Abstract：
:Rats received 1-stage bilateral and sequential unilateral (serial) lesions of the posterior hypothalamus and were tested for the ability to regulate body temperature after a lengthy recovery period. The groups with lesion differed from the sham-operated groups in the cold, although not under ambient or warm conditions. The fact that the serial lesion group performed the same as the 1-stage lesion groups in the cold is significant because earlier tests on these same animals revealed much better recovery after serial lesions in swimming, and a partial serial lesion effect in open field performance.
journal_name
Brain Resjournal_title
Brain researchauthors
Bell J,Gruenthal M,Finger S,Mangold Rdoi
10.1016/0006-8993(81)90309-7subject
Has Abstractpub_date
1981-08-31 00:00:00pages
451-5issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90309-7journal_volume
219pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Glucose inhibits ∼60% of lateral hypothalamic (LH) orexin neurons. Fasting increases the activation of LH orexin glucose-inhibited (GI) neurons in low glucose. Increases in spontaneous glutamate excitatory postsynaptic currents (sEPSCs) onto putative VTA DA neurons in low glucose are orexin dependent (Sheng et al., 20...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.025
更新日期：2020-03-15 00:00:00
abstract：:The opioid peptides Leu-enkephalin, Met-enkephalin and D-Ala2-Met-enkephalinamide were injected at various concentrations into the neocortex and hippocampus of rats to examine their effects on EEG activity and DC potentials. All three compounds were found to elicit spreading depression (SD) in both structures. Higher ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90897-0
更新日期：1981-04-06 00:00:00
abstract：:Recently, the gene encoding the cerebrovascular and neuritic plaque amyloid, a pathologic stigma of Alzheimer's disease (AD), has been molecularly cloned and mapped to human chromosome 21, band q21. Changes in the brains of individuals with trisomy 21 (Down syndrome, DS) over 35 years of age closely resemble AD neurop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90028-3
更新日期：1987-09-01 00:00:00
abstract：:The behavioral and physiological effects of electrical stimulation of the nucleus locus coeruleus (LC) were studied in the awake rat. LC electrodes consistently supported high rates of self-stimulation (SS). LC stimulation also inhibited spontaneous cellular discharges in the hippocampus (HPC). Both the LC-induced inh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90140-2
更新日期：1976-05-14 00:00:00
abstract：:Caspases, a family of cysteine proteases, are widely activated in neurons and glia in the injured brain, a response thought to induce apoptosis. However, caspase activation in astrocytes following injury is not strongly associated with apoptosis. The present study investigates the potential role of caspase activation ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.056
更新日期：2012-04-23 00:00:00
abstract：BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.064
更新日期：2010-09-02 00:00:00
abstract：:We examined in the present study alterations in cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague-Dawley rats. Laser Doppler revealed that transplanted animals exhibited near normal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.02.050
更新日期：2004-05-29 00:00:00
abstract：:Huntington's disease (HD) is a fatal, genetic, neurodegenerative disorder characterized by deficits in motor and cognitive function. Here, we have quantitatively characterized motor deficiencies and dopamine release dynamics in transgenic HD model rats. Behavioral analyses were conducted using a newly-developed force-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.042
更新日期：2012-04-23 00:00:00
abstract：:D-Fen-induced hyperthermia has been shown to coincide with an enhanced depletion of 5-HT and 5-hydroxyindole acetic acid (5-HIAA). Because these observations have relied on D-Fen exposure at multiple environmental temperatures, some have questioned the validity of the findings. Therefore, this experiment was designed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01732-1
更新日期：1999-08-28 00:00:00
abstract：:The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.074
更新日期：2010-01-22 00:00:00
abstract：:In vitro uptake of labeled serotonin (5-HT) has allowed the radioautographic detection of serotoninergic fibers in the cat spinal cord at thoracic and lumbar levels. The specificity of labeling was ensured by the conditions of incubation ([3H]5-HT was 10(-7) M) and by test control experiments with concomitant 10(-6) M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90331-1
更新日期：1978-09-29 00:00:00
abstract：:A pair of neurons exhibiting postinhibitory rebound, if connected through reciprocally inhibitory chemical synapses, will exhibit a stable pattern of alternating bursts. If two such oscillating pairs, of similar but not identical properties are connected by means of an electrical synapse and an inhibitory chemical syn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90742-3
更新日期：1981-12-14 00:00:00
abstract：:Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.040
更新日期：2015-11-02 00:00:00
abstract：:Cerebellar Purkinje neurons (PNs) are selectively vulnerable to AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepriopionic acid)-induced delayed neurotoxicity known as dark cell degeneration (DCD) that is expressed as cytoplasmic and nuclear condensation, neuron shrinkage, and failure of physiology. The present study ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.048
更新日期：2003-12-24 00:00:00
abstract：:Following transection of a peripheral nerve in mice, a newly synthesized neurotropic pyrimidine compound, MS-818 was administered intraperitoneally at a dose of 1 mg kg-1 b.wt. day-1. The film model experiments for analyzing the early growth of axonal regeneration suggested that MS-818 activated Schwann cells which mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01491-1
更新日期：1998-03-23 00:00:00
abstract：:Extracellular single unit recordings were made from various depths in the left olfactory bulb of ten anaesthetised, freely breathing adult hens (Gallus domesticus) using glass insulated tungsten microelectrodes. The 66 spontaneously active neurons recorded had widely variable firing rates (mean 4.9 spikes/s, range 0.1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03376-5
更新日期：2002-03-01 00:00:00
abstract：:Starvation inhibits egg-laying in the snail, Lymnaea stagnalis. In starved animals the neurosecretory Caudo-Dorsal Cells (CDC), which produce the egg-laying hormone, are hyperpolarized as compared to the CDC of controls. However, they are more responsive to repetitive intracellular stimulation, which induces the hormo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90528-5
更新日期：1982-05-13 00:00:00
abstract：:The opposing actions of diphenylhydantoin (DPH) and calcium on the level of [32P]phosphate incorporation into particular rat and human brain proteins have been demonstrated in this study by employing the techniques of acrylamide gel electrophoresis and autoradiography. In the presence of calcium several brain proteins...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90930-1
更新日期：1977-09-23 00:00:00
abstract：:It was previously proposed that norepinephrine (NE)-containing nerve terminals in visual cortex are important for the maintenance of cortical plasticity. Observations at that time indicated that local microperfusion of exogenous NE for 1 week directly into kitten visual cortex, with no alteration of the visual environ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91288-5
更新日期：1984-06-04 00:00:00
abstract：:To achieve a better understanding of the parallel information processing that takes place in the nervous system, many researchers have recently begun to use multielectrode techniques to obtain high spatial- and temporal-resolution recordings of the firing patterns of neural ensembles. Apart from the complexities of ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03072-9
更新日期：2000-12-22 00:00:00
abstract：:The activities of 5'-nucleotidase (EC 3.1.3.5) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) (EC 3.1.4.37) were measured in crude membrane preparations from 6 brain regions of hypothyroid rats 31 days and 42 days after conception (8-9 days and 19-20 days after birth respectively) and from normal rats 31, 36...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90185-2
更新日期：1983-04-01 00:00:00
abstract：:Superfusion of rat hypothalamic slices with 10(-4) M N-methyl-D-aspartic acid (NMDA) resulted in increased release of alpha-melanocyte-stimulating hormone (alpha-MSH). Peptide release was blocked by 10(-6) M NG-nitro-L-arginine methyl ester (L-NAME) a specific competitive inhibitor of nitric oxide synthase but not by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90773-0
更新日期：1994-12-15 00:00:00
abstract：:Fluorescence and immunohistochemical techniques were used to study the pattern and density of perivascular nerves containing noradrenaline (NA) and neuropeptide Y (NPY) supplying the major cerebral arteries of 4-, 6-, 8- and 12-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar (WIS) controls. Leve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90910-9
更新日期：1988-03-15 00:00:00
abstract：:Metabolic stress imposed by epileptic seizures can result in mitochondrial dysfunction, believed to act as positive feedback on epileptogenesis and seizure susceptibility. As the mechanism behind this positive feedback is unclear, the aim of the present study was to investigate the causal link between acute mitochondr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147193
更新日期：2021-01-15 00:00:00
abstract：:Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02742-6
更新日期：2000-10-27 00:00:00
abstract：:In order to obtain further insight into the interactions between the purinergic and dopaminergic pathways in the striatum, we studied both metabolisms simultaneously, using a microdialysis technique in 1-methyl-1,4-phenylpyridinium ion (MPP+) unilaterally-denervated conscious rats. In these rats the contralateral side...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90052-8
更新日期：1989-03-27 00:00:00
abstract：:In situ hybridization (ISH) is an essential technique for mapping gene expression in the brain. Although many ISH protocols provide for quantitative analysis of individual mRNAs in different brain regions or across experimental conditions, this technique has lacked the necessary standardization for quantitative compar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.069
更新日期：2004-03-12 00:00:00
abstract：:Oxidative stress and massive production of nitric oxide (NO) have been implicated in the neuropathogenesis following peripheral nerve injury. This study was aimed to ascertain whether melatonin would exert its neuroprotective effect on the lesioned hypoglossal neurons after peripheral axotomy, since it is known to red...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02489-6
更新日期：2000-08-11 00:00:00
abstract：:The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its putative toxic metabolite 1-methyl-4-phenylpyridinium ion MPP+ were studied with specific neuronal and glial cell lines in vitro. MPTP had no morphological effect on actively growing neuroblastoma N2AB-1 cells or C6 glioma cells nor did it affe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90225-9
更新日期：1988-07-26 00:00:00
abstract：:Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of add...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00150-4
更新日期：1998-05-11 00:00:00
