Abstract：
:The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anesthetized cats with an intact central nervous system. In total, 54 neurons were recorded: 49 neurons with activity modulated by central respiratory rhythm (20 inspiratory, 17 postinspiratory and 12 expiratory) and 5 neurons with activity correlated to tracheal pressure. The recorded neurons were clustered in dorsolateral pontine tegmentum within the Kölliker-Fuse (KF) subnucleus of the parabrachial nuclei. Stable intracellular membrane potential was recorded in 11 of the 49 respiratory neurons (8 postinspiratory, 1 early inspiratory and 2 inspiratory). During continuous injection of chloride ions (n = 6), synaptic noise increased and IPSPs reversed, including a wave of IPSPs during stage-2 expiration in postinspiratory neurons. Further, relative input resistance varied through the respiratory cycle such that the least input resistance occurred during the neuron's (n = 5) quiescent period. No IPSPs nor EPSPs were evoked in pontine respiratory neurons by vagal stimulation. In conclusion, various types of respiratory neurons were recorded in the KF nucleus. Prominent excitatory and inhibitory postsynaptic activities were similar to those described for medullary neurons. These pontine respiratory neurons do not appear to receive a strong afferent input from the vagus. Rather, vagal afferent inputs seem to be directed towards non-respiratory neurons that are located more medially in the dorsal pons.
journal_name
Brain Resjournal_title
Brain researchauthors
Dick TE,Bellingham MC,Richter DWdoi
10.1016/0006-8993(94)91025-1subject
Has Abstractpub_date
1994-02-14 00:00:00pages
259-69issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91025-1journal_volume
636pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The amygdala is a bilateral temporal lobe brain region which plays an important role in emotional processing. Past studies on the amygdala have shown hemispheric differences in amygdalar processes and responses associated with specific pain and fear behaviors. Despite the functional differences in the amygdala, few st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.028
更新日期：2018-01-01 00:00:00
abstract：:The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91020-3
更新日期：1980-06-16 00:00:00
abstract：:In order to investigate protein function in rat primary cortical neuronal cultures, we modified an adenoviral vector expression system and assessed the strength and specificity of the cytomegalovirus (CMV), rous sarcoma virus (RSV), and rat and human synapsin 1 (SYN1) promoters to drive DsRed-X expression. We also inc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.089
更新日期：2006-08-02 00:00:00
abstract：:Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.12.035
更新日期：2016-02-15 00:00:00
abstract：:Previous studies found that injection of the GABA uptake inhibitor nipecotic acid into the nucleus tractus solitarius (NTS) increases arterial pressure. This effect of nipecotic acid was not antagonized by the selective GABAA receptor blocking agent bicuculline, suggesting that the action of nipecotic acid was mediate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91227-8
更新日期：1990-09-03 00:00:00
abstract：:Perfusion of hippocampal slices with normoxic medium containing no added sodium resulted in a rapid loss of the CA1 population spike, with only 35 +/- 10% (S.E.M.) (P < 0.001) recovery after a 15 min exposure. This injury was prevented by the non-competitive N-methyl-D-aspartate (NMDA) antagonist MK-801 (93 +/- 4% rec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91464-p
更新日期：1992-11-06 00:00:00
abstract：:In continuation of our quantitative studies on 15-day fetal rat brain development, evidence was obtained of ventricular mitoses whose spindles are perpendicular to the surface of the ventricle. In most locations the proportion (ratio) between cells with perpendicular mitoses and predominant cells with mitoses parallel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90094-0
更新日期：1987-01-01 00:00:00
abstract：:We previously reported that oral l-citrulline (l-Cit) administration antagonizes neuronal cell death in hippocampus following transient brain ischemia and that oral glutathione (GSH) administration prevents neuronal death through antioxidant activity. Here, we tested potential synergy of combined l-Cit and GSH adminis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.03.014
更新日期：2017-05-15 00:00:00
abstract：:The involvement of terminal sprouts in neurotransmitter release by in vivo botulinum type-A toxin poisoned motor endings was investigated 15 to 40 days after a single injection of the toxin onto the levator auris longus muscle of the mouse. Enhanced quantal acetylcholine release was induced by alpha-latrotoxin or La3+...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00475-2
更新日期：1998-06-29 00:00:00
abstract：:The localization of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) structures in the cochlea was examined in the rat using immunocytochemistry. Numerous CGRPI fibers entered the organ of Corti in the intraganglionic spiral bundle and formed a dense fiber patch at the base of the inner hair cells. M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90992-8
更新日期：1985-12-09 00:00:00
abstract：:It has been shown that glucagon like peptide-1 (GLP-1) acts on the central nervous system (CNS), in addition to its peripheral actions. Central administration of glucagon like peptide-1 (GLP-1) delays liquid gastric emptying via non-adrenergic, non-cholinergic neurons in rats. However, it remains unclear how central G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.090
更新日期：2006-09-21 00:00:00
abstract：:Antibody has been prepared to purified neurofilament protein extracted from calf brain. This antibody crossreacts with brain and nerve extracts from all mammals tested but fails to crossreact with frog, cod and chicken nerve extracts. Thus the serologic homology of these neurofilament proteins appears to be restricted...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)91074-5
更新日期：1977-10-07 00:00:00
abstract：:We investigated the effect of Cerebrospinal Fluid (CSF) from sporadic Amyotrophic Lateral Sclerosis patients (SALS-CSF) on motor neuron-like cells to delineate the pathomechanism of SALS. Exposure of NSC-34 cells to SALS-CSF caused lower viability, reduction in differentiation and enhanced lactate dehydrogenase activi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.041
更新日期：2009-03-31 00:00:00
abstract：:Immunohistochemistry was used to examine the co-occurrence of nicotinic acetylcholine receptor subunits with calcium-binding proteins in ganglion cells of the chick retina. The alpha3 subunit was rarely observed in ganglion cells containing calbindin, calretinin, or parvalbumin. On the other hand, the alpha8 subunit w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)81715-5
更新日期：1997-11-07 00:00:00
abstract：:The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90682-3
更新日期：1989-04-17 00:00:00
abstract：:Confocal microscopy and the Ca(2+)-sensitive fluorescent dye fluo-3 were used to study subcellular Ca2+ signals in embryonic, neonatal, and adult dorsal root ganglion (DRG) neurons in excised dorsal root ganglia. Optical images obtained from isolated whole embryonic and neonatal ganglia revealed a marked variability i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91444-3
更新日期：1994-01-28 00:00:00
abstract：:The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the effects of the acute administration of a sedative anticonvulsant dose of diazepam (2 mg/kg) on rat brain energy metabolism. This benzodiazepine was injected to rats chronically treated for two weeks either by caffeine (10 mg/kg/day) or ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90593-2
更新日期：1987-09-01 00:00:00
abstract：:Acute noradrenergic stimulation has previously been shown to stimulate brain (Na+, K+)-adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment;...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90258-4
更新日期：1981-06-01 00:00:00
abstract：:The aim of the present report is to investigate in detail morphometric changes of axon terminals of area 17 of adult cat induced by methylmercury intoxication. Six adult male cats (Felix catus), with 12 h day-light cycle and ad libitum water and food regimen, received a single dose of MeHgCl (6.4 mg/kg) dissolved in m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.036
更新日期：2008-12-09 00:00:00
abstract：:Preconditioning-induced cellular adaptation is a new therapeutic strategy for ischemic stroke. This research aims to examine the role of peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α (PGC-1α) and hypoxia induced factor-1α (HIF-1α) in hypoxic preconditioning-induced protection. In this study, rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.01.059
更新日期：2012-04-04 00:00:00
abstract：:The present study was undertaken to confirm the dorsolateral pontomesencephalic reticular formation (an area that includes the nucleus cuneiformis (NCF) and nucleus parabrachialis (NPB)) as a sensitive site for stimulation-produced antinociception and to investigate the possibility that there are cells in this region ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90171-6
更新日期：1989-04-03 00:00:00
abstract：:Both enkephalin and 5-hydroxytryptamine (5-HT) have been implicated in neural mechanisms underlying the central control of respiration. In view of the role of the nuclei tractus solitarii (NTS) in respiratory regulation, we carried out a study in artificially ventilated, chloralose-anaesthetized cats of the effects of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91515-x
更新日期：1985-02-18 00:00:00
abstract：:The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.103
更新日期：2009-11-03 00:00:00
abstract：:Nutrients in the intestine inhibit food intake via an action on the vagal afferent pathway. The aim of the present study was to use immunochemical detection of Fos protein-like immunoreactivity (FLI) in the brainstem to trace the neuronal pathways activated by intestinal nutrients. Perfusion of the intestine of awake ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91272-6
更新日期：1994-11-14 00:00:00
abstract：:Among 235 histologically identified cells of the ventral lateral geniculate nucleus (LGV) in the cat, 66 responded antidromically to electrical stimulation of the pretectum (PT) and/or superior colliculus (SC): 22 projected to PT, 22 to SC and 22 to both sites. The LGV cells were innervated by optic tract fibers corre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90993-x
更新日期：1985-12-09 00:00:00
abstract：:The effects of divalent and trivalent cations on the gamma-aminobutyric acid (GABA)-induced chloride current were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell configuration of the patch-clamp technique. Lanthanum (La3+) reversibly potentiated the GABA-induced current with a hal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91510-y
更新日期：1993-04-02 00:00:00
abstract：:In the rat, calbindin-like immunoreactivity was observed at both the light and electron microscopic levels within the chemoreceptor neurons of the vomeronasal organ (VNO) and both intragemmal cells and associated nerve fibers of the circumvallate taste buds. All VNO neurons were immunoreactive. Only a subset of intrag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90493-s
更新日期：1992-02-14 00:00:00
abstract：:Following cholinergic denervation of the hippocampus by medial septal lesions, and unusual neuronal reorganization occurs, in which peripheral sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. Previously, we have found that both hippocampal sympathetic ingrowth (HSI) and ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00070-7
更新日期：1995-04-10 00:00:00
abstract：:Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterizat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.006
更新日期：2012-12-07 00:00:00
abstract：:The distribution of avian pancreatic polypeptide (APP)-like immunoreactivity (APP-IR) in the chicken retina was investigated by means of immunohistochemistry. The observation from frozen sections showed that APP-IR is localized in the stratified amacrine cells of the first sublayer. Examination of whole-mounts reveale...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90022-2
更新日期：1984-09-17 00:00:00
