Abstract:
:The termination of a pathway recently discovered in monkey, from the external cuneate nucleus (ECN) to the thalamus, has been investigated with the degeneration method. A previous HRP study showed that the projection is crossed. The ECN fibers terminate a wedge-shaped zone located dorsally in the rostral half of the contralateral nucleus ventralis posterolateralis (VPL). This zone occupies the dorsolateral corner of the forelimb division of the VPL. The main cuneate nucleus also projects to this zone, most of which has the cytoarchitectonic characteristics of Olszewski's VPLc24. The ECN pathway may be phylogenetically recent, and it may be a direct route for proprioceptive information to the cerebral cortex.
journal_name
Brain Resjournal_title
Brain researchauthors
Boivie J,Boman Kdoi
10.1016/0006-8993(81)90856-8subject
Has Abstractpub_date
1981-11-16 00:00:00pages
235-46issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90856-8journal_volume
224pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Extracellular single-unit activity was recorded from neurons of the internal and external pallidal segments, and from 'border cells' at the periphery of the segments, in 3 waking cynomolgus monkeys during electrical stimulation of 3 sites bilaterally in the striatum: one in the caudate nucleus and two in the putamen. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90394-6
更新日期:1989-09-25 00:00:00
abstract::Recent studies suggest that apolipoprotein E (apoE) might play a neurotrophic function in the central nervous system and that altered functioning of this molecule could result in neurodegeneration. The main objective of this study was to determine if neurodegenerative and cognitive alterations in apoE-deficient mice a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01420-5
更新日期:1997-03-21 00:00:00
abstract::The phenomenon of unidirectional non-cross tolerance (UNCT) to etorphine was observed in adult male rats tolerant to morphine. Using a morphine pellet (four 75 mg morphine pellets) implantation protocol, a 10-fold increase in the analgesic ED50 value, obtained by tail-flick assay, was observed for morphine sulfate, wi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91502-1
更新日期:1985-02-18 00:00:00
abstract::Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.10.002
更新日期:2019-02-01 00:00:00
abstract::Although Rolling mouse Nagoya (RMN) has been considered to demonstrate cerebellar dysfunction, our previous metabolic and electrophysiological studies also revealed a dysfunction of the basal ganglia, with the presumable primary site of dysfunction being the striatum. In the present study, we investigated the neuroche...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01577-9
更新日期:1996-04-01 00:00:00
abstract::The importance of Na+/Ca2+ exchangers in the regulation of the physiological and pathological functions of the nervous system has been widely recognized. In this study, we used primary cultured E14.5 cortical neurons as a model system to study the possible roles of the reverse mode Na+/Ca2+ exchange activity in neurot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.042
更新日期:2008-03-27 00:00:00
abstract::Corticotropin-releasing factor (CRF) in the brain plays an important role in regulations of physiological and behavioral processes, yet CRF distribution in tree shrew brain has not been thoroughly and systematically reported. Here we examined the distribution of CRF immunoreactivity in the brain of tree shrews (Tupaia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.06.004
更新日期:2015-08-27 00:00:00
abstract::Corticosteroids exert important effects on brain function via glucocorticoid (GRs) and mineralocorticoid receptors (MRs) by inducing receptor translocation to the nucleus, where the receptor-ligand complexes modulate transcription of target genes. Based on studies describing uneven receptor expression patterns, region...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.048
更新日期:2009-01-16 00:00:00
abstract::We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.097
更新日期:2005-04-25 00:00:00
abstract::Fetal exposure to dexamethasone (DEX) alters brain plasticity and cognitive functions during adulthood in a sex-dependent manner. The mechanisms underlying such long-lasting sex-dependent change of prenatal DEX is not well understood. The p73 gene plays an important role in brain development. It encodes for two protei...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.11.030
更新日期:2019-03-15 00:00:00
abstract::Nociceptin/orphanin FQ is an endogenous neuropeptide that plays important roles in several physiological functions including pain, anxiety, locomotion, learning, and memory. We previously reported that low doses of nociceptin improved the scopolamine-induced impairment of learning and memory in the passive avoidance t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.008
更新日期:2008-02-21 00:00:00
abstract::The opioid peptides Leu-enkephalin, Met-enkephalin and D-Ala2-Met-enkephalinamide were injected at various concentrations into the neocortex and hippocampus of rats to examine their effects on EEG activity and DC potentials. All three compounds were found to elicit spreading depression (SD) in both structures. Higher ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90897-0
更新日期:1981-04-06 00:00:00
abstract::We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91575-6
更新日期:1985-05-06 00:00:00
abstract::Cerebellum is involved in the motion coordination and working memory, to which spike programming at Purkinje neurons are essential. The development of Purkinje neurons in the embryonic stage has been well studied. However, it is not clear about the maturation of their intrinsic property related to spike programming du...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.092
更新日期:2006-06-30 00:00:00
abstract::The rostral projection of A delta and C primary afferents in Lissauer's tract (LT) was studied by assessing how far, rostrally, axons entering at a given level could be activated by electrical stimulation. Sural A delta primary afferents in LT exhibited a rostral projection at least as far as the L3/L4 border, 4 segme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90617-7
更新日期:1986-12-03 00:00:00
abstract::In the present study, the effects of intra-central amygdala (CeA) injection of dopamine D1 receptor agonist and antagonist on morphine-induced conditioned place preference (CPP) were investigated in male Wistar rats. Our data showed that subcutaneous (s.c.) injection of morphine sulphate (0.5-10 mg/kg) significantly i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04201-4
更新日期:2003-03-07 00:00:00
abstract::Intracellular and extracellular recordings from CA3 hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-D-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (D-2-amino-5-phosphonova...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90642-7
更新日期:1988-09-06 00:00:00
abstract::Studies using phorbol esters imply that hippocampal Ca2+ channels are regulated by protein kinase C (PKC); however concerns have been raised because in some circumstances phorbol esters have non-specific effects on ion channels. We have tested the hypothesis that PKC modulates Ca2+ channel activity in hippocampal neur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91502-6
更新日期:1992-11-27 00:00:00
abstract::Olfactory bulbectomy (OBX) in rodents induces neurochemical and behavioral changes similar to those observed in individuals with depressive disorders. Our previous study suggested that OBX alters dopaminergic function in the striatum of mice; however, the effects on dopaminergic function in the hypothalamus is unknown...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147015
更新日期:2020-11-01 00:00:00
abstract::The pyrithiamine-treated rats produced by our method histopathologically exhibited the edematous lesion not only around the third ventricle and at the tegmentum of pons, as expected, but also in the cerebral cortex. These animals were, therefore, used in a biochemical study of the cerebral cortex, in particular, gluco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91399-6
更新日期:1988-02-16 00:00:00
abstract::Prominent cellular responses to axonal interruption include enhanced synthesis of RNA and protein in the neuronal perikaryon, and proliferation of reactive Schwann cells. Since morphine has been shown to significantly depress cellular metabolism, we examined its effect on these and other reparative responses underlyin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)91010-2
更新日期:1979-10-19 00:00:00
abstract::The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the froze...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90869-0
更新日期:1980-08-11 00:00:00
abstract::Adequate grip force modulation is critical to manual dexterity and often impaired in hemiparetic stroke patients. Previous studies in hemiparetic patients suggest that aspects of grip force control may be differently affected by the lesion. We developed a visuomotor power grip force-tracking task allowing quantificati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.03.007
更新日期:2012-05-03 00:00:00
abstract::We studied whether K+, a potent cerebrovasodilator released by active neurons, participates in the increase in cortical cerebral blood flow (CBF) elicited by stimulation of the cerebellar fastigial nucleus (FN). Rats were anesthetized by continuous administration of halothane (1-3%), paralyzed and artificially ventila...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91544-b
更新日期:1991-11-01 00:00:00
abstract::Spinally-projecting A5 neurons were studied with anatomical and electrophysiological techniques in the rat. A detailed study of the number and distribution of spinally-projecting catecholaminergic (CA) and non-catecholaminergic neurons present in a defined area of ventrolateral pontine reticular formation was performe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90206-3
更新日期:1984-06-11 00:00:00
abstract::Focal adhesion kinase (FAK) and proline-rich tyrosine kinase (PYK2) are two related non-receptor tyrosine kinases which are thought to play a role in transducing extracellular matrix (ECM)-derived survival signals into cells. The functions of FAK and PYK2 are linked to autophosphorylation of their specific tyrosine re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.022
更新日期:2015-05-05 00:00:00
abstract::From previous inverse dynamic analyses of human leg extensions, it was hypothesized that the underlying processes for the activation of mono- and biarticular muscles are different; the mono-articular muscles being activated when they shortened, whereas the biarticular muscles appeared responsible for the control of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01327-3
更新日期:1997-03-21 00:00:00
abstract::Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.023
更新日期:2018-08-01 00:00:00
abstract::The hetero-bifunctional nitroimidazole radiosensitizer CI-1010, R-alpha-[[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazole-1-ethanol monohydrobromide, causes selective irreversible apoptotic loss of retinal photoreceptor cells in vivo. The human neuroblastoma cell line, SH-SY5Y, was used as a neuronotypic model of CI...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03838-6
更新日期:2003-02-14 00:00:00
abstract::The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90439-3
更新日期:1989-06-19 00:00:00