Abstract：
:In order to examine the relationship between myelination and sensitivity to anoxia in adult white matter, we studied action potential conduction in the spinal cord dorsal column of adult rats in which focal demyelinating lesions had been produced using ethidium bromide/X-irradiation. Acutely isolated spinal cords from control rats and following demyelination were maintained in vitro at 36 degrees C and compound action potentials were studied following supramaximal stimulation. The compound action potential was totally abolished within 12 min of the onset of anoxia in normal dorsal columns, but was not abolished until 50 min following the onset of anoxia in demyelinated dorsal columns. Compound action potentials showed significantly greater recovery (to 58.1 +/- 12.2% of control amplitude) in demyelinated dorsal columns compared to controls (30.8 +/- 5.3%) following 120 min of reoxygenation. These results show that focal demyelination is associated with reduced sensitivity to anoxia within white matter of the adult spinal cord.
journal_name
Brain Resjournal_title
Brain researchauthors
Imaizumi T,Kocsis JD,Waxman SGdoi
10.1016/s0006-8993(97)01171-2subject
Has Abstractpub_date
1998-01-01 00:00:00pages
292-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01171-2journal_volume
779pub_type
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