Abstract：
:The origin of neuronal perikarya which project to the external zone of the median eminence (the tuberoinfundibular neuronal system) was determined in the rat after injection or diffusion of wheat germ agglutinin (WGA) into the median eminence. The retrogradely transported lectin was detected in neurons using an immunohistochemical method based on the peroxidase-antiperoxidase technique. Immunoreactive cell bodies were found both in hypothalamic and extrahypothalamic regions. Within the hypothalamus, the majority of peroxidase-positive cells were present in the dorsomedial and basolateral portions of the arcuate nucleus, regions of the periventricular nucleus, and the preoptic region, particularly at the level of the organum vasculosum of the lamina terminalis (OVLT). Within the extrahypothalamic regions, WGA-positive perikarya were found in the diagonal band of Broca, the region of the medical septum and the brainstem. Only rare cells were labeled in the ventromedial nucleus of the hypothalamus and no cells were labeled in any region of the amygdala. These data demonstrate that neurons with afferent projections to the median eminence are more widely distributed in the rat brain than previously recognized and therefore, that the concept of the tuberoinfundibular neuronal system must be expanded.
journal_name
Brain Resjournal_title
Brain researchauthors
Lechan RM,Nestler JL,Jacobson Sdoi
10.1016/0006-8993(82)90334-1subject
Has Abstractpub_date
1982-08-05 00:00:00pages
1-15issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(82)90334-1journal_volume
245pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In order to determine the origin of the catecholamine innervation of the rat piriform cortex (PC), we combined retrograde transport of the B subunit of the cholera toxin (CTb) with tyrosine hydroxylase (TH) immunohistochemistry. A substantial number of CTb retrogradely labeled cells was found in the parabrachial pigme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01279-6
更新日期：1996-02-26 00:00:00
abstract：:The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariect...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.024
更新日期：2004-09-17 00:00:00
abstract：:Striatal kainic acid (KA) lesions induce behavioral and biochemical deficits which resemble symptoms encountered in patients suffering from Huntington's disease. In rats with KA lesions, fetal striatal transplants have shown to reverse the pervasive nocturnal hyperactivity induced by the lesion. In the present study 4...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91313-3
更新日期：1988-04-12 00:00:00
abstract：:A monospecific antibody against tyrosine hydroxylase (TH), purified from a transplantable rat pheochromocytoma, was produced in rabbits. Immunohistochemical techniques were employed in order to determine if a relationship exists between the subcellular distribution of TH and the level of activation of the enzyme in th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90158-x
更新日期：1981-03-30 00:00:00
abstract：:The present study examined the role of the sympathetic nervous system as a mediator of the message from the CNS to the kidneys to stimulate the secretion of renin. Two procedures that increase the secretion of renin were tested: administration of the serotonin releaser fenfluramine, which increases renin release witho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00891-s
更新日期：1995-11-06 00:00:00
abstract：:Growth cones integrate a remarkably complex concert of chemical cues to guide axons to their appropriate destinations. Recent work suggests that integrins contribute to axon guidance by interacting with a wide range of extracellular molecules including axon guidance molecules, by mechanisms that are not fully understo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.045
更新日期：2013-11-06 00:00:00
abstract：:Manganese (Mn) is an essential trace element required for ubiquitous enzymatic reactions. Chronic overexposure to this metal may, however, promote potent neurotoxic effects. The mechanism of Mn toxicity is not well established, but several studies indicate that oxidative stress and mitochondria play major roles in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.125
更新日期：2008-10-21 00:00:00
abstract：:Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01500-0
更新日期：1996-04-22 00:00:00
abstract：:We examined the effect of gangliosides on Schwann cell cultures isolated from neonatal rat sciatic nerves. Addition of gangliosides (GM1, GM3, and ganglioside mixture) at concentrations between 0.25 and 2 mg/ml significantly diminished both the baseline rate of proliferation of the Schwann cells and their response to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90442-8
更新日期：1988-12-06 00:00:00
abstract：:Mammalian transglutaminases (TGs) catalyze the irreversible post-translational modifications of proteins, the most prominent of which is the calcium-dependent formation of covalent acyl transfers between the γ-carboxamide group of glutamine and the ε-amino-group of lysine (GGEL-linkage). In the central nervous system,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.11.027
更新日期：2016-01-15 00:00:00
abstract：:Deposition of beta-amyloid (A beta) is a characteristic feature of the pathology of Alzheimer's disease (AD). Since glucose metabolism and the consequential ATP production are depressed in the temporal and parietal regions of the cortex in patients with AD, we designed the present study to investigate the possible rol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00827-5
更新日期：1997-10-24 00:00:00
abstract：:We investigated the effect of Cerebrospinal Fluid (CSF) from sporadic Amyotrophic Lateral Sclerosis patients (SALS-CSF) on motor neuron-like cells to delineate the pathomechanism of SALS. Exposure of NSC-34 cells to SALS-CSF caused lower viability, reduction in differentiation and enhanced lactate dehydrogenase activi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.041
更新日期：2009-03-31 00:00:00
abstract：:Immunocytochemical and immunoblotting technique have been used to characterize the antigens recognized by two monoclonal antibodies (MAbs C6 and D5) produced against dissociated cells from punches of neonatal supraoptic (SON) and paraventricular (PVN) hypothalamic nuclei of the rat. Peroxidase immunocytochemistry reve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91281-5
更新日期：1991-04-05 00:00:00
abstract：:Motor cortex stimulation (MCS) is a promising clinical procedure to help alleviate chronic pain. Animal models demonstrated that MCS is effective in lessening nocifensive behaviors. The present study explored the effects of MCS on cortical somatosensory evoked potentials (SEPs) recorded at the primary somatosensory co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.027
更新日期：2012-06-29 00:00:00
abstract：:Routine cell stains disclose abnormal, usually single, nests of ectopic neurons in neocortical layer I of New Zealand Black (NZB) and BXSB autoimmune mice. We have suggested that these anomalies represent only the most visible part of more widespread cortical disorganization. In an attempt to determine the true magnit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90828-y
更新日期：1990-10-08 00:00:00
abstract：:Sex hormone binding globulin (SHBG) is found in the brain and acts directly on plasma membrane-associated receptors in the prostate gland. Infusing SHBG into the medial preoptic area or medial basal hypothalamus of female rats increases their female sexual receptivity. SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E pl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02569-5
更新日期：2000-08-18 00:00:00
abstract：:Sleep-suppressive activity of prostaglandin synthesis inhibitors, diclofenac sodium (DF) and indomethacin (IM), was examined in unrestrained male rats. An intraperitoneal injection of 5 mg/kg IM, or an oral administration of 5 mg/kg DF and 10 mg/kg IM at an early phase of the light period transiently decreased slow wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90173-4
更新日期：1988-06-21 00:00:00
abstract：:The organization of the wing component of the dorsal column-medial lemniscal pathway, and somatosensory projections from the thalamus to the Wulst, are described for an oscine member of the major group of birds, the Passeriformes. Wing primary afferents terminate throughout the cervical spinal cord, but between the br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00253-9
更新日期：1997-06-06 00:00:00
abstract：:Neuropeptide Y (NPY) has been detected immunocytochemically in cerebral cortex and subcortical white matter of the primate frontal, parietal, temporal, and occipital lobes. Because little is known about NPY in the primate insular lobe and because peptides play an important role in normal neuronal functioning and alter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91245-n
更新日期：1993-02-19 00:00:00
abstract：:The effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Cell suspensions of ventral mesencephalon from 14-15-day-old rat fetuses (ri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90174-4
更新日期：1986-01-01 00:00:00
abstract：:Two distinct serotonin receptors in mammalian brain are labeled respectively with [3H]serotonin (5-HT1) and [3H]spiperone (5-HT2). In general agonists display highest affinities for 5-HT1 while antagonists prefer 5-HT2 sites. To conduct regional studies of 5-HT receptors, we estimated 5-HT2 sites with [3H]spiperone, u...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90562-x
更新日期：1981-03-16 00:00:00
abstract：:Peripheral nerve fascicles are deliberately impaled during microneurography experiments. We have assessed conduction block under these circumstances. First we recorded compound action potentials (CAP) in the sural nerve following stimulation of the sciatic nerve. The insertion of injection and microneurography electro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91538-4
更新日期：1993-12-24 00:00:00
abstract：:The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90244-7
更新日期：1987-09-08 00:00:00
abstract：:Activity of second-order relay neurons in the nucleus tractus solitarius (NTS) is regulated by peripheral and intrinsic synaptic inputs, and modulation of those inputs by metabotropic glutamate receptors (mGluRs) has been proposed. This study investigated effects of mGluR activation on glutamatergic transmission in th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.04.031
更新日期：2014-09-18 00:00:00
abstract：:Dopamine-releasing protein (DARP) is a novel factor involved in the function and development of catecholaminergic systems. To test whether a peptide synthesized from the N-terminus of DARP (DARP-36aa) ameliorates deficits in nigrostriatal dopamine, rats were unilaterally lesioned with MPP+, 1 day before administration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90291-7
更新日期：1994-12-12 00:00:00
abstract：:Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. However, there has been no report characterizing the neuroprotective action and therapeutic time window of tacrolimus systematically using different types of stroke models and extended observation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04151-3
更新日期：2003-03-07 00:00:00
abstract：:This experiment was performed in order to examine several of the underlying mechanisms by which the septal area and adjacent regions regulate quiet biting attack behavior elicited from electrical stimulation of the hypothalamus in the cat. The results clearly indicate that stimulation of the septal area and anterior c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90147-1
更新日期：1984-09-24 00:00:00
abstract：:The effects of 17 beta-estradiol benzoate (EB), ethynodioldiacetate and ovine prolactin on dopamine (DA) turnover have been studied. As an index for a change in turnover, differences in DA depletion following tyrosine hydroxylase inhibition with alpha-methyl-tyrosine methylester were observed. DA was measured by means...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90728-x
更新日期：1978-06-16 00:00:00
abstract：:Ongoing electrical activity was recorded from the axons of neurosecretory cells from the brain of 5th instar Rhodnius prolixus throughout the moulting cycle. Dramatic changes in both the frequency and pattern of electrical activity occur at specific times during the cycle, enabling the timing of release of neurohormon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90314-5
更新日期：1980-06-02 00:00:00
abstract：:The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueductal grey (PAG) modulates pain. This study characterised PPAR signalling...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.022
更新日期：2017-02-15 00:00:00
