Abstract：
:The involvement of terminal sprouts in neurotransmitter release by in vivo botulinum type-A toxin poisoned motor endings was investigated 15 to 40 days after a single injection of the toxin onto the levator auris longus muscle of the mouse. Enhanced quantal acetylcholine release was induced by alpha-latrotoxin or La3+ in conditions that prevent endocytosis, and an antibody directed against the lumenal domain of synaptotagmin II (Syt II) was used in the presence or absence of Triton X-100. We showed that, under resting conditions, the intravesicular domain of Syt II requires Triton X-100 to be labelled, whereas it becomes exposed to the outside of the axolemma of both the original terminal arborization and the newly formed sprouts during enhanced exocytosis. These data were taken to indicate that, when sprouting is prominent, the whole modified terminal arborization, including the original branches and the sprouts, possesses the machinery for Ca2+-independent exocytosis.
journal_name
Brain Resjournal_title
Brain researchauthors
Angaut-Petit D,Molgó J,Faille L,Juzans P,Takahashi Mdoi
10.1016/s0006-8993(98)00475-2subject
Has Abstractpub_date
1998-06-29 00:00:00pages
357-60issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00475-2journal_volume
797pub_type
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