Abstract：
:Lamprey retriculospinal neurons show phasic oscillations of their membrane potential during fictive locomotion. This modulation originates from the spinal cord locomotor networks. The aim of the present study was to elucidate the pattern of discharge of the spino-bulbar axons responsible for this modulation. Experiments were performed on in vitro brainstem/spinal cord preparations. Two baths were formed in the recording chamber. The caudal one was perfused with 150 microM N-methyl-D-aspartate (NMDA) solution to induce fictive locomotion. The rostral bath containing the brain and the first 3-5 segments of the spinal cord was exposed to a 0 Ca2+ + 2.6 mM Mn2+ solution to block synaptic transmission and therefore to abolish any rhythmic descending activity. Spinobulbar axons were recorded intracellularly at the level of the brain/spinal cord junction. They exhibited phasic discharges correlated with the ongoing motor activity in the caudal pool. Some discharged in phase with either the ipsilateral or the contralateral ventral root bursts, others with either of the transition phases between these two bursts. These spinal cells with ascending axons, running in the ventrolateral spinal cord, may be important for modulating the activity of supraspinal neurons to match the ongoing locomotor activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Vinay L,Grillner Sdoi
10.1016/0006-8993(92)90327-6subject
Has Abstractpub_date
1992-06-05 00:00:00pages
134-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(92)90327-6journal_volume
582pub_type
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