Two rates of fast axonal transport of [3H]glycoprotein in an identified invertebrate neuron.

Abstract:

:Recently, the kinetics of fast axonal transport of a single type of organelle, the serotonergic storage vesicle, was described in an identified axon of Aplysia using a pulsing technique combined with intracellular injection of [3H]serotonin. Here we extended the single axon studies by analyzing the movement of pulses of [3H]glycoprotein, following injection into the giant Aplysia cell, R2, of the amino sugar [3H]N-acetylgalactosamine. This glycoprotein precursor has been shown to label several organelles in this neuron. [3H]Glycoprotein is found to move in the axon of R2 at 2 rates of fast transport, 174 and 105 mm per day at room temperature. We suggest that the 2 rates reflect movements of 2 different types of organelle.

journal_name

Brain Res

journal_title

Brain research

authors

Goldberg DJ,Ambron RT

doi

10.1016/0006-8993(81)91006-4

subject

Has Abstract

pub_date

1981-12-21 00:00:00

pages

445-55

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)91006-4

journal_volume

229

pub_type

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