Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG).

abstract：:Regulation of tyrosine hydroxylase (TH) by second messenger pathway activators was examined in rat olfactory bulb cell cultures. The number of TH-immunoreactive neurons was increased 2-3-fold by 36 h treatments with forskolin (Fsk, 10(-6) M) or phorbol myristate acetate (PMA, 10(-7) M), but was not significantly incre...

journal_title：Brain research

authors： McMillian MK,Mullis SB,Wu GC,Hudson PM,Pennypacker KR,Hong JS

更新日期：1994-09-26 00:00:00

abstract：:We studied the effect of the cortical projection from the basal forebrain on the cerebral cortical metabolism using positron emission tomography (PET) with [(18)F] fluorodeoxyglucose. Unilateral damage of the nucleus basalis magnocellularis (NBM) did not cause a permanent reduction of cortical metabolism: recovery was...

journal_title：Brain research

authors： Katsumi Y,Hanakawa T,Fukuyama H,Hayashi T,Nagahama Y,Yamauchi H,Ouchi Y,Tsukada H,Shibasaki H

更新日期：1999-08-07 00:00:00

abstract：:Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/microl, 0.5 microl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. Thes...

journal_title：Brain research

authors： Mourre C,Fournier C,Soumireu-Mourat B

更新日期：1997-12-19 00:00:00

abstract：:We studied whether interleukin-1 (IL-1) affects the release of arginine vasopressin (AVP) from the superfused hypothalamo-neurohypophyseal complex (HNC) of rats. Involvement of the cholinergic system in the mediation of IL-1 on AVP release from HNC was also examined. Both human recombinant IL-1 alpha and -1 beta elici...

journal_title：Brain research

authors： Nakatsuru K,Ohgo S,Oki Y,Matsukura S

更新日期：1991-07-19 00:00:00

abstract：:An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by a 6-day withdrawal. Perfusi...

journal_title：Brain research

authors： Arai I,Shimazoe T,Shibata S,Inoue H,Yoshimatsu A,Watanabe S

更新日期：1996-08-12 00:00:00

abstract：:Excessive stimulation of neurons by glutamic acid initiates a destructive cascade of ion fluxes, cellular swelling, and death. Homeostatic mechanisms which rectify these disturbances depend largely upon transmembrane ion gradients maintained by Na+,K(+)-ATPase (NaP). We proposed that the neurotoxicity of glutamate is ...

journal_title：Brain research

authors： Brines ML,Robbins RJ

更新日期：1992-09-18 00:00:00

abstract：:Bulk-isolated human and bovine oligodendroglia, practically free from myelin, have been used in attempts to elicit an autoimmune response which has been compared with acute experimental allergic encephalomyelitis (EAE). For these experiments, a total of 20 Hartley guinea pigs, 33 Lewis rats and 16 rabbits have been st...

journal_title：Brain research

authors： Raine CS,Wiśniewski HM,Iqbal K,Grundkeiqbal I,Norton WT

更新日期：1977-01-21 00:00:00

abstract：:The cholinergic agonist pilocarpine injected intraperitoneally (ip) increases mean arterial pressure (MAP) and superior mesenteric (SM) vascular resistance and reduces submandibular/sublingual gland (SSG) vascular resistance. In the present study, we investigated the effects of electrolytic lesions of the anteroventra...

journal_title：Brain research

authors： Takakura AC,Moreira TS,De Luca LA Jr,Renzi A,Menani JV,Colombari E

更新日期：2005-09-07 00:00:00

abstract：:Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...

journal_title：Brain research

authors： Feng HJ,Yang L,Faingold CL

更新日期：2007-04-13 00:00:00

abstract：:The serotonin neurotoxin, 5,6-dihydroxytryptamine (5,6-DHT), was injected into the body cavity of snails. Changes induced in the central nervous system (CNS) by the neurotoxin were studied by morphological, electrophysiological and biochemical techniques for up to 90 days following injection. The neurotoxin induced a ...

journal_title：Brain research

authors： Hernádi L,Hiripi L,Vehovszky A,Kemenes G,Rózsa K

更新日期：1992-04-24 00:00:00

abstract：:We have studied the effects of prenatal protein malnutrition on development of the hippocampal and frontal cortical electroencephalographic (EEG) activity. Using power spectral analyses in rats of several age groups we found that protein malnutrition, instituted prenatally and continued postnatally, produces marked al...

journal_title：Brain research

authors： Morgane PJ,Austin K,Siok C,LaFrance R,Bronzino JD

更新日期：1985-10-01 00:00:00

abstract：:There is a large body of evidence indicating important interactions between the adenosine and opioid systems in regulating pain at both the spinal and supraspinal level. Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed and the animals show complete loss of analgesic responses to morphine...

journal_title：Brain research

authors： Bailey A,Matthes H,Kieffer B,Slowe S,Hourani SM,Kitchen I

更新日期：2002-07-05 00:00:00

abstract：:The development of afferent projections to the cerebellum was studied by making small (20 nl) injections of True blue into the cerebella of neonatal rats under general anaesthesia. Neurones in all main precerebellar nuclei were labelled even in rats less than one day old. With the exception of the disappearance of sma...

journal_title：Brain research

authors： Payne JN,Bower AJ

更新日期：1988-04-01 00:00:00

abstract：:The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of...

journal_title：Brain research

authors： Wen GY,Wisniewski HM,Kascsak RJ

更新日期：1999-06-19 00:00:00

abstract：:The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of ...

journal_title：Brain research

authors： Horn KM,Carey RG

更新日期：1987-07-21 00:00:00

abstract：:A systematic clinical neuroscience protocol is described for the use to examine the trigemino-cardiac reflex (TCR) response in humans. Target neurosurgical conditions are operations that require manipulations around the peripheral and central part of the trigeminal nerve and its branches, e.g. the cerebellopontine ang...

journal_title：Brain research

authors： Schaller BJ,Weigel D,Filis A,Buchfelder M

更新日期：2007-05-29 00:00:00

abstract：:Animal models of cerebral infarction are crucial to understanding the mechanisms of neuronal survival following ischemic brain injury and to the development of therapeutic interventions for victims of all types of stroke. Rodents have been used extensively in such research. One rodent model of stroke utilizes either p...

journal_title：Brain research

authors： Duckworth EA,Butler TL,De Mesquita D,Collier SN,Collier L,Pennypacker KR

更新日期：2005-04-25 00:00:00

abstract：:Inflammation is an important factor for hypoxia-ischemia (HI) brain injury. Interleukin (IL)-18 is a proinflammatory cytokine which may be a contributor to injury in the immature brain after HI. To investigate the effects of post-HI hypothermia on IL-18 in the developing brain, 7-day-old rats were subjected to left ca...

journal_title：Brain research

authors： Fukui O,Kinugasa Y,Fukuda A,Fukuda H,Tskitishvili E,Hayashi S,Song M,Kanagawa T,Hosono T,Shimoya K,Murata Y

更新日期：2006-11-22 00:00:00

abstract：:Unlike the basal ganglia input from the midline and intralaminar nuclei, the origin and prominence of striatal projections arising in the lateral thalamus varies considerably among mammals being most restricted in the opossum and monkey, most extensive in the rat. To get further insight into the evolution of thalamo-s...

journal_title：Brain research

authors： Künzle H

更新日期：2006-07-19 00:00:00

abstract：:To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...

journal_title：Brain research

authors： Appelt DM,Balin BJ

更新日期：1997-01-16 00:00:00

abstract：:Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. The use of [14C]5-HIA...

journal_title：Brain research

authors： Min-Chu L,Mackenna BR,Watt JA

更新日期：1981-03-23 00:00:00

abstract：:Many neurons release a variety of amino acids in response to depolarizing stimuli. Although some of these amino acids, namely, glutamate, aspartate, and gamma-aminobutyric acid (GABA), have been qualified as neurotransmitters, functional roles of the other amino acids including alanine remain obscure. We investigated ...

journal_title：Brain research

authors： Koga T,Kozaki S,Takahashi M

更新日期：2002-10-18 00:00:00

abstract：OBJECTIVE:The purpose of this study is to characterize functional connectivity changes in mild cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task conditions. METHOD:EEG signals were recorded under resting states (Eyes closed (EC) and Eyes open (EO)) and cognitive states (Mental Arithmetic...

journal_title：Brain research

authors： Das S,Puthankattil SD

更新日期：2020-05-15 00:00:00

abstract：:The distributions and inductions of Cu/Zn superoxide dismutase (SOD), neuronal and endothelial nitric oxide (NO) synthase (nNOS and eNOS), and nitrotyrosine (NT) were immunohistochemically examined in rabbit spinal cords after 5 and 15 min of transient ischemia. The neurons in the anterior horns (AH) were selectively ...

journal_title：Brain research

authors： Watanabe M,Sakurai M,Abe K,Aoki M,Sadahiro M,Tabayashi K,Okamoto K,Shoji M,Itoyama Y

更新日期：1996-09-02 00:00:00

abstract：:Increasing evidence have shown that beta-amyloid (Abeta) induced hyperphosphorylation of tau, which eventually resulted in the disruption of microtubule (MT) integrity. Cyclin-dependent kinase 5 (CDK5) and its activator p35 are required for neurite outgrowth. The cleavage of p35 to p25, mediated by calpain and calcium...

journal_title：Brain research

authors： Chen X,Huang T,Zhang J,Song J,Chen L,Zhu Y

更新日期：2008-03-20 00:00:00

abstract：:Parkinson's Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive imp...

journal_title：Brain research

authors： Marshall CA,King KM,Kortagere S

更新日期：2019-01-01 00:00:00

abstract：:Increased neurogenesis by promoting proliferation of neural precursor cells in the adult dentate gyrus might be beneficial for the treatment of psychiatric disorders. Results demonstrate that bFGF is necessary for the proliferation of neural precursor cells and that the glycogen synthase kinase-3β (GSK-3β) and β-caten...

journal_title：Brain research

authors： Boku S,Nakagawa S,Toda H,Kato A,Takamura N,Omiya Y,Inoue T,Koyama T

更新日期：2013-01-25 00:00:00

abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...

journal_title：Brain research

authors： Ventura AL,Paes de Carvalho R

更新日期：1987-09-01 00:00:00

abstract：:Sex steroid hormones regulate various neural functions that control vertebrate sociosexual behavior. A number of sex steroids can be synthesized de novo in the brain, including estrogens by the enzyme aromatase. Aromatase, the neuropeptides arginine vasotocin/vasopressin, and the monoamine neurotransmitter dopamine ha...

journal_title：Brain research

authors： Marsh KE,Creutz LM,Hawkins MB,Godwin J

更新日期：2006-12-18 00:00:00

abstract：:In the present studies, we have evaluated the effects of N-[4-(2-¿[(3-Chlorophenyl)methyl]amino¿ethyl)phenyl]-2-thiophenecarbo ximidamide dihydrochloride (ARL 17477) on recombinant human neuronal NOS (nNOS) and endothelial NOS (eNOS). We then carried out pharmacokinetic studies and measured cortical nitric oxide synth...

journal_title：Brain research

authors： O'Neill MJ,Murray TK,McCarty DR,Hicks CA,Dell CP,Patrick KE,Ward MA,Osborne DJ,Wiernicki TR,Roman CR,Lodge D,Fleisch JH,Singh J

更新日期：2000-07-21 00:00:00