaptic 5HT-1a receptor. Thus we examined 5HT receptor gene expression in the SCN by in situ hybridization. On film autoradiograms, 5HT-1c receptor mRNA showed intense SCN hybridization, while 5HT-1b re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90789-p
更新日期:1993-04-09 00:00:00
abstract::Brain capillaries form a selective interface, the blood-brain barrier (BBB), between the neural parenchyma and the blood. The factors which regulate this interface are poorly understood. Both the iris and retina possess vascular beds that express some BBB characteristics; therefore, they provide attractive models to f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91323-k
更新日期:1993-12-03 00:00:00
abstract::Males show suppressed cell proliferation in the hippocampus in response to acute stress but no studies to date have examined cell proliferation in response to acute stress in females. In the current study, we examined the effects of acute exposure to a predator odor stressor [trimethyl thiazoline (TMT); the main compo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02542-3
更新日期:2003-06-13 00:00:00
abstract::Using cervical sympathectomized and immobilized rabbits, the relationship between the luminance intensity and the magnitude of the response in pupillo-constrictor units of the ciliary nerve was investigated. It was revealed that the intensity--response relationship of the units closely resembled that of retinal recept...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90787-8
更新日期:1980-11-10 00:00:00
abstract::A direct, although transient, projection from the sensorimotor cortex to the cerebellum has been described previously in the neonatal kitten. The present report demonstrates that this pathway can be induced to persist into juvenile stages of the cat by partially denervating the deep cerebellar nuclei. Most of the cere...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80021-x
更新日期:1986-11-01 00:00:00
abstract::The distribution of glucagon-like peptide-1-(7-36)amide like immunoreactivity (GLP-1-(7-36)NH2 IR) in rat brain was determined. Highest concentrations were found in the hypothalamus. A combination of gel chromatography and anion exchange chromatography showed that the majority of hypothalamic immunoreactivity exactly ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90628-8
更新日期:1989-11-20 00:00:00
abstract::In the central nervous system (CNS) insulin mediates a variety of effects including feeding, metabolism and cognition. The cognitive enhancing effects of insulin are proposed to be mediated through activation of insulin receptors in the hippocampus, an important integration center for learning and memory in the mammal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.005
更新日期:2009-11-03 00:00:00
abstract::The ganglion cells are the output neurons of the retina. There is, however, relatively little known about the neurotransmitters used by these cells. In the present study, ganglion cells identified with a ganglion cell-specific monoclonal antibody (AB5) are shown in separate double-label experiments to be gamma-aminobu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91498-9
更新日期:1988-01-26 00:00:00
abstract::The neurotoxic effects of amyloid-beta(1-42) and amyloid-beta(25-35) (A beta) on cholinergic and acetylcholinesterase-positive neurons were investigated in primary cultures derived from embryonic 18-day-old rat basal forebrain. After various time intervals, the cultures were treated with 1, 5, 10 or 20 microM A beta f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.021
更新日期:2004-02-13 00:00:00
abstract::Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glosso...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.04.024
更新日期:2004-07-16 00:00:00
abstract::Neurotensin-producing perikarya and fibers have been identified in the ventral tegmental area of the rat, and recent microinjection studies indicate that neurotensin may function in the ventral tegmental area to regulate body temperature. In this study, the hypothermic response produced by intraventral tegmental injec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90031-9
更新日期:1985-02-11 00:00:00
abstract::The effects of intracerebroventricular (i.c.v.) infusion of arginine vasopressin (AVP) on intracranial pressure (ICP), blood pressure (BP) and plasma AVP were investigated in conscious goats. The animals were implanted with ventricular (V) and cisternal (C) cannulae under halothane anaesthesia and allowed to recover p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90850-x
更新日期:1987-10-13 00:00:00
abstract::Synaptic plasma membrane preparations from brain tissue have endogenous Ca2+-dependent phospholipase A2 activity. Characterization of this activity revealed that it was maximally active at 10(-7)-10(-5) M Ca2+ and pH 7.0. The enzyme had a Km of 62.0 microM and a Vmax of 98.0 nmol/mg/h. Calmodulin and prostaglandin F2 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90944-2
更新日期:1984-01-09 00:00:00
abstract::The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.03.024
更新日期:2019-07-15 00:00:00
abstract::The outer plexiform layer (OPL) of the retina has been studied in the developing cat, from E (embryonic day) 30. Prior to E51 the layer could not be detected, the retina comprising two cell layers, an inner layer which becomes the ganglion cell layer of the adult, and an outer 'neuroblast' layer. The OPL was first det...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90126-2
更新日期:1982-11-01 00:00:00
abstract::Inhibition of nitric oxide (NO) synthesis has been found to produce learning deficits in spatial tasks. Recent studies also suggest a regulatory effect of endogenous NO on hippocampal serotonin (5-HT) release and have shown that NO-synthase (NOS) inhibitors increased extracellular levels of serotonin (5-HT) in the rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03987-2
更新日期:2003-02-14 00:00:00
abstract::The content and turnover of dopamine, norepinephrine and 5-hydroxytryptamine (serotonin), and the content of their respective major metabolites were evaluated in 19 discrete brain areas of rats exposed to conditioned emotional response (CER), and in control groups which received either equivalent yoked shock (shock on...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90647-3
更新日期:1982-05-20 00:00:00
abstract::We have recently reported the existence within chick embryo heart cell conditioned medium (HCM) of two distinct and independently assayable factors. One agent, ciliary neuronotrophic factor (CNTF), supports the in vitro survival of 8-day chick embryo ciliary ganglionic (CG) neurons. The other factor, polyornithine-att...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90105-0
更新日期:1981-02-09 00:00:00
abstract::Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90771-x
更新日期:1976-07-30 00:00:00
abstract::To assess the role of androgen-dependent brain vasopressinergic transmission in the modulation of social recognition, castrated male rats which are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini-device containing 10 micrograms vasopressin (AVP) whereas intact male rats...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90480-w
更新日期:1992-02-14 00:00:00
abstract::(1) Spontaneous barbiturate spindles were recorded from the primary and secondary somatosensory cortex. The recordings were concentrated to areas surrounding several reference loci. The recording sites producing the maximal response evoked by stimulation of an exposed nerve in a contralateral limb were used as referen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90984-7
更新日期:1976-01-09 00:00:00
abstract::Temporal changes in cholinergic functions following transient cerebral ischemia (10 min) were studied in the hippocampus of awake unrestrained gerbils using in vivo microdialysis. These data were compared with the results for temporal change in the area of each CA1 cell soma, measured with a microcomputer imaging devi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91765-5
更新日期:1994-03-07 00:00:00
abstract::The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00990-0
更新日期:1996-10-28 00:00:00
abstract::The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90800-o
更新日期:1992-03-06 00:00:00
abstract::Clozapine therapy has been associated with a high degree of urinary disturbances. The purpose of this study is to examine the effect of clozapine on urodynamic parameters and on the activity of the external urethral sphincter in anesthetized rats. Single cystometrograms (CMG) were performed on urethane-anesthetized fe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02352-6
更新日期:2001-05-18 00:00:00
abstract::Amyloid precursor protein (APP) is a ubiquitously expressed membrane spanning glycoprotein which is endoproteolytically processed to Abeta, a 39-43 amino acid peptide that is the main component of senile plaques in Alzheimer Disease (AD). APP is a member of a highly conserved gene family, including Amyloid Precursor-L...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00653-2
更新日期:1998-08-31 00:00:00
abstract::Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90336-0
更新日期:1994-07-25 00:00:00
abstract::Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and gamma-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acety...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91131-9
更新日期:1983-03-28 00:00:00