Abstract：
:In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain dopaminergic neurons in a rat model of PD. High-precision design-based stereologic examination of the total number of neurons and tyrosine tydroxylase (TH) immunoreactive neurons in the substantia nigra pars compacta revealed that STN DBS resulted in a significant survival of these neurons. These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD.
journal_name
Brain Resjournal_title
Brain researchauthors
Temel Y,Visser-Vandewalle V,Kaplan S,Kozan R,Daemen MA,Blokland A,Schmitz C,Steinbusch HWdoi
10.1016/j.brainres.2006.08.082subject
Has Abstractpub_date
2006-11-20 00:00:00pages
100-5issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)02592-3journal_volume
1120pub_type
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