Effects of hypodynamia-hypokinesia on somatosensory evoked potentials in the rat.

Abstract:

:The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic nerve in control rats and in rats submitted to 7 or 14 days of HH. HH was obtained by unloading the hindquarter. HH induced some subtle modifications in the SEP characteristics. Latency was increased for the spinal and cortical SEPs after 7 days of HH, and restored after 14 days of HH. A decrease in the amplitude was observed after 14 days of HH for the cortical SEP only. At the end of the experiment, the compound action potential of the sciatic nerve was recorded in vitro in order to evaluate the mean conduction velocity. Results indicate that the nerve velocity was reduced after 14 days of HH. The results also suggest that sensory conduction and/or cortical and spinal excitability are changed after HH.

journal_name

Brain Res

journal_title

Brain research

authors

Canu MH,Langlet C,Dupont E,Falempin M

doi

10.1016/s0006-8993(03)02804-x

subject

Has Abstract

pub_date

2003-07-18 00:00:00

pages

162-8

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S000689930302804X

journal_volume

978

pub_type

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