Abstract：
:We studied the effect of the cortical projection from the basal forebrain on the cerebral cortical metabolism using positron emission tomography (PET) with [(18)F] fluorodeoxyglucose. Unilateral damage of the nucleus basalis magnocellularis (NBM) did not cause a permanent reduction of cortical metabolism: recovery was observed 4 weeks after the operation. Destruction of the contralateral side after recovery from unilateral damage produced persistent bilateral suppression of glucose metabolism, with partial recovery. We speculate that recovery from the unilateral NBM lesions is partly ascribable to the cholinergic projection from the contralateral NBM, and partly due to non-cholinergic systems, and conclude that bilateral damage might be responsible for persistent cortical glucose metabolism suppression.
journal_name
Brain Resjournal_title
Brain researchauthors
Katsumi Y,Hanakawa T,Fukuyama H,Hayashi T,Nagahama Y,Yamauchi H,Ouchi Y,Tsukada H,Shibasaki Hdoi
10.1016/s0006-8993(99)01530-9subject
Has Abstractpub_date
1999-08-07 00:00:00pages
75-82issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01530-9journal_volume
837pub_type
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