Abstract：
:Ionic currents induced by glutamate, kainate, quisqualate, and N-methyl-D-aspartate (NMDA) in cultured septal neurons were analyzed by fluctuations analysis. The power spectrum (PWS) of NMDA current fluctuations always fitted a single Lorentzian. PWSs of the other agonists fitted the sum of two Lorentzians; however, the slopes of PWSs became larger and the PWSs became closer to single Lorentzians as the number of drug application increased. This may be explained in such a way that, in multiple conductance channels activated by these agonists, the high frequency component decreases the gating activity in later recordings, whereas the low frequency component keeps its gating kinetics.
journal_name
Brain Resjournal_title
Brain researchauthors
Shingai R,Ebina Ydoi
10.1016/0006-8993(88)91120-1subject
Has Abstractpub_date
1988-05-10 00:00:00pages
198-203issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)91120-1journal_volume
448pub_type
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