Abstract:
:The immunocytological study of LH-RH producing neurons was carried out on 3 newborns and 14 fetuses (from 10 to 36 weeks of age). Perikarya and fibers which were immunoreactive to anti-LH-RH IS were revealed by IF or IE in all the hypothalamus beginning with the 13th week. Important variations in neurons staining may translate "physiological" differences in their LH-RH charge but can be also the result of the diverse technical conditions. In three 16-week-old female fetuses, the large number of neurons (more than 150 per hypothalamus) permitted a good topographical and morphological study of them. They are scattered in vast areas of the anterior hypothalamus (lamina terminalis (LT) and septum), mediobasal and premammillary hypothalamus. The fibers which are particularly immunoreactive in semi-thin sections form a large hypothalamo-infundibular contingent in the posterior lip of the ME where they give rise to collaterals that terminate in contact with the capillaries of the mantelplexus, this taking place both before and after the apparition of the intra-eminential loops at the 16th week. Numerous in the LT, they terminate around the deep capillaries of the vascular organ or in contact with the ependymal epithelium. Some extra hypophyseal fibers go towards the epithalamus and the mesencephalon. To conclude, very early, in the human fetus the peptidergic LH-RH system resembles that described in adult primates; its role in the maturation and control of the gonadotropic cells is evoked.
journal_name
Brain Resjournal_title
Brain researchauthors
Bugnon C,Bloch B,Fellmann Ddoi
10.1016/0006-8993(77)90992-1subject
Has Abstractpub_date
1977-06-10 00:00:00pages
249-62issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(77)90992-1journal_volume
128pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90697-t
更新日期:1991-01-18 00:00:00
abstract::The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain. We studied oxidative stress intensity (malondialdehyde (MDA) concentration) as wel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.11.062
更新日期:2012-01-30 00:00:00
abstract::Marmoset monkeys (Callithrix jacchus) with bilateral transections of the anterior temporal stem, amygdala and fornix were unable to relearn a 2-choice object discrimination first learnt prior to surgery, and were very severely impaired at relearning a concurrent object discrimination task which they had learnt and rel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02998-x
更新日期:2001-01-05 00:00:00
abstract::Insulin and the insulin-like growth factors (IGFs) may directly affect the growth, development, and maintenance of the vertebrate nervous system. Previous in vitro studies have focused on embryonic nervous tissue. In this study the effects of insulin, IGF-I, IGF-II and nerve growth factor (NGF) on regeneration and neu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91496-f
更新日期:1993-04-02 00:00:00
abstract::Hydrocephalus with aqueduct stenosis was a consistent feature in mice which received a single intraperitoneal injection of 6-aminonicotinamide (6-AN) on day 5 postnatal. Chronological investigation revealed that 6-AN-treated mice had aqueductal obstruction with edematously swollen ependymal cells and spongy changes in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90180-4
更新日期:1985-10-01 00:00:00
abstract::Endogenous acetylcholine (ACh) release from rat striatal slices was measured by a chemiluminescent method. Several opiate agents were tested for their ability to modulate ACh release evoked by potassium ions (K+) or glutamic acid (GLU). Morphine, [D-Ala2,Gly(0l)5]-enkephalin (DAGO), [D-Ala2,D-Leu5]-enkephalin (DADLE) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91633-r
更新日期:1990-07-16 00:00:00
abstract::Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90989-8
更新日期:1985-12-09 00:00:00
abstract::The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90159-s
更新日期:1991-08-23 00:00:00
abstract::MicroRNAs (miRNAs) are a class of non-coding small RNAs that regulate the expression of target genes. They derive from pre-miRNAs that are enzymatically processed by dicer to ∼22 nucleotide mature miRNAs. Members of the pre-miRNA lethal-7 (let-7) are known to regulate cell proliferation and apoptosis. Here, we showed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.01.032
更新日期:2018-04-15 00:00:00
abstract::Ongoing development of the dopamine system during adolescence may provide a partial mechanism for behavioral and psychiatric vulnerabilities. Despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. While...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.07.027
更新日期:2017-01-01 00:00:00
abstract::Serotonin (5-HT) nerve terminals in the locus coeruleus (LC) of adult rat were visualized by high-resolution radioautography, in order to examine their distribution, fine structural features and intimate relationships with norepinephrine neurons. In animals pretreated with a monoamine oxidase inhibitor, prolonged intr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90791-6
更新日期:1978-04-21 00:00:00
abstract::Interactions between brain alpha2- and beta-adrenoceptors are of interest in physiological (aging) and pathological (major depression) processes involving both receptors. In this study, total beta-adrenoceptors and beta1/2-subtypes were quantitated in postmortem human brains to investigate their relationships with alp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02190-4
更新日期:2001-04-20 00:00:00
abstract::To assess the role of calcitonin gene-related peptide (CGRP) within the trigeminal subnucleus caudalis (Vc) on adrenal and autonomic function, microinjections were directed at different laminae of Vc in chloralose-anesthetized cats. Microinjections of CGRP (5 pmol, 100 nl) into laminae I-II increased significantly the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90713-6
更新日期:1991-08-30 00:00:00
abstract::The effects of spinal cord hemisection on protein labeling in the medulla, pons, midbrain, and cortex in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of brain. Animals were sacrificed 3, 6 or 13 days after hemisectio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90458-9
更新日期:1977-02-25 00:00:00
abstract::Placental Opioid-Enhancing Factor (POEF) is a substance found in amniotic fluid (AF) that, when ingested, potentiates opioid-mediated, but not non-opioid-mediated, hypoalgesia. Vaginal-cervical stimulation (VCS) produces a stimulus-bound, partially opioid-mediated hypoalgesia that previous research has shown to be pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.12.055
更新日期:2011-02-28 00:00:00
abstract::A quantitative bioassay for nerve growth factor (NGF) has been previously described which employs PC13 rat pheochromocytoma cells. The basis of this assay is that rapid neurite regeneration by PC12 cells pretreated ('primed') with NGF for at least a week is quantitatively related to the amount of NGF present in the cu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91218-0
更新日期:1983-03-14 00:00:00
abstract::The roles of the dorsal and ventral hippocampus in fear and memory are unclear. This study examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. In Experiment 1, rats received either dorsal or ventral hippocampal infusions...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.041
更新日期:2009-01-28 00:00:00
abstract::Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked inductio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91337-g
更新日期:1990-08-13 00:00:00
abstract::Repeated odorant or electrical stimulation of the frog olfactory nerve leads to long-lasting reduction of excitability of the receptor neurons. In the turtle olfactory nerve electrical stimulation causes an increase in extracellular potassium concentration due to the efflux of potassium from active axons. Elevated pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90340-h
更新日期:1990-12-24 00:00:00
abstract::Many AIDS patients suffer from cognitive impairments including deficits in learning and memory. The Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein gp120 is one possible mediator of these impairments. This is because gp120 activates brain microglial cells and astrocytes, and in vivo activation of glia lea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02445-2
更新日期:2000-04-07 00:00:00
abstract::Nineteen convergent neurones, 19 'non-noxious only' neurones and 13 'proprioceptive' neurones all with peripheral excitatory receptive fields on the ipsilateral hindpaw, were recorded in the lumbar dorsal horn of non-spinalized, anaesthetized rats. These neurones were all excited by the electrophoretic application of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91147-8
更新日期:1984-04-23 00:00:00
abstract::Occlusion of the abdominal aorta proximal to the renal arteries results in an increase in arterial blood pressure, inhibition of forepaw and hindpaw withdrawal to a noxious mechanical stimulus, and inhibition of the tail-flick reflex to noxious heat. Occlusion of the abdominal aorta distal to the renal arteries does n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90055-g
更新日期:1990-06-11 00:00:00
abstract::Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. The quinpirole-induced GP Fos expression was anta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91166-p
更新日期:1993-12-31 00:00:00
abstract::The aim of this work was to study whether the vestibular afferent fibers establish direct connections with the motoneurons of glossopharyngeal and vagus nerves of the frog, Rana esculenta. In anaesthetized animals the vestibulocochlear nerve and the common root of glossopharyngeal-vagus and accessory (IX-X-XI) nerves ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.048
更新日期:2009-08-25 00:00:00
abstract::The anesthetic-sedative barbiturate pentobarbital (PB) and the anticonvulsant barbiturate phenobarbital (PhB) were applied to mammalian spinal cord neurons in primary dissociated cell culture to assess their effects on: (1) postsynaptic GABA-responses; (2) paroxysmal activity produced by the convulsant bicuculline; (3...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91179-3
更新日期:1981-03-23 00:00:00
abstract::Effects of hypothalamic stimulation (HS) were studied in intracellular recordings obtained from 125 neurons of the motor cortex (MC). HS that was effective in reinforcing bar-press behavior, i.e. satisfactory for intracranial self-stimulation (ICSS), evoked short-latency (less than 3 ms) activation of these cortical n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91458-8
更新日期:1988-01-26 00:00:00
abstract::Ethanol and nerve growth factor (NGF) affect the survival of cholinergic neurons in the rat medial septum. To investigate whether calcium (Ca2+) homeostasis in these neurons is affected by ethanol or NGF treatment, changes in intracellular free Ca2+ concentration ([Ca2+]i) were studied in embryonic (E21) cultured medi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00955-3
更新日期:1995-12-01 00:00:00
abstract::Somatotopic projections of each maxillary molar tooth were defined by injecting individual teeth with True blue and plotting the location of fluorescent cells in sections of the trigeminal ganglia. Collateral branching was investigated by injecting True blue and Diamidino yellow into pairs of maxillary molar teeth and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90409-5
更新日期:1990-02-05 00:00:00
abstract::The growth of corticospinal tract (CST) axons was studied quantitatively at the 7th cervical (C7) and the 4th lumbar (L4) spinal segments in the balb/cByJ mice at the ages of postnatal day (P) 0, 2, 4, 6, 8, 10, 14, and 28. The cross-sectional area of the CST increased progressively with time. Unmyelinated axons, the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.036
更新日期:2006-04-21 00:00:00
abstract::The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.063
更新日期:2004-03-19 00:00:00