Abstract：
:The distributions and inductions of Cu/Zn superoxide dismutase (SOD), neuronal and endothelial nitric oxide (NO) synthase (nNOS and eNOS), and nitrotyrosine (NT) were immunohistochemically examined in rabbit spinal cords after 5 and 15 min of transient ischemia. The neurons in the anterior horns (AH) were selectively lost 7 days after 15-min ischemia as compared with those of sham-operated controls. In the normal spinal cords, a number of neurons in the AHs were positive for the nNOS, and only slightly positive for the Cu/Zn SOD and the eNOS. Immunoreactivities for the proteins were induced at 8-24 h both after 5- and 15-min ischemia. In contrast, NT-like immunoreactivity was negative both in the normal and postischemic spinal cords. These results suggest that Cu/Zn SOD- and nNOS-, and eNOS-like immunoreactivities are induced, but that, even though an interaction of Cu/Zn SOD with NO could be present, NT was not detected in the motor neurons in the rabbit spinal cords after transient ischemia. Other factors could be required for NT formation found in degenerative motor neuron death in humans.
journal_name
Brain Resjournal_title
Brain researchauthors
Watanabe M,Sakurai M,Abe K,Aoki M,Sadahiro M,Tabayashi K,Okamoto K,Shoji M,Itoyama Ydoi
10.1016/0006-8993(96)00490-8subject
Has Abstractpub_date
1996-09-02 00:00:00pages
69-74issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00490-8journal_volume
732pub_type
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