Behavioral changes in 2-month-old rats following prenatal exposure to antibodies against synaptic membranes.

Abstract:

:Two-month-old male offspring of rats injected intravenously on day 19 of gestation with antiserum to synaptic membrane fraction showed marked behavioral deficits on a DRL (differential reinforcement at low rates) training paradigm. These behavioral deficits included perseveration, slow acquisition rates, and poor retention. Offspring of pregnant rats injected with antiserum to galactocerebroside or isotonic saline did not show these behavioral effects.

journal_name

Brain Res

journal_title

Brain research

authors

Karpiak SE Jr,Rapport MM

doi

10.1016/0006-8993(75)90325-x

subject

Has Abstract

pub_date

1975-07-18 00:00:00

pages

405-13

issue

3

eissn

0006-8993

issn

1872-6240

pii

0006-8993(75)90325-X

journal_volume

92

pub_type

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