An evaluation of the use of intraventricularly administered [3H]5-hydroxytryptamine as a marker for endogenous brain 5-hydroxytryptamine.

abstract：:Climbing fiber responses (CFRs) evoked by white matter stimulation and parallel fiber responses (PFRs) elicited by the stimulation of the surface of the folium were compared using intracellular recording from the dendrites of Purkinje cells in the in vitro slice preparation of the guinea pig cerebellum. Intracellular ...

journal_title：Brain research

authors： Kimura H,Okamoto K,Sakai Y

更新日期：1985-12-02 00:00:00

abstract：:Rats exposed to stressors that cannot be controlled may develop a deficit in their ability to subsequently learn to control a new stressor. This phenomenon is known as 'learned helplessness' and is a well-accepted animal model of depression. Evidence is presented showing that rats having different directional biases o...

journal_title：Brain research

authors： Carlson JN,Glick SD

更新日期：1991-06-07 00:00:00

abstract：:Arg-vasopressin (AVP) containing neurons are one of the output paths from the suprachiasmatic nucleus (SCN), the center of the biological clock. AVP mRNA transcription is controlled by a negative feedback loop of clock genes. Circadian rhythm of melatonin release from the pineal gland is regulated by the SCN via the p...

journal_title：Brain research

authors： Isobe Y,Nishino H

更新日期：2004-07-09 00:00:00

abstract：:The purpose of this study was to identify the functional fields activated in relation to the self-paced proximal and distal arm movements. The regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) and 15O-labelled H2O (H2(15)O) in eight healthy subjects. All subjects performed the fo...

journal_title：Brain research

authors： Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Takahashi K,Yanagisawa T,Fukuda H

更新日期：1996-04-15 00:00:00

abstract：:Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific [3H]Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro. This increase occurs rapidly, by 20 min following exposure to stress, and resolves by 60 min. Increased benzodiazepine recepto...

journal_title：Brain research

authors： Miller LG,Thompson ML,Greenblatt DJ,Deutsch SI,Shader RI,Paul SM

更新日期：1987-06-30 00:00:00

abstract：:We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems). In the tail-pinch test, the antinociceptive effect of DSIP was...

journal_title：Brain research

authors： Nakamura A,Sugao T,Yamaue K,Kobatake M,Shiomi H

更新日期：1989-02-20 00:00:00

abstract：:Individual choroid plexuses of human fetal brain at different developmental stages were investigated by an indirect immunoperoxidase technique. The number and distribution of prealbumin-, albumin-, alpha-fetoprotein-, transferrin-, IgG-, IgA-, IgM- and alpha 1-antitrypsin-containing choroid plexus epithelial cells wer...

journal_title：Brain research

authors： Jacobsen M,Jacobsen GK,Clausen PP,Saunders NR,Møllgård K

更新日期：1982-02-01 00:00:00

abstract：:The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), a synthetic precursor of norepinephrine (NE), on the long-term potentiation (LTP) in the hippocampal mossy fiber-CA3 system was examined in urethane-anesthetized rats, the objective being to determine whether or not this drug acts as NE on the LTP. L-thr...

journal_title：Brain research

authors： Sakai N,Sasa M,Ishihara K,Komure O,Tanaka C,Takaori S

更新日期：1991-12-20 00:00:00

abstract：:The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Intrastriatal...

journal_title：Brain research

authors： Boegman RJ,Parent A

更新日期：1988-06-14 00:00:00

abstract：:The ability to detect and cope with unpredictable novel events is fundamental for adapting to a rapidly changing environment and ensuring the survival of the organism. Despite knowledge of gender differences in emotional processing, little is currently known about the impact of gender on neural processing of emotion-i...

journal_title：Brain research

authors： Yuan J,Xu S,Li C,Yang J,Li H,Yuan Y,Huang Y

更新日期：2012-02-09 00:00:00

abstract：:We examined the effect of gangliosides on Schwann cell cultures isolated from neonatal rat sciatic nerves. Addition of gangliosides (GM1, GM3, and ganglioside mixture) at concentrations between 0.25 and 2 mg/ml significantly diminished both the baseline rate of proliferation of the Schwann cells and their response to ...

journal_title：Brain research

authors： Sobue G,Taki T,Yasuda T,Mitsuma T

更新日期：1988-12-06 00:00:00

abstract：:Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These da...

journal_title：Brain research

authors： Zhang RX,Liu B,Lao L,Qiao JT,Ruda MA

更新日期：2005-03-21 00:00:00

abstract：:Mechanisms underlying hypoxia-induced neuronal adaptation have not been fully elucidated. In the present study we investigated glucose metabolism and the activities of glycolytic and TCA cycle enzymes in cerebro-cortical neurons exposed to hypoxia (3 days in 1% of O2) or normoxia (room air). Hypoxia led to increased a...

journal_title：Brain research

authors： Malthankar-Phatak GH,Patel AB,Xia Y,Hong S,Chowdhury GM,Behar KL,Orina IA,Lai JC

更新日期：2008-09-10 00:00:00

abstract：:Using mild heat shock of rat brain slices as a model for cellular insult, corticosteroid-mediated regulation of protein synthesis has been investigated. Following a single in vivo injection of rats with corticosterone or the Type II glucocorticoid receptor agonist, RU-28362, synthesis of a 28 kDa protein is elevated i...

journal_title：Brain research

authors： Barr CS,Dokas LA

更新日期：1999-11-13 00:00:00

abstract：:Transiently increased immunoreactivity of the calcium binding protein S-100beta was demonstrated in spinal ganglion nerve cells after sciatic nerve transection. Neuropeptide Y (NPY), normally not seen in these nerve cells, appeared concomitantly. The transiently elevated co-expression of S-100beta and NPY is proposed ...

journal_title：Brain research

authors： Huang YL,Ding M,Hansson HA

更新日期：1998-03-02 00:00:00

abstract：:Novel environments induce a conflicting emotional approach-withdrawal state that triggers stress-related reactions. Social support through the presence of a highly familiar conspecific buffers the individual against such challenges. Although aversive events seem to be predominantly processed by the right hemisphere, t...

journal_title：Brain research

authors： Pereira LC,Barros M

更新日期：2021-01-15 00:00:00

abstract：:Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...

journal_title：Brain research

authors： Jiao X,Paré WP,Tejani-Butt SM

更新日期：2006-02-16 00:00:00

abstract：:Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before i...

journal_title：Brain research

authors： Szerdahelyi P,Kása P

更新日期：1988-03-22 00:00:00

abstract：:Immunofluorescence on primary dissociated rat neuronal cultures (cortical, hippocampal, and cerebellar) and organotypic hippocampal cultures was used to investigate the pattern of distribution of cell-surface amyloid protein (APP). Antibodies directed against the extracellular (N-terminal) portion of APP or against th...

journal_title：Brain research

authors： Storey E,Beyreuther K,Masters CL

更新日期：1996-10-07 00:00:00

abstract：STUDY OBJECTIVE:To examine the differential effects of acute and chronic sleep fragmentation (SF) on spatial learning and memory, and hippocampal long-term potentiation (LTP) in pubertal mice. METHODS:Two studies were performed during which adolescent C57/Bl6 mice were subjected to acute-SF 24h a day × 3 days or chron...

journal_title：Brain research

authors： Wallace E,Kim DY,Kim KM,Chen S,Blair Braden B,Williams J,Jasso K,Garcia A,Rho JM,Bimonte-Nelson H,Maganti R

更新日期：2015-07-30 00:00:00

abstract：:The production and localization of cell-associated forms of beta-amyloid precursor protein (APP) of Alzheimer's disease was investigated in primary cultures of mouse glial cells. In both oligodendrocytes and astrocytes, immunofluorescence staining with an antibody against the carboxy terminus of APP revealed an intens...

journal_title：Brain research

authors： Mizuguchi M,Ikeda K,Kim SU

更新日期：1992-07-03 00:00:00

abstract：:We previously reported that aquaporin 4 (AQP4) played a critical role in formation of brain edema and the altered expression of dystroglycan (DG) could relate with AQP4 expression after traumatic brain injury (TBI). However the mechanisms of this process remain unclear. DG was showed could act as a scaffold involved i...

journal_title：Brain research

authors： Zhang G,Ma P,Wan S,Xu J,Yang M,Qiu G,Zhuo F,Xu S,Huo J,Ju Y,Liu H

更新日期：2019-10-15 00:00:00

abstract：:Effects of methamphetamine (MAP) on the extracellular neuropeptide Y (NPY) and noradrenaline (NA) levels were examined in the vicinity of the paraventricular nucleus (PVN) of freely moving rats by means of push-pull perfusion. The NA and NPY levels increased significantly in 30-60 min and reached the maximum level in ...

journal_title：Brain research

authors： Yoshihara T,Honma S,Mitome M,Honma K

更新日期：1996-01-22 00:00:00

abstract：:Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-...

journal_title：Brain research

authors： Arredondo C,González M,Andrés ME,Gysling K

更新日期：2016-12-01 00:00:00

abstract：:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...

journal_title：Brain research

authors： Lew R,Grigoriadis D,Wilson A,Boja JW,Simantov R,Kuhar MJ

更新日期：1991-01-25 00:00:00

abstract：:Recently, the gene encoding the cerebrovascular and neuritic plaque amyloid, a pathologic stigma of Alzheimer's disease (AD), has been molecularly cloned and mapped to human chromosome 21, band q21. Changes in the brains of individuals with trisomy 21 (Down syndrome, DS) over 35 years of age closely resemble AD neurop...

journal_title：Brain research

authors： Reeves RH,Robakis NK,Oster-Granite ML,Wisniewski HM,Coyle JT,Gearhart JD

更新日期：1987-09-01 00:00:00

abstract：:These experiments were conducted in order to better understand the role of catecholaminergic neurons in intracranial self-stimulation behaviour (ICSS) elicited from the lateral hypothalamus (LH). Two strains of mice which differ in their ICSS rate and their thresholds were studied. In a first time, we compared the cat...

journal_title：Brain research

authors： Garrigues AM,Cazala P

更新日期：1983-04-18 00:00:00

abstract：:The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory ami...

journal_title：Brain research

authors： Yang CS,Lin NN,Liu L,Tsai PJ,Kuo JS

更新日期：1995-11-06 00:00:00

abstract：:The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...

journal_title：Brain research

authors： Rasmussen K,Strecker RE,Jacobs BL

更新日期：1986-03-26 00:00:00

abstract：:The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...

journal_title：Brain research

authors： Gudehithlu KP,Reddy PL,Bhargava HN

更新日期：1994-03-14 00:00:00