Ascending dopaminergic projections from the dorsal raphe nucleus in the rat.

abstract：:Previous research has shown that hippocampal and neocortical activation accompanies the postural changes occurring during self-grooming in rats but is absent or reduced during the stereotyped components of grooming, including head-washing and licking or biting. Since electrocortical activation is dependent on ascendin...

journal_title：Brain research

authors： Robertson BJ,Boon F,Cain DP,Vanderwolf CH

更新日期：1999-08-14 00:00:00

abstract：:A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneuro...

journal_title：Brain research

authors： Knirsch U,Sturm S,Reuter A,Bachus R,Gosztonyi G,Voelkel H,Ludolph AC

更新日期：2001-01-19 00:00:00

abstract：:Neurotensin (NT) is an endogenous brain tridecapeptide for which high affinity binding sites exist in the central nervous system. We have investigated the effects of NT incubation with rat neostriatal slices on calcium/calmodulin (Ca/CaM)-dependent protein phosphorylation. Slices were incubated with NT (5 or 50 nM) fo...

journal_title：Brain research

authors： Kasckow J,Cain ST,Nemeroff CB

更新日期：1991-04-05 00:00:00

abstract：:The neurotoxic effects produced by ibotenic acid (IA) induced chemical lesions of the central nervous system (CNS) cholinergic system were examined on the opioid peptidergic system in adult rats. Forebrain cholinergic systems were bilaterally lesioned by the infusion of IA (1 or 5 micrograms/site) into the nucleus bas...

journal_title：Brain research

authors： Rattan AK,Tejwani GA

更新日期：1992-02-07 00:00:00

abstract：:Studies were conducted to assess whether stimulation of dopamine receptors located in the globus pallidus might play a role in mediating the enhanced pallidal activity seen after systemic administration of dopamine agonists or D-amphetamine. Dopamine, applied iontophoretically, had modest effects on the activity of pa...

journal_title：Brain research

authors： Bergstrom DA,Walters JR

更新日期：1984-09-17 00:00:00

abstract：:The effects of postnatal thyroidectomy (on day 8 after birth) and 131I treatment (on day 10) on the development of the vomeronasal organ (VO) has been studied In the rat. Thyroidectomized rats showed decrements in the overall VO volume, volume of the neurosensorial epithelium, neuronal population and nuclear size of n...

journal_title：Brain research

authors： Segovia S,Del Cerro MC,Guillamon A

更新日期：1982-10-01 00:00:00

abstract：:The double-labeling, fluorescent dye technique was used in order to demonstrate the extent to which the central processes of renal afferent neurons directly project to the brainstem. One injection of a fluorescent dye was placed in the cortex of the left kidney of male rats, and a second injection of a different dye w...

journal_title：Brain research

authors： Wyss JM,Donovan MK

更新日期：1984-04-23 00:00:00

abstract：:Dendritic architecture and distribution of dendritic protrusions were studied on Golgi-impregnated neurons in the medial preoptic area (MPOA) of infant rats (7 and 20 days old), of animals at puberty (34 days old) and of postpubertal rats (90 days old) using computerized image analysis. The protrusions showed a peak d...

journal_title：Brain research

authors： Geröcs K,Réthelyi M,Halász B

更新日期：1986-04-01 00:00:00

abstract：:Sensory fibers trapped in nerve-end neuromas become abnormally excitable, and produce an ectopic discharge which is believed to contribute to paresthesias and pain associated with chronic nerve injury in man. Here we report that stimulation of injured nerves can alter this discharge, directly by antidromic invasion of...

journal_title：Brain research

authors： Lisney SJ,Devor M

更新日期：1987-07-07 00:00:00

abstract：:The effect of L-AP4, a group III mGluR agonist, on sensory synaptic transmission in the lamprey spinal cord has been analyzed. Paired recordings were made between cutaneous mechanosensory neurons (dorsal cells) and postsynaptic spinobulbar giant interneurons. L-AP4 reduced the monosynaptic dorsal cell-evoked EPSP, but...

journal_title：Brain research

authors： Krieger P,El Manira A

更新日期：2002-05-24 00:00:00

abstract：:The present study has examined the involvement of sensory neurotransmitters in activating neurones in the trigeminal nucleus caudalis following stimulation of the trigeminovascular system in anaesthetised guinea-pigs. Electrical stimulation of the right trigeminal ganglion produced a unilateral expression of Fos-like ...

journal_title：Brain research

authors： Clayton JS,Gaskin PJ,Beattie DT

更新日期：1997-11-14 00:00:00

abstract：:By using immunocytochemistry we tested whether neurotransmitters, and enzymes specific to neurotransmitters synthesis are rhythmically expressed in the suprachiasmatic nuclei of the hypothalamus of Ruin lizards Podarcis sicula either kept in light-dark cycles or constant darkness. Within the suprachiasmatic nuclei, pr...

journal_title：Brain research

authors： Magnone MC,Bertolucci C,Piazza F,Foà A

更新日期：2003-05-23 00:00:00

abstract：:The primary olfactory cortex of mouse embryos varying in age from the 13th to the 15th day of gestation is investigated with the aid of several techniques: Nissl and Golgi preparations, autoradiography and electron microscopy. It is observed that the earliest cells to complete their migrations are diffusely scattered ...

journal_title：Brain research

authors： Derer P,Caviness VS Jr,Sidman RL

更新日期：1977-03-04 00:00:00

abstract：:In the inferior colliculus of the mouse, 4 cell types project across the collicular commissure: small to medium sized spiny cells, small to medium sized spineless cells, medium sized sparsely spinous neurons and large cells. The axons of large cells give rise to a great number of ipsi- and contralateral collaterals te...

journal_title：Brain research

authors： González Hernández TH,Meyer G,Ferres-Torres R

更新日期：1986-03-19 00:00:00

abstract：:It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relat...

journal_title：Brain research

authors： Maccari S,Piazza PV,Deminière JM,Angelucci L,Simon H,Le Moal M

更新日期：1991-05-10 00:00:00

abstract：PURPOSE:To determine whether antisense oligonucleotides (AODNs) targeted against CRX, a photoreceptor-specific trans-acting factor, suppress CRX expression and interphotoreceptor retinoid binding protein (IRBP) promoter activity. METHODS:Cultures of human retinoblastoma cells were transfected with chloramphenicol acet...

journal_title：Brain research

authors： Boatright JH,Borst DE,Stodulkova E,Nickerson JM

更新日期：2001-10-19 00:00:00

abstract：:The present study has shown that after intravenous injection of [125I]NGF the time-course of appearance of radioactivity in all organs studied with the exception of sympathetic and sensory ganglia, roughly paralleled that of the blood. The highest levels were reached immediately after injection, after which the radioa...

journal_title：Brain research

authors： Stoeckel K,Guroff G,Schwab M,Thoenen H

更新日期：1976-06-11 00:00:00

abstract：:We immunocytochemically examined the effect of chronic salt loading on the content of calretinin, a calcium-binding protein, in both the supraoptic nucleus and the magnocellular parts of the hypothalamic paraventricular nucleus. In control rats that were given water for drinking, the supraoptic nucleus contained a clu...

journal_title：Brain research

authors： Arai R,Jacobowitz DM,Nagatsu I

更新日期：1995-03-06 00:00:00

abstract：:Picrotoxin-induced epileptiform activity was examined in neocortical slices prepared from 8- to 15-day-old rats. This activity consisted of spontaneous bursts of 3-5 discharges that resembled interictal spikes and were interspersed with ictal-like paroxysms lasting 10-30 s. Measurements of extracellular potassium ([K+...

journal_title：Brain research

authors： Hablitz JJ,Heinemann U

更新日期：1987-12-01 00:00:00

abstract：:The roles of endogenous serotonin (5-HT) and 5-HT receptor subtypes in regulation of acetylcholine (ACh) release in frontal cortex of conscious rats were examined using a microdialysis technique. Systemic administration (1 and 3 mg/kg, i.p.) of the 5-HT-releasing agent p-chloroamphetamine (PCA) elevated ACh output in ...

journal_title：Brain research

authors： Yamaguchi T,Suzuki M,Yamamoto M

更新日期：1997-10-24 00:00:00

abstract：:The nature of the delayed blood-brain barrier (BBB) opening that occurs in rats subjected to forebrain ischemia by the technique of two-vessel (carotid) occlusion plus hypovolemic hypotension (2VO ischemia) was probed by examining the simultaneous, trans-barrier movement of two hydrophilic, normally poorly permeative ...

journal_title：Brain research

authors： Preston E,Foster DO

更新日期：1997-06-27 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study analyzed whether administration of sulindac, a non-steroidal anti-inflammatory drug (NSAID) would prevent, attenuate or repair ischemia induced brain injury and reverse functional impairment in a focal ischemia model of stroke. METHODS:Male Sprague-Dawley rats (weight 250-300 g...

journal_title：Brain research

authors： Modi JP,Gharibani PM,Ma Z,Tao R,Menzie J,Prentice H,Wu JY

更新日期：2014-08-12 00:00:00

abstract：:Facial allodynia is a migraine symptom that is generally considered to represent a pivotal point in migraine progression. Treatment before development of facial allodynia tends to be more successful than treatment afterwards. As such, understanding the underlying mechanisms of facial allodynia may lead to a better und...

journal_title：Brain research

authors： Wieseler J,Ellis A,McFadden A,Stone K,Brown K,Cady S,Bastos LF,Sprunger D,Rezvani N,Johnson K,Rice KC,Maier SF,Watkins LR

更新日期：2017-06-01 00:00:00

abstract：:The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...

journal_title：Brain research

authors： Cintron AF,Dalal NV,Dooyema J,Betarbet R,Walker LC

更新日期：2015-10-05 00:00:00

abstract：:The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by v...

journal_title：Brain research

authors： Clark RB,Gration KA,Usherwood PN

更新日期：1980-06-16 00:00:00

abstract：:Increasing adult neurogenesis in the hippocampal formation (HF) has been proposed as a potential foundation for neuronal repair in Alzheimer's disease (AD), but the evidence remains controversial. We used P8 strain of senescence-accelerated mice (SAMP8) as a model of AD to investigate changes in adult neurogenesis. We...

journal_title：Brain research

authors： Gang B,Yue C,Han N,Xue H,Li B,Sun L,Li X,Zhao Q

更新日期：2011-05-10 00:00:00

abstract：:Heme oxygenase-carbon monoxide-cGMP (HO-CO-cGMP) pathway has been reported to be involved in peripheral and spinal modulation of inflammatory pain. However, the involvement of this pathway in the modulation of acute painful stimulus in the absence of inflammation remains unknown. Thus, we evaluated the involvement of ...

journal_title：Brain research

authors： Carvalho PG,Branco LG,Panissi CR

更新日期：2011-04-18 00:00:00

abstract：:The cat substantia nigra (SN) pars reticulata (SNR) has been observed electron microscopically after ibotenic acid injections into the caudate nucleus (Cd) and horseradish peroxidase injections into the nucleus tegmenti pedunculopontinus pars compacta (TPC). As a result, degenerating striatal terminals were found to m...

journal_title：Brain research

authors： Tokuno H,Moriizumi T,Kudo M,Kitao Y,Nakamura Y

更新日期：1989-04-17 00:00:00

abstract：:Unilateral olfactory nerve section was performed in the mouse. Three biochemical markers of the olfactory chemoreceptor neurons: carnosine, carnosine synthetase activity and the olfactory marker protein, were measured in the olfactory bulb and epithelium. Parallel observations were made by light microscopy as well as ...

journal_title：Brain research

authors： Harding J,Graziadei PP,Monti Graziadei GA,Margolis FL

更新日期：1977-08-19 00:00:00

abstract：:The neuroactive steroid 5 beta-pregnan-3 alpha-ol-20-one (5 beta 3 alpha) modulates GABAA receptor function by potentiating postsynaptic GABA currents. While much is now known about the postsynaptic action of neurosteroids, far less is known about how they affect neurotransmission. We have investigated the synaptic ac...

journal_title：Brain research

authors： Reith CA,Sillar KT

更新日期：1997-10-03 00:00:00