Pontine respiratory neurons in anesthetized cats.


:The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anesthetized cats with an intact central nervous system. In total, 54 neurons were recorded: 49 neurons with activity modulated by central respiratory rhythm (20 inspiratory, 17 postinspiratory and 12 expiratory) and 5 neurons with activity correlated to tracheal pressure. The recorded neurons were clustered in dorsolateral pontine tegmentum within the Kölliker-Fuse (KF) subnucleus of the parabrachial nuclei. Stable intracellular membrane potential was recorded in 11 of the 49 respiratory neurons (8 postinspiratory, 1 early inspiratory and 2 inspiratory). During continuous injection of chloride ions (n = 6), synaptic noise increased and IPSPs reversed, including a wave of IPSPs during stage-2 expiration in postinspiratory neurons. Further, relative input resistance varied through the respiratory cycle such that the least input resistance occurred during the neuron's (n = 5) quiescent period. No IPSPs nor EPSPs were evoked in pontine respiratory neurons by vagal stimulation. In conclusion, various types of respiratory neurons were recorded in the KF nucleus. Prominent excitatory and inhibitory postsynaptic activities were similar to those described for medullary neurons. These pontine respiratory neurons do not appear to receive a strong afferent input from the vagus. Rather, vagal afferent inputs seem to be directed towards non-respiratory neurons that are located more medially in the dorsal pons.


Brain Res


Brain research


Dick TE,Bellingham MC,Richter DW




Has Abstract


1994-02-14 00:00:00














  • Serum and fibroblast growth factor stimulate quiescent astrocytes to re-enter the cell cycle.

    abstract::An in vitro model was used to study the cytokinetics of astroglial cells derived from neonatal rat cerebellum. Confluent monolayers of astrocytes (85% astroglial as assessed by GFAP immunoreactivity) were subcultured at low cell density and after 2-3 days growth were rendered quiescent by shifting them to low serum me...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kniss DA,Burry RW

    更新日期:1988-01-26 00:00:00

  • The effect of electroacupuncture on proteomic changes in the motor cortex of 6-OHDA Parkinsonian rats.

    abstract::Electroacupuncture (EA) has been reported to alleviate motor deficits in Parkinson's disease (PD) patients, and PD animal models. However, the mechanisms by which EA improves motor function have not been investigated. We have employed a 6-hydroxydopamine (6-OHDA) unilateral injection induced PD model to investigate wh...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Li M,Li L,Wang K,Su W,Jia J,Wang X

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  • Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset.

    abstract::Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...

    journal_title:Brain research

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    authors: Pérez-Otaño I,Herrero MT,Oset C,De Ceballos ML,Luquin MR,Obeso JA,Del Río J

    更新日期:1991-12-13 00:00:00

  • A LANT6-like substance that is distinct from neuromedin N is present in pallidal and striatal neurons in monkeys.

    abstract::The basal ganglia of rhesus and squirrel monkeys were examined using immunohistochemical techniques with antibodies against the neurotensin-related hexapeptides Lys8-Asn9-Neurotensin(8-13) (LANT6) and Neuromedin N. A high percentage of neurons in both segments of globus pallidus and many large neurons of the striatum ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Reiner A

    更新日期:1987-09-29 00:00:00

  • A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.

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    journal_title:Brain research

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    authors: Kitanaka N,Kitanaka J,Hall FS,Uhl GR,Watabe K,Kubo H,Takahashi H,Tatsuta T,Morita Y,Takemura M

    更新日期:2012-01-06 00:00:00

  • Dorsal root ganglion nerve cells transiently express increased immunoreactivity of the calcium-binding protein S-100beta after sciatic nerve transection.

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    journal_title:Brain research

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    authors: Huang YL,Ding M,Hansson HA

    更新日期:1998-03-02 00:00:00

  • Age-related alterations of NMDA-receptor properties in the mouse forebrain: partial restoration by chronic phosphatidylserine treatment.

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    authors: Cohen SA,Müller WE

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    journal_title:Brain research

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    authors: McWilliams JR,Lynch G

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    authors: Xie T,Wang WP,Jia LJ,Mao ZF,Qu ZZ,Luan SQ,Kan MC

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  • Protection of oxidative preconditioning against apoptosis induced by H2O2 in PC12 cells: mechanisms via MMP, ROS, and Bcl-2.

    abstract::The present study is designed to investigate the effects of preconditioning with different doses of hydrogen peroxide (H2O2) on oxidative stress-induced apoptosis and the changes in mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) level, and expression of Bcl-2 during H2O2 preconditi...

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    authors: Tang XQ,Feng JQ,Chen J,Chen PX,Zhi JL,Cui Y,Guo RX,Yu HM

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    authors: Ying Z,Roy RR,Edgerton VR,Gómez-Pinilla F

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    authors: Hager AM,Dringenberg HC

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    authors: Narita K,Yokawa T,Nishihara M,Takahashi M

    更新日期:1993-02-19 00:00:00

  • Control of potassium currents and cyclic AMP levels by autoactive neuropeptides in Aplysia neurons.

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    journal_title:Brain research

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    authors: Hosford DA,Bonhaus DW,McNamara JO

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  • Retinotectal connections within the superficial layers of the cat's superior colliculus.

    abstract::Intracellular staining of neurons located in the superficial layers of the superior colliculus (SC) of the cat was carried out through an intracellular recording micropipette with which responses to stimulation of the optic chiasm (OX) and the optic tract (OT) ipsilateral to the explored SC were recorded. :A total of ...

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    authors: Lewis MH,Gluck JP,Beauchamp AJ,Keresztury MF,Mailman RB

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  • Immunocytochemical staining of neuropeptide Y (NPY) in the insular lobe of the monkey: a light microscopic study.

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  • Plasticity in the propagation of hippocampal stimulation-induced activity: a [14C]2-deoxyglucose mapping study.

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    journal_title:Brain research

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    authors: Baudry M,Arst D,Oliver M,Lynch G

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    journal_title:Brain research

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    journal_title:Brain research

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    authors: Wiley-Livingston CA,Ellisman MH

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  • Hyperprolactinemia: its electrophysiologic and pharmacologic effect on neurons of the ventromedial nucleus of the hypothalamus.

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    authors: Moss RL,Chan A,Dudley CA

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    authors: Tang YP,Wade J

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    pub_type: 杂志文章


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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Reyes BA,Van Bockstaele EJ

    更新日期:2006-10-30 00:00:00