Abstract：
:The primary olfactory cortex of mouse embryos varying in age from the 13th to the 15th day of gestation is investigated with the aid of several techniques: Nissl and Golgi preparations, autoradiography and electron microscopy. It is observed that the earliest cells to complete their migrations are diffusely scattered at all levels of the emerging cortical plate. The dendrites of these cells are predominantly tangentially aligned. Subsequently these early formed cells are subdivided into two groups. One group remains superficial in close relation to the lateral olfactory tract while the second is displaced to the deepest level of the cortex. The dendrites of many cells which remain at superficial cortical levels become realigned in a radially upward direction. "Maculae adherens diminutae" are abundant at points of apposition of membranes of cells of all classes at superficial cortical levels. It is suggested that these serve to stabilize cell position and that the upward dendritic realignment is an expression of radially directed stresses. Synapses appear relatively late and probably play no role as determinants of cell position.
journal_name
Brain Resjournal_title
Brain researchauthors
Derer P,Caviness VS Jr,Sidman RLdoi
10.1016/0006-8993(77)90641-2subject
Has Abstractpub_date
1977-03-04 00:00:00pages
27-40issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(77)90641-2journal_volume
123pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Our previous studies have indicated that oxygen radicals, produced during reoxygenation following short-term arterial hypoxia, lead to sustained suppression of cerebral arteriolar responses to N-methyl-D-aspartate (NMDA). However, whether arteriolar dilator responses to NMDA are reduced during arterial hypoxia has nev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01196-7
更新日期：1998-01-12 00:00:00
abstract：:Patches of transnueronal degeneration were produced in the lateral geniculate nucleus (LGN) by retinal laser burns and a tarsorrhaphy was performed in the contralateral eye of Macaca mulatta during infancy. The adverse effect of unilateral visual deprivation on geniculate cell growth was absent in those portions of de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90772-1
更新日期：1976-07-30 00:00:00
abstract：:A study of brains of 16 dogs from one to 19 years of age showed a structure- and cell-type- specific pattern of tau protein phosphorylation at mAb Tau-1 site and the absence of phosphorylation at the mAb AT8 site. Strong immunolabeling with mAb Tau-1 of the mossy fibers and perikarya of neurons in sectors CA3 and CA4 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00542-3
更新日期：1998-08-17 00:00:00
abstract：:The immunohistochemical localization of an endogenous lectin R1 isolated from the rat cerebellum was studied during its postnatal development. The lectin is present in the cerebellum from birth to adulthood, essentially in lysosomes, multivesicular bodies, and parts of the endoplasmic reticulum, principally of large a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90148-8
更新日期：1985-01-01 00:00:00
abstract：:The effect of single administrations of MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) or PCP (phencyclidine) on the induction of audiogenic seizure susceptibility by noise in immature rats was examined. Treatments with these non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists resul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91237-u
更新日期：1991-09-27 00:00:00
abstract：:Studies have demonstrated defects of DA and 5HT neurotransmission in dietary fat induced obese animals. In the present study, we used a perfusion system to assay the release of DA and 5HT from striatal slices preloaded with [(3)H]-DA or [(3)H]-5HT. The release of both DA and 5HT from striatal slices of rats fed a high...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.06.036
更新日期：2010-08-19 00:00:00
abstract：:In previous studies we have tested the hypothesis that the termination of the period of sexual behavior in female guinea pigs results from the loss of progestin receptors from hypothalamic cell nuclei. We have shown that hormonal manipulations that delay heat termination also delay loss of hypothalamic nuclear progest...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90320-3
更新日期：1986-05-14 00:00:00
abstract：:In the companion study (Dev. Brain Res., 34 (1987) 223-233), we showed that a monocular injection of antibodies against ox large retinal ganglion cells produces a 53% (low concentration) to 82% (high concentration) loss of Y-cells in lateral geniculate nucleus (LGN) layers A and A1 that receive inputs from the antibod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90212-4
更新日期：1987-08-01 00:00:00
abstract：:The genomic response following brain ischemia is very complex and involves activation of both protective and detrimental signaling pathways. Immediate early genes (IEGs) represent the first wave of gene expression following ischemia and are induced in extensive regions of the ischemic brain including cerebral cortex a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.005
更新日期：2007-06-02 00:00:00
abstract：:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91444-6
更新日期：1991-12-13 00:00:00
abstract：:The present study evaluated the central effects of beta-funaltrexamine (B-FNA), a non-equilibrium antagonist of mu-opioid receptors and a reversible agonist of kappa-opioid receptors upon food intake in rats under freely-feeding, deprivation and glucoprivic conditions. B-FNA elicited distinct short-term and long-term ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91828-5
更新日期：1990-12-03 00:00:00
abstract：:Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.050
更新日期：2004-04-09 00:00:00
abstract：:The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03014-2
更新日期：2003-08-29 00:00:00
abstract：:Alterations in local cerebral glucose utilization (LCGU) induced by electrical stimulation of the sensory relay nucleus (VPL) or parafascicular nucleus (Pf) of the thalamus in conscious rats were measured by the [14C]2-deoxyglucose method, the objective being to assess the mechanism of analgesia induced by electrical ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90357-x
更新日期：1987-04-07 00:00:00
abstract：:The 2,3-benzodiazepine derivative GYKI 52466 has been well characterized as a negative modulator of AMPA-type glutamate receptors. The present study re-examined the effects of GYKI 52466 on AMPA receptor-mediated currents in patches excised from pyramidal neurons in the hippocampal CA1 field and found that this drug h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03323-0
更新日期：2001-02-23 00:00:00
abstract：:The purpose of this study was to determine the ultrastructure of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different stages of disease. Electron microscope examination of brainstem, cervical and lumbar spinal cords was performed in ALS mice at early and late s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.044
更新日期：2007-07-09 00:00:00
abstract：:Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.042
更新日期：2009-12-11 00:00:00
abstract：:In a recent study in the tiger salamander, Ambystoma tigrinum, were demonstrated topographic patterns of responsivity across the olfactory epithelium which were characteristic for each odorant. The present study was initiated to investigate whether these patterns remain constant when odorant concentration is varied. O...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90562-6
更新日期：1984-04-16 00:00:00
abstract：:Saccadic adaptation maintains saccade accuracy and has been studied with targeting saccades, i.e. saccades that bring the gaze to a target, with the classical intra-saccadic step procedure in which the target systematically jumps to a new position during saccade execution. Post-saccadic visual feedback about the error...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.029
更新日期：2011-09-30 00:00:00
abstract：:Immunocytochemical and morphometric analyses were combined to demonstrate the presence of neuron subpopulations in the rat vestibular ganglion. Monoclonal antibodies reacting with neurofilament proteins (NF), calbindin-D 28K (CaBP) and calretinin (CaR) were used. Three subpopulations were identified: (1) CaBP- and CaR...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90334-6
更新日期：1992-06-05 00:00:00
abstract：:The effects of glucose injection into the hepatic portal vein on neural activity of the lateral hypothalamic area (LHA) were studied in rats. A majority of identified glucose-sensitive neurons in the LHA were inhibited by portal injection of glucose. This was found to be mediated through the alpha-noradrenergic pathwa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91332-x
更新日期：1983-04-11 00:00:00
abstract：:Neuromuscular patterns associated with the development of hindlimb stepping behaviors were studied from birth to postnatal day 60 in normal kittens. Hindlimb muscles were chronically implanted with EMG electrodes at birth to characterize interlimb coordination and intralimb synergies during development of overground a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90084-3
更新日期：1988-01-01 00:00:00
abstract：:Data reported up to now on neuron-glia relationships, show that neuron cell bodies and glial cells are separated by a narrow intercellular cleft which is considered as the microenvironment of the nervous system, and where neuron-glia exchange occurs. We present here evidence that neuron perikarya and ensheathing glial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91394-0
更新日期：1985-02-04 00:00:00
abstract：:The involvement of endogenous serotonergic pathways in the mediation of antinociception has been indicated by electrophysiological, pharmacological and behavioral experiments. However, manipulation of the indole pathway, either by lesioning of raphe nuclei or drug intervention, often produces disparate results. In par...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90883-3
更新日期：1987-11-24 00:00:00
abstract：:High-intensity stimulation of the supraorbital region elicits, together with a blink reflex, a reflex inhibition of the jaw-closing muscles in normal man. The response differs from the well known inhibition obtained by intra- and perioral stimulation in two main features. Firstly, it consists of a single late silent p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90366-5
更新日期：1986-04-23 00:00:00
abstract：:The immunocytological study of LH-RH producing neurons was carried out on 3 newborns and 14 fetuses (from 10 to 36 weeks of age). Perikarya and fibers which were immunoreactive to anti-LH-RH IS were revealed by IF or IE in all the hypothalamus beginning with the 13th week. Important variations in neurons staining may ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90992-1
更新日期：1977-06-10 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.063
更新日期：2004-03-19 00:00:00
abstract：:In a rat model of peripheral inflammation and hyperalgesia, dynorphin A(1-8)-like immunoreactive (DYN-LIr) spinal neurons were examined for contacts from calcitonin gene-related peptide-like immunoreactive (CGRP-LIr) varicosities using a double-label PAP method. Ipsilateral to the inflammation, CGRP-LIr varicosities c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90213-2
更新日期：1988-12-13 00:00:00
abstract：:Ethanol and nerve growth factor (NGF) affect the survival of cholinergic neurons in the rat medial septum. To investigate whether calcium (Ca2+) homeostasis in these neurons is affected by ethanol or NGF treatment, changes in intracellular free Ca2+ concentration ([Ca2+]i) were studied in embryonic (E21) cultured medi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00955-3
更新日期：1995-12-01 00:00:00
abstract：:As a model of chronic inflammatory pain, Freund's adjuvant-induced polyarthritis has been shown to be associated with marked alterations in the activity of opioid- and calcitonin gene-related peptide (CGRP)-containing neurons in the dorsal horn of the spinal cord in rats. Possible changes in the interactions between t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00350-3
更新日期：1998-06-15 00:00:00
