Abstract：
:Adaptive behaviour requires that organisms continuously monitor the environment for potentially significant information and evaluate whether currently unattended stimuli afford a behavioural change. Here we used event-related functional magnetic resonance imaging in humans to assess the neural mechanisms underlying the evaluation of and rapid behavioural adjustments to salient stimuli occurring outside the current focus of (feature) attention. While subjects performed a task-switching paradigm in which they had to respond to either the colour or the shape of visual stimuli, occasionally deviant stimuli were presented that differed from the remaining stimuli with respect to the currently unattended feature. By systematically varying the frequency and the behavioural relevance of these perceptual deviations, we obtained a context-sensitive modulation of neural activity in a frontoparietal network including the posterior orbitofrontal cortex, the anterior cingulate cortex and the temporoparietal junction area, which may underlie a specific role in the adaptive guidance of behaviour in a changing environment. Together these brain regions may ensure that the relevance of a sudden environmental change is rapidly evaluated and implemented in appropriate action selection.
journal_name
Brain Resjournal_title
Brain researchauthors
Gruber O,Diekhof EK,Kirchenbauer L,Goschke Tdoi
10.1016/j.brainres.2010.06.056subject
Has Abstractpub_date
2010-09-10 00:00:00pages
212-21eissn
0006-8993issn
1872-6240pii
S0006-8993(10)01448-4journal_volume
1351pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The enzymes catalyzing the breakdown of TRH are soluble and dependent upon active sulfhydryl groups. One of these enzymes is a pyroglutamyl aminopeptidase (EC 3.4.11.8) (apparent molecular weight 60,000 daltons) with a specificity restricted to pyroglutamyl peptide bonds. The second enzyme is a prolyl endopeptidase (a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90309-2
更新日期：1982-06-24 00:00:00
abstract：:The effect of the sulfonamide derivative sulthiame (Ospolot) on voltage-operated sodium channels was investigated in acutely isolated neurons from the guinea pig hippocampus using the whole-cell patch-clamp technique. Sulthiame in a concentration of 10 microg/ml reduced the inactivating sodium currents without affecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02262-4
更新日期：2001-05-04 00:00:00
abstract：:Injection of inositol 1,4,5-trisphosphate (InsP3) into dark-adapted Limulus ventral photoreceptors produces a series of discrete bursts of membrane depolarization. Prior injection of aequorin, a luminescent calcium indicator, reveals that the bursts of depolarization are accompanied by individual bursts of intracellul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90860-2
更新日期：1987-10-13 00:00:00
abstract：:Field potentials (FP) recorded from the surface of toad's optic tectum (OT) to electrical stimulation of the contralateral optic nerve (ON) show initial positive deflections P*, followed by negative wave N and positive wave P; the former result from axonal inputs, the latter two resemble excitatory and inhibitory post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01260-o
更新日期：1995-01-09 00:00:00
abstract：:This study tested the hypothesis that the short-latency excitation of the phrenic motor output elicited by superior laryngeal nerve (SLN) stimulation requires non-NMDA receptor-mediated neurotransmission in the region of the dorsal respiratory group (DRG) of the adult cat. Injection of the non-NMDA receptor antagonist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00355-t
更新日期：1995-06-05 00:00:00
abstract：:Phospholipid extracts from 48 intracranial tumors were analyzed using 31P NMR. Phospholipids commonly identified in the tumor spectra included phosphatidylglycerol (PG), phosphatidic acid (PA), diphosphatidylglycerol (DPG), uncharacterized phospholipid (U), ethanolamine plasmalogen (EPLAS), phosphatidylethanolamine (P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91041-3
更新日期：1994-06-27 00:00:00
abstract：:Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigated the role of NO and of its newly recognized precursor, nitrite, in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.045
更新日期：2011-08-17 00:00:00
abstract：:The primary mechanism of action of bupropion, a smoking cessation drug, is commonly believed to involve the dopaminergic system although evidence exists that bupropion also has effects at nicotinic acetylcholine receptors (nAChRs). This study evaluated the disruptive effects of nicotine on response rates in the presen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.110
更新日期：2006-10-30 00:00:00
abstract：:We examined the effect of gangliosides on Schwann cell cultures isolated from neonatal rat sciatic nerves. Addition of gangliosides (GM1, GM3, and ganglioside mixture) at concentrations between 0.25 and 2 mg/ml significantly diminished both the baseline rate of proliferation of the Schwann cells and their response to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90442-8
更新日期：1988-12-06 00:00:00
abstract：:In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90018-4
更新日期：1983-06-01 00:00:00
abstract：:The distribution of bFGF in mouse and rat retinas was established using an antibody generated against a rat specific bFGF sequence. The patterns established with this antibody were distinctly different in comparison to the immunostaining patterns using antibodies prepared against similar regions of bovine and human bF...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91236-8
更新日期：1992-07-10 00:00:00
abstract：:In anaesthetized cats, medial gastrocnemius motor units (MUs) were stimulated with random sequences (mean rates between 6 and 12 pps) of electrical pulses delivered to their axons in small ventral root filaments. Muscle tension was recorded under isometric conditions, and spike trains of muscle spindle afferents were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91656-2
更新日期：1986-02-19 00:00:00
abstract：:The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02919-0
更新日期：2002-08-23 00:00:00
abstract：:Whole-cell voltage-clamp techniques were used to study the comparative effects of delta-9-tetrahydrocannabinol (THC) and its principal metabolite, 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC), on the voltage-gated sodium current in neuroblastoma cells. The parent compound markedly depressed the inward sodium cu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91239-w
更新日期：1991-09-27 00:00:00
abstract：:Individual vulnerability to the reinforcing effects of drugs appear to be a crucial factor in the development of addiction in humans. In the rat, individuals at risk for psychostimulant self-administration (SA) may be identified from their locomotor reactivity to a stress situation such as exposure to a novel environm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91452-7
更新日期：1991-12-13 00:00:00
abstract：:We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As prev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91085-1
更新日期：1986-10-22 00:00:00
abstract：:We investigated whether somatostain modulates the generation of long-term potentiation (LTP) in rat perforant path-dentate gyrus synapse in vivo. When somatostatin was injected intracerebroventricularly (i.c.v.) 20 min prior to the tetanus, the intensity of LTP increased dose dependently. Synaptic potential evoked by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00233-8
更新日期：1996-06-03 00:00:00
abstract：:The magnetoencephalographic signal was collected in a visually guided response-finger selection GO/NOGO task. The minimum norm distributed source analysis identified the sources in bilateral superior parietal lobules (SPL), with stronger activity for contralateral finger movement. Our results suggest that the human SP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02088-1
更新日期：2001-04-06 00:00:00
abstract：:It is known that transmitter release depends upon the entry of calcium ions into the synaptic terminal. Mitochondria have been suggested to play a key role on the regulation of intracellular Ca2+ concentration, thereby influencing transmitter liberation and synaptic transmission. Here we report the stimulatory effect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90618-6
更新日期：1980-01-13 00:00:00
abstract：:The nature of the delayed blood-brain barrier (BBB) opening that occurs in rats subjected to forebrain ischemia by the technique of two-vessel (carotid) occlusion plus hypovolemic hypotension (2VO ischemia) was probed by examining the simultaneous, trans-barrier movement of two hydrophilic, normally poorly permeative ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00323-5
更新日期：1997-06-27 00:00:00
abstract：:In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the res...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91453-3
更新日期：1987-05-26 00:00:00
abstract：:Male laboratory rats were raised in two colonies, each of 27 rats, and then given intraventricular injections of the norepinephrine neurotoxin 6-hydroxydopamine (6-OHDA) or the serotonin neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) or saline. They were then returned to their enclosure and behavior during the next 50 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90688-0
更新日期：1976-02-13 00:00:00
abstract：:To determine whether the paraventricular nucleus (PVN) contributes to the development of hypertension in spontaneously hypertensive rats (SHR), we compared cardiovascular responses to ganglionic blockade with hexamethonium or vasopressin antagonism with dPVAVP in sham-operated or PVN lesioned SHR and Wistar-Kyoto rats...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90040-3
更新日期：1991-03-15 00:00:00
abstract：:We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.064
更新日期：2006-02-16 00:00:00
abstract：:The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.04.045
更新日期：2010-06-25 00:00:00
abstract：:Our previous study [32] indicated that blockade of kappa-opioid receptors with nor-binaltorphimine (nor-BNI) in the medial preoptic area (MPOA) produced two different LH responses during midpregnancy in the rat: an increase in basal pulsatile LH secretion, followed in many cases by a larger and/or sustained increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00874-p
更新日期：1995-11-06 00:00:00
abstract：:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strength...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91311-2
更新日期：1992-10-16 00:00:00
abstract：:Ionizing radiations induce oxidative stress on target tissues, mainly through the generation of reactive oxygen species (ROS). However, there are few data available on the behavioral effects of moderate doses of ionizing radiation. The aim of the present work was to evaluate the performance of adult rats irradiated at...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.053
更新日期：2010-02-02 00:00:00
abstract：:We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also supp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91498-8
更新日期：1986-11-29 00:00:00
abstract：:Putative serotonergic dorsal raphe (DRN) neurons display a dramatic state-related change in behaviour, discharging regularly at a high rate during waking and at progressively slower rates during slow-wave sleep (SWS) and ceasing firing during paradoxical sleep (PS). Using the antidromic latency technique and extracell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02210-7
更新日期：2001-04-20 00:00:00
