Abstract：
:The rat medial prefrontal cortex is known to have diverse brain functions such as learning and memory, attention, and behavioral flexibility. Although these functions are affected by monoamines (dopamine (DA), noradrenaline (NA) and serotonin (5-HT)) and acetylcholine (ACh), the detailed mechanisms remain unclear. These neuromodulators also have effects on synapse formation and maintenance, and regulate plasticity in the central nervous system (CNS). To clarify the effects of these neuromodulators on changes in the density of synapses in the rat medial prefrontal cortex, we separately administered a D1- or D2-antagonist, NA neurotoxin, 5-HT synthetic inhibitor, or muscarinic ACh antagonist for 1 week, and counted the number of synapses on electron microscopic photographs taken from the prelimbic area of the medial prefrontal cortex. The density of synapses in lamina I was regulated by DA via D1-like receptors, and that in laminae II/III was decreased by depletion of NA or ACh. However, 5-HT did not have a regulatory effect on the synaptic density throughout the layers in this brain region. The data in this study and our previous studies indicate that there are appreciable regional differences in the magnitude of biogenic amine-mediated synaptic plasticity in the rat CNS. These neuromodulators may have a trophic-like effect on the selected neuronal circuit to maintain synaptic contacts in the rat CNS. The synaptic density in the medial prefrontal cortex regulated by monoamines and ACh could be important not only for synaptic plasticity in this region but also for pharmacotherapeutic drug treatment.
journal_name
Brain Resjournal_title
Brain researchauthors
Imai H,Matsukawa M,Okado Ndoi
10.1016/j.brainres.2004.03.039subject
Has Abstractpub_date
2004-06-25 00:00:00pages
138-45issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304005128journal_volume
1012pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Glutamate is the main excitatory neurotransmitter in the central nervous system. This amino acid mediates learning and memory processes acting through ionotropic and metabotropic receptor binding. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that stimulate phospholipase C (PLC) or inhibit ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.010
更新日期：2007-06-11 00:00:00
abstract：:The present study was undertaken in order to study the rate of maturation of the cochlear action potential sensitivity, latency, and tuning curves for various stimulus frequencies and to correlate the development of latency and frequency selectivity with threshold development. This study showed a two-stage model of ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90239-2
更新日期：1987-12-15 00:00:00
abstract：:The distribution of [3H]kainic acid (KA) binding sites in the rat CNS was determined by in vitro autoradiography. KA sites are distributed throughout the CNS gray matter in an anatomically specific pattern with telencephalic structures and the cerebellum accounting for the majority of the binding. These results, toget...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90981-7
更新日期：1982-12-02 00:00:00
abstract：:Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigated the role of NO and of its newly recognized precursor, nitrite, in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.045
更新日期：2011-08-17 00:00:00
abstract：:Previous studies have shown that the feline caudate nucleus contains DPI-sensitive (caput nuclei caudati, anterodorsal part; r-CRM) and DPI-insensitive (caput nuclei caudati, rostromedial part; CRM) regions. Stimulation of dopamine receptors within the r-CRM by dopamine or DPI are known to elicit oro-facial dyskinesia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90689-s
更新日期：1991-01-18 00:00:00
abstract：:Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in reduced expression of the SMN protein. The SMN protein is an essential molecular chaperone that is required for the biogenesis of multiple ribonucleoprotein (RNP) complexes including spliceosomal small nuclear RNPs (snRNPs). Re...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.02.022
更新日期：2018-08-15 00:00:00
abstract：:Initial studies found glutamate injury to murine spinal cultures (14-17 days in vitro) to reflect contributions of both NMDA and AMPA/kainate receptors. Subsequent experiments found the spinal cultures to be more sensitive than cortical cultures to injury from prolonged low level kainate exposures, and, unlike cortica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00532-u
更新日期：1995-08-21 00:00:00
abstract：:The activities of GABA-transaminase (GABA-T) were examined in several brain regions of amygdala-kindled rats, pretreated either with or without gabaculine, an irreversible GABA-T inhibitor. Histochemical and biochemical studies demonstrated that GABA-T activities decreased significantly in some brain regions 16 h afte...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90692-x
更新日期：1986-08-27 00:00:00
abstract：:The activity of incertohypothalamic, tuberoinfundibular, mesolimbic and nigrostriatal dopamine (DA) neurons was estimated by measuring the rate of turnover of DA (decline of DA after alpha-methyltyrosine) in brain regions containing the cell bodies and terminals of these neurons. Estradiol benzoate (25 micrograms/kg/d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90267-1
更新日期：1984-12-03 00:00:00
abstract：:Rats provided limited daily access to cocaine (1 h) maintain stable levels of drug self-administration over time while those switched to longer access (6 h or more) exhibit escalating patterns of drug intake. These results are reminiscent of human recreational and compulsive drug-taking behavior, respectively. We foun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.053
更新日期：2004-01-02 00:00:00
abstract：:The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium om...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02553-7
更新日期：2001-07-06 00:00:00
abstract：:Recent studies have demonstrated that sensory hair cells in the avian inner ear are reproduced by cell proliferation in response to the death of the original hair cell population. The regenerated hair cells appear to construct functional synaptic contacts, thereby transmitting acoustic signals to the peripheral nervou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01467-5
更新日期：1996-05-13 00:00:00
abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03616-8
更新日期：2002-12-06 00:00:00
abstract：:Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.070
更新日期：2008-07-07 00:00:00
abstract：:Current responses to acetylcholine (ACh) and to suberyldicholine (D-6) applied from the double-barrelled ionophoretic micropipette were studied in two identified neurones (LPed-2 and LPed-3) isolated from the left ganglion of pulmonate mollusc, Planorbarius corneus. Experiments made with K2SO4-filled microelectrodes s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91232-x
更新日期：1982-06-03 00:00:00
abstract：:The functional organization of projections from the cerebellar subcortical nuclei to the motor cortex through the nucleus ventralis lateralis (VL) of the thalamus was studied using tungsten microelectrodes for stimulation and recordings in acute and chronic cats. The following results were obtained. (1) Microstimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90510-7
更新日期：1975-11-07 00:00:00
abstract：:Leptin is one of the key afferent signals that regulate food intake and energy expenditure by acting on specific receptors in the hypothalamus. Recently, leptin was reported to activate the peripheral immune system by acting directly on lymphocytes. To elucidate the brain-mediated participation of leptin in the modula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02409-9
更新日期：2000-02-07 00:00:00
abstract：:Spontaneous, synchronous burst discharges originating in the CA2-CA3 region of guinea pig hippocampal slices occur when the concentration of magnesium in the perfusate is reduced below 250 microM. The burst frequency is greater than that seen with other convulsants and afterdischarge is common. Cyclic periods of burst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80042-2
更新日期：1987-04-28 00:00:00
abstract：:Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90665-6
更新日期：1984-01-16 00:00:00
abstract：:Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. Whi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.12.031
更新日期：2015-03-10 00:00:00
abstract：:The enzyme in brain that hydrolyzes 2',3'-cyclic nucleotides to the 2'-mononucleotides has been found by several authors to be concentrated in the myelin fraction. To facilitate further study of the enzyme, one of our objectives has been to develop a method of solubilizing the enzyme without the use of detergents. Whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90719-2
更新日期：1975-05-23 00:00:00
abstract：:In auditory speech processing, phonological stress functions as an attention holding cue, which facilitates detection of mispronunciations and phonetic deviants in strong syllables as compared to weak ones. Whereas silent reading involves activation of phonological information including word stress, it is not clear wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.003
更新日期：2016-04-01 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) of human lower limb motor cortex paired with common peroneal nerve electrical stimulation produces a lasting modulation of motor cortex excitability following the principles of spike-timing-dependent plasticity. We previously demonstrated that this "paired associative stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.062
更新日期：2007-06-11 00:00:00
abstract：:Hippocampal corticosteroid receptors are regulated by corticosterone as well as by neurotransmitters, such as serotonin (5-HT). Studies have demonstrated that long-term changes in 5-HT levels are associated with alterations in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) number. However...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00371-v
更新日期：1995-06-26 00:00:00
abstract：:The ventral tegmental area has been suggested as a possible site of action for the rewarding effect of opiates on the basis of the fact that local morphine injections in this but not other regions are rewarding. That this is a necessary and not just a sufficient site of opiate rewarding action was suggested by the fac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91232-5
更新日期：1983-01-03 00:00:00
abstract：:The possible interference of nitric oxide (NO) in glucose metabolism was studied in activated astrocytes. Lipopolysaccharide (LPS) treatment triggered a NO-mediated increase in glucose consumption and lactate production, suggesting an enhanced rate of glycolysis. Active glycogen synthesis was also observed after LPS t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02877-9
更新日期：2002-07-26 00:00:00
abstract：:Cell transplantation using ventral mesencephalic tissue is an experimental approach to treat Parkinson's disease. This approach is limited by poor survival of the transplants and the high number of dopaminergic neurons needed for grafting. Increasing the yield of dopaminergic neurons in donor tissue is of great import...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.05.015
更新日期：2017-08-01 00:00:00
abstract：:This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid compositio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90419-5
更新日期：1983-09-19 00:00:00
abstract：:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.034
更新日期：2012-08-27 00:00:00
abstract：:Specific binding of [3H]naloxone to rat brain tissue in vitro was inhibited by the excitant organochlorinated insecticides (OCI), by ether (E) and octanol (OCT), and by the convulsant indoklon (IND) and its anesthetic isomer, isoindoklon (ISO). In the presence of 100 mM NaCl the inhibition of naloxone binding by E, OC...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90277-8
更新日期：1981-08-24 00:00:00
