Abstract:
:Ischemic-reperfusion injury in humans occurs in conditions such as stroke, cardiac arrest, subarachnoid hemorrhage or head trauma. Maximal tissue damage is observed during reperfusion, which is primarily attributed to oxidative injury resulting from production of oxygen free radicals. One of the major consequences of such damage is the depletion of the cellular antioxidant, glutathione (GSH) leading to oxidation of protein thiols to disulfides and the loss of activity of critical enzymes having active thiol group(s). Thus, the maintenance of thiol homeostasis is an important factor in cell survival. The effect of thiol antioxidants like alpha-lipoic acid and the isopropyl ester of GSH was examined on the morbidity and mortality of rats subjected to reperfusion following cerebral ischemia induced by bilateral carotid artery occlusion and hypotension. While the GSH isopropyl ester had no significant protective effect; after pretreatment of rats, alpha-lipoic acid was detected in the rat brain and it dramatically reduced the mortality rate from 78% to 26% during 24 h of reperfusion. The natural thiol antioxidant, alpha-lipoic acid is effective in improving survival and protecting the rat brain against reperfusion injury following cerebral ischemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Panigrahi M,Sadguna Y,Shivakumar BR,Kolluri SV,Roy S,Packer L,Ravindranath Vdoi
10.1016/0006-8993(96)00009-1subject
Has Abstractpub_date
1996-04-22 00:00:00pages
184-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00009-1journal_volume
717pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The trace elemental concentrations, including iron, in the substantia nigra (SN) of a 6-OHDA induced rat model of Parkinson's disease were measured using nuclear microscopy. Only rats that exhibited amphetamine induced rotation of more than 7 turns/min were used. The results showed that the iron levels were significan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00313-7
更新日期:1996-09-30 00:00:00
abstract::Two-month-old male offspring of rats injected intravenously on day 19 of gestation with antiserum to synaptic membrane fraction showed marked behavioral deficits on a DRL (differential reinforcement at low rates) training paradigm. These behavioral deficits included perseveration, slow acquisition rates, and poor rete...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90325-x
更新日期:1975-07-18 00:00:00
abstract::On average, cells in areas 17, 18 or 19 of normal and stroboscopically reared cats respond with equal maximum firing rates to a narrow bar of light whether moving at the optimal velocity in the preferred direction of movement of flashed at the optimal position within the receptive field. Firing rates in the non-prefer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90223-7
更新日期:1981-09-07 00:00:00
abstract::Following brief electrical stimulation of a pleuroabdominal connective nerve, the clusters of peptidergic bag cell neurons of Aplysia generate a long-lasting (or approximately 30 min) synchronous afterdischarge. In a normal seawater medium, the afterdischarge comprises an early phase of rapid firing (2-6 Hz) lasting f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90774-0
更新日期:1982-04-22 00:00:00
abstract::The effect of microinfusions of cholecystokinin octapeptide (CCK8) and its antagonist L364,718 on duodenal and jejunal motility were evaluated by electromyography in fasted and fed rats. The rats were chronically fitted with electrodes implanted on the duodeno-jejunal wall. Steel cannulas were placed bilaterally in ei...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91124-y
更新日期:1990-01-29 00:00:00
abstract::The organization of corticotectal projections from the medial agranular cortex (AGm), which has been considered to contain rat's frontal eye field, was examined using anterograde and retrograde tracing techniques. When biotinylated dextranamine (BDA) injections were made into the rostral part of the AGm, small numbers...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02437-4
更新日期:2001-06-08 00:00:00
abstract::Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90981-g
更新日期:1990-06-04 00:00:00
abstract::To examine whether the activation of brainstem neurons during ingestion is due to orosensory afferents or post-ingestive factors, neuronal activation in response to intraoral and intragastric infusions of taste stimuli was compared in the area postrema (AP), nucleus tractus solitarius (NTS) and parabrachial nucleus (P...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02242-3
更新日期:2000-06-02 00:00:00
abstract::The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00456-z
更新日期:1995-07-24 00:00:00
abstract::Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03259-0
更新日期:2002-01-18 00:00:00
abstract::In the present immunohistochemical study the distribution of nitric oxide synthase (NOS) was studied in various autonomic ganglia and in related peripheral tissues of the rat. For comparison some other neuronal markers including acetylcholinesterase and tyrosine hydroxylase as well as several neuropeptides were analys...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91483-4
更新日期:1994-09-12 00:00:00
abstract::Neurons from many brainstem nuclei involved in respiratory control increase their firing rate in response to acidosis in vitro, suggesting that they are central chemoreceptors. This property has been considered to be either unique to neurons involved in respiratory control, or at least very unusual for non-respiratory...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02033-3
更新日期:2000-03-31 00:00:00
abstract::In a single 10-s training trial, hatchling chicks were conditioned to suppress their spontaneous peck response to a small spherical target by coating it with an aversive liquid. A 24-h test trial employing a dry target demonstrated a robust memory for the training manifested in passive avoidance behavior. Leupeptin, a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90763-3
更新日期:1987-03-17 00:00:00
abstract::Immunohistochemical studies in rats have demonstrated dopaminergic input onto medium spiny neurons of the striatum. Medium spiny neurons, however, are known to consist of two major neuropeptide-specific types, those containing substance P (SP) and those containing enkephalin. Although both of these types have been sho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90490-z
更新日期:1992-02-14 00:00:00
abstract::Recent anatomical evidence suggests that the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, and the central nucleus of the amygdala, together referred to as the extended amygdala, may play a role in opiate dependence. The bed nucleus of the stria terminalis and the shell of the nucleus accumb...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02288-x
更新日期:2000-01-31 00:00:00
abstract::Light stimulates dopamine (DA) release in the retina. The purpose of this study was to determine the threshold and dose-response relationship between ocular light exposure and retinal DA synthesis in vivo. Groups of dark-adapted rats were exposed to 0, 1, 3, 5, 10, 25, 50, 100 or 1000 microwatts per square centimeter ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91211-x
更新日期:1987-10-20 00:00:00
abstract::Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90428-e
更新日期:1990-04-23 00:00:00
abstract::Microspectrofluorimetric measurements of excitatory amino acid-evoked rises in intracellular free calcium concentration ([Ca2+]i), electrophysiological measurements of currents through single NMDA receptor-operated ion channels and estimates of cellular viability following NMDA challenge were employed to examine the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00771-h
更新日期:1995-11-06 00:00:00
abstract::Isolated brain capillary endothelial cells contain high activity levels of the blood-brain barrier (BBB) marker enzymes gamma-glutamyltranspeptidase (gamma-GT) and alkaline phosphatase (ALP). In primary culture the activities of these specific enzymes decrease with increasing cell proliferation to a constant low value...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91425-g
更新日期:1990-04-30 00:00:00
abstract::Breathing oxygen at sufficiently elevated pressures can trigger epileptiform seizures. Therefore, we tested the hypothesis that pre-treatment with FDA-approved antiepileptic drugs could prevent seizure onset in hyperoxia at 5 atmospheres absolute. We selected drugs from two putative functional categories, Na+-channel ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.12.032
更新日期:2017-02-15 00:00:00
abstract::Pentobarbital reversibly increased Na+-dependent GABA binding to bovine cerebral cortex membranes. This effect was chloride-dependent. Kinetic analysis of [3H]GABA binding revealed an increase of the apparent number of binding sites. Pretreatment of the membranes with Triton X-100 extremely diminished the effect of pe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90333-4
更新日期:1981-11-23 00:00:00
abstract::Lamprey retriculospinal neurons show phasic oscillations of their membrane potential during fictive locomotion. This modulation originates from the spinal cord locomotor networks. The aim of the present study was to elucidate the pattern of discharge of the spino-bulbar axons responsible for this modulation. Experimen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90327-6
更新日期:1992-06-05 00:00:00
abstract::Tyrosine hydroxylase immunohistochemical analysis was performed on tissue sections through the pallidal complex from Nemistrina monkeys which had been made hemi-parkinsonian by intracarotid MPTP infusion 8-12 months earlier. The side contralateral to the MPTP infusion showed a dense dopaminergic innervation of the pal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90318-p
更新日期:1991-08-16 00:00:00
abstract::The olivary pretectal nucleus is a primary visual centre sensitive to luminance changes. It is involved in the pupillary light reflex, the consensual pupillary light reflex and related reflexes, such as the lid closure reflex whereby pupillary constriction takes place. Since the olivary pretectal nucleus is a small nu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00497-e
更新日期:1995-08-07 00:00:00
abstract::In the present study, the effects of intra-central amygdala (CeA) injection of dopamine D1 receptor agonist and antagonist on morphine-induced conditioned place preference (CPP) were investigated in male Wistar rats. Our data showed that subcutaneous (s.c.) injection of morphine sulphate (0.5-10 mg/kg) significantly i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04201-4
更新日期:2003-03-07 00:00:00
abstract::The generation of oscillatory activity may be crucial to brain function. The coordination of individual neurons into rhythmic and coherently active populations is thought to result from interactions between excitatory and inhibitory cells mediated by local feedback connections. By using extracellular recording wires a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02687-7
更新日期:2001-08-24 00:00:00
abstract::Autoradiographic analysis of [(35)S]GTPgammaS binding was used to investigate functional activation of dopamine receptors in rat striatum. Dopamine-stimulated [(35)S]GTPgammaS binding was observed with a maximal increase of 38% over basal activity. A similar stimulatory response was obtained with the D(2) agonist quin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02981-4
更新日期:2000-12-01 00:00:00
abstract::This work describes the presence of glucocorticoid binding sites in human temporal cortex obtained following partial lobectomy in two epileptic patients. Using [3H]dexamethasone as radioligand and cold cortisol or RU 28362 as competitor we found an apparent Kd of approximately 2.8 nM with a Bmax of approximately 34 fm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91444-8
更新日期:1988-02-23 00:00:00
abstract::The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01372-o
更新日期:1995-02-06 00:00:00
abstract::Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91813-v
更新日期:1990-11-12 00:00:00