Binding of [3H]flunitrazepam and [3H]Ro5-4864 to crude homogenates of amygdala-kindled rat brain: two months post-seizure.

Abstract:

:The binding of [3H]flunitrazepam and [3H]Ro5-4864 to crude homogenates of amygdala-kindled and 'yoked' control rat brains was evaluated in subjects sacrificed 60 days after the sixth generalized convulsion. Decreases in the Bmax for [3H]flunitrazepam binding to 'central-type' benzodiazepine receptors were observed in the hypothalamus and ipsilateral cortex of kindled animals. The binding of [3H]Ro5-4864 to 'peripheral-type' benzodiazepine receptors was unchanged.

journal_name

Brain Res

journal_title

Brain research

authors

Burnham WM,Niznik HB,Okazaki MM,Kish SJ

doi

10.1016/0006-8993(83)90210-x

subject

Has Abstract

pub_date

1983-11-21 00:00:00

pages

359-62

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)90210-X

journal_volume

279

pub_type

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