A newly synthesized neurotropic pyrimidine compound, MS-818, may activate migratory schwann cells in peripheral nerve regeneration.

Abstract:

:Following transection of a peripheral nerve in mice, a newly synthesized neurotropic pyrimidine compound, MS-818 was administered intraperitoneally at a dose of 1 mg kg-1 b.wt. day-1. The film model experiments for analyzing the early growth of axonal regeneration suggested that MS-818 activated Schwann cells which migrate from the proximal stump, inducing axonal elongation in vivo.

journal_name

Brain Res

journal_title

Brain research

authors

Torigoe K,Awaya A

doi

10.1016/s0006-8993(97)01491-1

subject

Has Abstract

pub_date

1998-03-23 00:00:00

pages

337-40

issue

2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(97)01491-1

journal_volume

787

pub_type

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