Abstract:
:We investigated the projection from the infralimbic division of the prefrontal cortex (area 25) to histaminergic neurons in the posterior hypothalamic area. Phaseolus vulgaris-leucoagglutinin (PHA-L) was injected in the prefrontal cortex of rats. Frozen brain sections were subjected to combined PHA-L and histidine decarboxylase (HDC)-peroxidase immunocytochemistry, using nickel-enhanced diaminobenzidine (blue reaction product) to visualize the transported PHA-L, and diaminobenzidine (brown reaction product) to visualize simultaneously the HDC-containing neurons. PHA-L-labeled fibers could be seen coursing in the capsula interna, leaving the telencephalon via the anterior thalamic radiation and the medial forebrain bundle. In the lateral and posterior hypothalamic areas, PHA-L-labeled fibers leave the medial forebrain bundle and traverse the nuclei containing HDC-immunoreactive neurons. Varicosities on the PHA-L-labeled fibers, the majority of which occur en passant, could be observed in close association with the HDC-immunoreactive neurons. The results suggest that the hypothalamic histaminergic neurons receive afferent synaptic input from neurons of the infralimbic division of the prefrontal cortex.
journal_name
Brain Resjournal_title
Brain researchauthors
Wouterlood FG,Steinbusch HW,Luiten PG,Bol JGdoi
10.1016/0006-8993(87)90802-xsubject
Has Abstractpub_date
1987-03-17 00:00:00pages
330-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90802-Xjournal_volume
406pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The control of hypoglossal motoneurons during sleep is important from a basic science perspective as well as to understand the bases for pharyngeal occlusion which results in the obstructive sleep apnea syndrome. In the present work, we used intracellular recording techniques to determine changes in membrane propertie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02955-3
更新日期:2000-12-08 00:00:00
abstract::In a previous study the collateralization of the rubrospinal tract in the spinal cord of rat, cat and monkey was studied by means of the fluorescent retrograde double labeling technique. In the present study the existence of rubrospinal collaterals to the cerebellar interpositus nucleus (NI) has been studied using the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90816-8
更新日期:1983-04-04 00:00:00
abstract::Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01315-7
更新日期:1997-02-07 00:00:00
abstract::In vitro uptake of labeled serotonin (5-HT) has allowed the radioautographic detection of serotoninergic fibers in the cat spinal cord at thoracic and lumbar levels. The specificity of labeling was ensured by the conditions of incubation ([3H]5-HT was 10(-7) M) and by test control experiments with concomitant 10(-6) M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90331-1
更新日期:1978-09-29 00:00:00
abstract::Spontaneous and hypothalamically induced hippocampal rhythmical slow activity (RSA or theta) was studied acutely in rats anaesthetized with urethane or immobilized with D-tubocurarine. Systematic tracking of microelectrodes showed two foci of hippocampal RSA, one located in the basal part (stratum oriens) of CAl (mean...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90711-3
更新日期:1976-12-17 00:00:00
abstract::The disector method was used to estimate the numerical density of neurons (number per unit volume) and their actual number per column (number under a given area of pial surface), in the occipital (monocular segment of the primary visual area, Oc1M), the parietal (somatosensory barrelfield area, Par1) and the frontal c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90884-p
更新日期:1993-04-23 00:00:00
abstract::The actions of dopamine are mediated by 5 or more receptor subtypes, any of which may be coupled by G-proteins to adenylate cyclase (D1-family: stimulatory, D2-family: inhibitory or no action). Postnatal ocular growth in the chick is a vision-dependent mechanism which involves D2-type receptors in either the retina or...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00700-z
更新日期:1995-10-16 00:00:00
abstract::We have examined the question of whether alpha-tubulin is detyrosylated during axonal transport in retinal ganglion cell axons and axons of spinal motor neurons. The degree of tyrosylation of alpha-tubulin was estimated from immunocytochemistry and immunoblotting with two anti-alpha-tubulin monoclonals, one of which (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90697-9
更新日期:1986-08-27 00:00:00
abstract::The tegmentopontine reticular nucleus (nucleus of Bechterew) plays a crucial role in the generation of horizontal saccades and smooth pursuit movement of the eyes. The evolution of Alzheimer's disease-related cytoskeletal pathology was studied of this nucleus was studied in 27 autopsy cases at different stages of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02598-7
更新日期:2001-07-27 00:00:00
abstract::The purpose of the present investigation was to record electrophysiological responses from single fibers in the hamster superior laryngeal nerve (SLN) that were responsive to chemical stimulation of the larynx. Twenty chemical solutions, commonly used in studies of mammalian gustatory physiology, were applied to taste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91541-7
更新日期:1988-05-31 00:00:00
abstract::The origin of neuronal perikarya which project to the external zone of the median eminence (the tuberoinfundibular neuronal system) was determined in the rat after injection or diffusion of wheat germ agglutinin (WGA) into the median eminence. The retrogradely transported lectin was detected in neurons using an immuno...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90334-1
更新日期:1982-08-05 00:00:00
abstract::Amphetamine withdrawal is associated with heightened anxiety-like behavior, which is directly driven by blunted stress-induced glucocorticoid receptor-dependent serotonin release in the ventral hippocampus. This suggests that glucocorticoid availability in the ventral hippocampus during stress may be reduced during am...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.05.030
更新日期:2016-08-01 00:00:00
abstract::The visual properties of cells in the cat ventral lateral geniculate nucleus (LGV) identified antidromically from the pretectum and/or superior colliculus (projection cells) were studied in comparison with those of LGV neurons which could not be activated antidromically (non-projection cells). ON-phasic receptive fiel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90672-4
更新日期:1986-01-15 00:00:00
abstract::Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.085
更新日期:2007-01-26 00:00:00
abstract::Long-term potentiation (LTP) has a memory-like consolidation period during which it becomes progressively stabilized. However, it is unknown how the consolidation is achieved. The present study demonstrates that nicotine reverses stabilized LTP in the hippocampal CA1 region, providing the first evidence that consolida...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.02.034
更新日期:2006-03-17 00:00:00
abstract::In order to examine the relationship between myelination and sensitivity to anoxia in adult white matter, we studied action potential conduction in the spinal cord dorsal column of adult rats in which focal demyelinating lesions had been produced using ethidium bromide/X-irradiation. Acutely isolated spinal cords from...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01171-2
更新日期:1998-01-01 00:00:00
abstract::The size differences in the midsagittal cerebellum, its individual lobules and its layers are studied in homozygous diabetic (HOM) and heterozygous Brattleboro rats on postnatal days 12, 24 and 180. As has been reported for total cerebellar weight, no significant reduction in cerebellar size in HOM rats occurs at day ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90296-8
更新日期:1986-05-01 00:00:00
abstract::The motor unit discharges in human hand muscles were recorded during voluntary isometric contraction. Bipolar wire electrodes were inserted in the right adductor pollicis muscle (AP) and first dorsal interosseous muscle (FDI) for the recordings. Motor unit activities from these muscles were investigated when subjects ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91461-7
更新日期:1986-04-30 00:00:00
abstract::Nestin is an intermediate filament protein, transiently and abundantly expressed early in embryogenesis, e.g., in neuroepithelial cells, radial glia, germinal matrix cells and vascular cells. In the adult rat brain, nestin is only present in endothelial and select subventricular cells. We tested the hypothesis that af...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01502-4
更新日期:1999-08-14 00:00:00
abstract::The effect of different dose, mode and duration of estradiol administration was examined in the different brain catecholaminergic areas in ovariectomized (OVX) female rats. We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.04.002
更新日期:2004-07-23 00:00:00
abstract::Enkephalin-like immunoreactive nerve fibers in the celiac ganglion of guinea pigs were characterized by a high population of large granular vesicles mixed with small clear vesicles. The immunoreactive material is confined to the large granular vesicles. The immunoreactive nerve fibers formed many axo-dendritic as well...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90987-8
更新日期:1982-12-02 00:00:00
abstract::The present study was designed to investigate the existence of two key enzymes involved in the metabolism of gamma-aminobutyric acid, glutamic acid decarboxylase (GAD) and glutamine synthetase (GS), in the area postrema (AP) of the cat. The results showed that punctuate structures of variable size corresponding to axo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90320-9
更新日期:1987-05-05 00:00:00
abstract::The effects of axotomy, chemical sympathectomy and preganglionic denervation on the expression of the neuropeptides, pituitary adenylate cyclase-activating peptide (PACAP), galanin (GAL), and the PACAP type 1 receptor in the rat superior cervical ganglion (SCG) were investigated by immunocytochemistry, in situ hybridi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00923-2
更新日期:1997-11-14 00:00:00
abstract::Glutamate induced responses in the surface membrane of Xenopus oocyte by injection with mRNA from crustacea and insect muscle. Glutamate (10(-5) to 10(-4) M) elicited smooth current responses which resembled those induced by kainate. This smooth current reversed direction at about 0 mV and was blocked by a spider toxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(87)90048-9
更新日期:1987-12-01 00:00:00
abstract::The impact of maternal nutrition on neurodevelopment and neonatal neuroprotection is a research topic with increasing interest. Maternal diet can also have deleterious effects on fetal brain development. Fetal exposure to alcohol is responsible for poor neonatal global development, and may increase brain vulnerability...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146798
更新日期:2020-07-01 00:00:00
abstract::Six cats were trained to eat while partially restrained and while thermal pulse stimuli (43-60 degrees C, 5 s duration) were delivered to the upper hindlimbs. Food and stimulus delivery were under programmed electronic control. The probability and latency of 3 natural, unlearned nocifensive behaviors were electronical...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91036-6
更新日期:1989-10-30 00:00:00
abstract::Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90752-7
更新日期:1983-10-16 00:00:00
abstract::Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01466-7
更新日期:1997-03-28 00:00:00
abstract::Previous studies we performed on the mdx mouse demonstrated marked central nervous system alterations in this model of human Duchenne muscular dystrophy, such as reduction in number and pathological changes of cortico-spinal neurons. Prompted by these findings we extended the survey of the mdx brain to the major brain...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02108-4
更新日期:2001-03-23 00:00:00
abstract::Putative N-type voltage-sensitive calcium channels were localized autoradiographically in thaw-mounted rat brain slices using [125I]omega-conotoxin GVIA as a ligand. Density of the toxin binding sites were highly heterogeneous throughout the brain. The highest density of the binding sites was observed in the glomerula...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90790-1
更新日期:1988-06-07 00:00:00