Rapid desensitization of presynaptic dopamine autoreceptors during exposure to exogenous dopamine.

abstract：:In adult female rats, estrogen receptor (ER) activation, particularly of ERbeta, promotes hippocampal neurogenesis. We previously reported that extranuclear ERbeta immunoreactivity (ir) in adult rats is on cellular profiles in or near the granule cell layer, which is the location of newly generated cells. During devel...

journal_title：Brain research

authors： Herrick SP,Waters EM,Drake CT,McEwen BS,Milner TA

更新日期：2006-11-22 00:00:00

abstract：:Problems in interpretation of autoradiograms generated by ligand binding in brain tissue may be caused by two types of technical limitations: the differential absorption of 3H-generated emissions within the tissue (differential quenching) and the reduced resolution when 125I and 14C are used as isotopes. In the course...

journal_title：Brain research

authors： Lidow MS,Goldman-Rakic PS,Rakic P,Gallager DW

更新日期：1988-08-30 00:00:00

abstract：:We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems). In the tail-pinch test, the antinociceptive effect of DSIP was...

journal_title：Brain research

authors： Nakamura A,Sugao T,Yamaue K,Kobatake M,Shiomi H

更新日期：1989-02-20 00:00:00

abstract：:We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...

journal_title：Brain research

authors： Gatzinsky KP,Haugland RP,Thrasivoulou C,Orike N,Budi-Santoso AW,Cowen T

更新日期：2001-11-30 00:00:00

abstract：:Electrical stimulation of the chorda tympani nerve (CT; innervating taste buds on the rostral tongue) is known to initiate recurrent inhibition in cells in the nucleus of the solitary tract (NTS, the first central relay in the gustatory system). Here, we explored the relationship between inhibitory circuits and the br...

journal_title：Brain research

authors： Rosen AM,Di Lorenzo PM

更新日期：2009-06-12 00:00:00

abstract：:The present study examined the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on the 5-HT1B and 5-HT1D autoreceptors controlling 5-HT efflux in slices of rat ventrolateral geniculate nucleus. Electrically stimulated 5-HT efflux (10 pulses, 200 Hz, 0.1 ms, 10 mA) was measured using fast cyclic voltammetry. Peak ...

journal_title：Brain research

authors： Davidson C,Stamford JA

更新日期：1997-06-20 00:00:00

abstract：:The present study was designed to investigate the role of activation of Kca+2 channels and cAMP in opioid-induced pial artery dilation in newborn pigs equipped with closed cranial windows. Methionine enkephalin, an endogenous mu agonist, elicited dilation that was modestly attenuated by the Kca+2 channel antagonist, i...

journal_title：Brain research

authors： Armstead WM

更新日期：1997-02-07 00:00:00

abstract：:Trisomy 21 (Down syndrome) results in abnormalities in electrical membrane properties of cultured human fetal dorsal root ganglion (DRG) neurons. Action potentials have faster rates of depolarization and repolarization, with decreased spike duration, compared to diploid neurons. In order to analyze the faster depolari...

journal_title：Brain research

authors： Caviedes P,Ault B,Rapoport SI

更新日期：1990-03-05 00:00:00

abstract：:Endogenous opioids play a role in the regulation of LH-RH neurosecretion throughout the estrous cycle and during the preovulatory LH surge on proestrus. Experimental evidence suggests that opioid influence may be altered with age, and it has been hypothesized that these alterations may contribute to the loss of regula...

journal_title：Brain research

authors： Rubin BS

更新日期：1993-01-22 00:00:00

abstract：:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...

journal_title：Brain research

authors： Pollack AE,Haisley EC

更新日期：2001-04-06 00:00:00

abstract：:Exercise has been shown to influence learning and memory. Most studies were performed with a voluntary running paradigm (e.g. running wheel) in mice. However, such effects of exercise on learning and memory are less well demonstrated using a forced running paradigm (e.g. treadmill). The present study was designed to e...

journal_title：Brain research

authors： Ang ET,Dawe GS,Wong PT,Moochhala S,Ng YK

更新日期：2006-10-03 00:00:00

abstract：:Cell cultures of olfactory bulb from 2-3-day-old rats were used to evaluate 6 antimitotic drugs for their effects on neuronal survival. In cultures grown in medium without drugs for 7 days, neurons died as a layer of non-neuronal cells proliferated. A series of experiments were performed to determine dilutions and exp...

journal_title：Brain research

authors： Burry RW

更新日期：1983-02-21 00:00:00

abstract：:IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...

journal_title：Brain research

authors： Akeel M,McNamee CJ,Youssef S,Moss D

更新日期：2011-02-16 00:00:00

abstract：:Cortistatin (CST) is a recently described neuropeptide with high structural homology with somatostatin. Its mRNA is restricted to gamma amino butyric acid (GABA)-containing cells in the cerebral cortex and hippocampus. CST modulates the electrophysiology of the hippocampus and cerebral cortex of rats; hence, it may be...

journal_title：Brain research

authors： Sánchez-Alavez M,Gómez-Chavarín M,Navarro L,Jiménez-Anguiano A,Murillo-Rodríguez E,Prado-Alcalá RA,Drucker-Colin R,Prospéro-García O

更新日期：2000-03-06 00:00:00

abstract：:Intracellular free calcium concentration ([Ca2+]i) was measured in cultured explants of myenteric plexus neurones by using the fluorescent calcium indicator Indol in combination with patch-clamp techniques. The basal [Ca2+]i was 94 nM and spontaneous oscillations in the internal free calcium concentration were recorde...

journal_title：Brain research

authors： Trouslard J,Mirsky R,Jessen KR,Burnstock G,Brown DA

更新日期：1993-10-08 00:00:00

abstract：:Motoneuron phenotype in the spinal cord is regulated by an intrinsic genetic program, extrinsic environmental signals and target-derived molecules. Axonal lesions trigger a phenotype switch to foster repair phenomena and axonal re-growth. We have investigated the influence of the long-term treatment with thyroid hormo...

journal_title：Brain research

authors： Giardino L,Giuliani A,Bettelli C,Calzà L

更新日期：2002-01-25 00:00:00

abstract：:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analge...

journal_title：Brain research

authors： Kreuter J,Alyautdin RN,Kharkevich DA,Ivanov AA

更新日期：1995-03-13 00:00:00

abstract：:This study investigated the long-lasting effects of chronic ethanol consumption on the distribution of Schaffer collateral-commissural (SCH/COM) afferents within stratum radiatum of rat hippocampal CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special die...

journal_title：Brain research

authors： Abraham WC,Manis PB,Hunter BE,Zornetzer SF,Walker DW

更新日期：1982-04-08 00:00:00

abstract：:Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. ...

journal_title：Brain research

authors： Sawaguchi T,Matsumura M,Kubota K

更新日期：1986-04-23 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and the central terminal fields of branches of the mandibular and chorda tympani nerves were visualized histochemically at the same time using transganglionic transport of wheat germ agglutinin conjugated with horseradish peroxidase. The blue NA...

journal_title：Brain research

authors： Takemura M,Tsujio A,Iwase K,Shimada T,Shigenaga Y

更新日期：1998-01-19 00:00:00

abstract：:The [14C]2-deoxy-D-glucose technique was used to test the effects of central muscarinic stimulation on local cerebral glucose utilization (LCGU) in rats. Systemic administration of the muscarinic agonist oxotremorine (OXO, 0.7 mg/kg, ip) increased LCGU in brain regions involved in motor function: the sensorimotor cort...

journal_title：Brain research

authors： Dow-Edwards D,Dam M,Peterson JM,Rapoport SI,London ED

更新日期：1981-12-07 00:00:00

abstract：:The possibility of retinotopic organization of pathways of retinal fibers within the optic tract and the tectum of the frog was studied by selective labeling of the retinal fibers with horseradish peroxidase. Within the optic tract the pathways of the ventral, temporal and dorsal retinal fibers were ordered from the d...

journal_title：Brain research

authors： Fujisawa H,Watanabe K,Tani N,Ibata Y

更新日期：1981-02-09 00:00:00

abstract：:The ultrastructural localizations of rat corticoliberin (rCRF) and methionine-enkephalin octapeptide (Met-Enk-8) in the external layer of the rat median eminence were examined by double-immunogold labeling with anti-rCRF and anti-Met-Enk-8 sera labeled with small-sized (Gs) and medium-sized (Gm) gold particles, respec...

journal_title：Brain research

authors： Hisano S,Daikoku S,Yanaihara N,Shibasaki T

更新日期：1986-04-09 00:00:00

abstract：:Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral f...

journal_title：Brain research

authors： Harkany T,Lengyel Z,Soós K,Penke B,Luiten PG,Gulya K

更新日期：1995-10-09 00:00:00

abstract：:Axonal and glial cell development within rat optic nerve in which gliogenesis was altered by systemic injection of 5-azacytidine (5-AZ) was examined by quantitative electron microscopy. In neonatal (0-2 days) rat optic nerves, all fibers are premyelinated, and they exhibit a fairly uniform diameter (approximately 0.22...

journal_title：Brain research

authors： Black JA,Waxman SG,Ransom BR,Feliciano MD

更新日期：1986-08-13 00:00:00

abstract：:In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain do...

journal_title：Brain research

authors： Temel Y,Visser-Vandewalle V,Kaplan S,Kozan R,Daemen MA,Blokland A,Schmitz C,Steinbusch HW

更新日期：2006-11-20 00:00:00

abstract：:The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the develop...

journal_title：Brain research

authors： Grund T,Teuchert-Noodt G,Busche A,Neddens J,Brummelte S,Moll GH,Dawirs RR

更新日期：2007-10-24 00:00:00

abstract：:We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...

journal_title：Brain research

authors： Chida K,Iadecola C,Reis DJ

更新日期：1989-10-23 00:00:00

abstract：:Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditio...

journal_title：Brain research

authors： Lee M,Suk K,Kang Y,McGeer E,McGeer PL

更新日期：2011-07-11 00:00:00

abstract：:The auditory cortical projections to the medial geniculate body (MGB) were studied in the cat. Lesions carefully restricted to each one of the subdivisions of the auditory and peri-auditory cortex were made and degenerating fibres were mapped in the MGB. In other experiments L-[4-5-3-H]leucine was injected into the co...

journal_title：Brain research

authors： Pontes C,Reis FF,Sousa-Pinto A

更新日期：1975-06-20 00:00:00