Abstract：
:Non-specific convulsive behavior induced by intrathecal (IT) morphine microinjection appears to be tonically modulated by centrifugal pathways originating within the brain since the frequency of IT morphine-induced hindlimb seizures and myoclonic twitches are both increased following spinal transection. These effects on convulsant activity are dissociable by selective neural lesions. Bilateral dorsolateral funiculus lesions potentiate seizure activity whereas ventral funiculus lesions and, to a lesser extent, interruption of cerebral cortical influences enhance myoclonic twitch activity. These initial studies indicate that distinct supraspinal centers differentially modulate myoclonic and seizure activity and suggest that an understanding of these systems may have clinical implications for the control of convulsant activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Watkins LR,Frenk H,Miller J,Mayer DJdoi
10.1016/0006-8993(84)90156-2subject
Has Abstractpub_date
1984-09-24 00:00:00pages
337-45issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)90156-2journal_volume
310pub_type
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