Abstract：
:Treatment with the short-acting benzodiazepine, triazolam (Tz), 6 h before activity onset (CT 6) induces large phase advances in the circadian rhythm of locomotor activity in golden hamsters free-running in constant lighting conditions. These phase shifts are associated with acute increases in locomotor activity. The acute increases in activity appear to be necessary for induction of phase shifts in the activity rhythm by Tz, since suppression of this activity by restraining the animal blocks the phase shifts normally induced by Tz. Furthermore, other stimuli which induce an acute increase in locomotor activity phase shift the circadian clock in a similar manner as does Tz. Since increased locomotor activity is associated with a rise in body temperature in mammals, and changes in temperature have been associated with changes in circadian rhythms, this study was designed to determine whether the phase-shifting effect of Tz on the circadian clock could be mediated by the change in body temperature resulting from the induced acute increase in locomotor activity. Hamsters free-running in constant light (LL) were implanted with Mini-Mitter biotelemetry devices and either injected with Tz at CT 6, injected with Tz at CT 6 and restrained for the next 6 h, or restrained for 6 h beginning at CT 6. Treatment with Tz resulted in large phase advances in the activity rhythm, while the other two treatments did not induce phase advances. Mean body temperature increased over control levels for all 3 groups during most of the 6 h following the beginning of treatment, and there were no significant differences in body temperature changes between any pairs of groups.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Wickland C,Turek FWdoi
10.1016/0006-8993(91)91208-isubject
Has Abstractpub_date
1991-09-27 00:00:00pages
12-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91208-Ijournal_volume
560pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The intracerebroventricular injection (1 microgram) of murine corticotropin-releasing factor (r-CRF) to rats after 72 h of sleep deprivation markedly postponed the sleep onset, reduced slow wave sleep and prolonged the duration of paradoxical sleep (PS) episodes. Moreover, CRF is-to our knowledge-the first compound to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90614-h
更新日期：1990-05-07 00:00:00
abstract：:The dominant pacemaker of the mammalian circadian clock, located in the suprachiasmatic nucleus (SCN), is of special interest for many pharmacological, physiological and immunohistological studies on angiotensins and their receptors. Based on its role in the circadian modulation of blood pressure and vasopressin relea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.085
更新日期：2004-05-22 00:00:00
abstract：:Serotonin transporter (5-HTT) mRNA and 5-HTT sites were measured 3 days after treatment with p-chlorophenylalanine, a tryptophan hydroxylase inhibitor. While 5-HTT mRNA levels decreased (P < 0.001) in the dorsal raphe nucleus, 5-HTT binding sites remained unchanged, suggesting that an acute depletion of 5-HT may induc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00539-3
更新日期：1995-08-07 00:00:00
abstract：:Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90541-g
更新日期：1992-04-10 00:00:00
abstract：:Previous work has shown a relatively high turnover of adrenaline in the mediobasal hypothalamus during the critical period (15.00-17.00 h) of the proestrous rat. We now report that this high level of adrenergic activity can be detected in the median eminence (turnover rate 1.62 +/- 0.36 pg/micrograms protein/h) rather...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90307-x
更新日期：1984-12-10 00:00:00
abstract：:The epileptogenic properties of the mast cell degranulating peptide (MCD) have been investigated in the CA3 region of the hippocampal slice preparation. Brief (3-5 min) bath application of MCD (0.5-2 microM) to CA3 hippocampal neurones produced an enhancement of the spontaneous synaptic activity and the appearance of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91077-3
更新日期：1988-03-29 00:00:00
abstract：:Motoneuron phenotype in the spinal cord is regulated by an intrinsic genetic program, extrinsic environmental signals and target-derived molecules. Axonal lesions trigger a phenotype switch to foster repair phenomena and axonal re-growth. We have investigated the influence of the long-term treatment with thyroid hormo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03266-8
更新日期：2002-01-25 00:00:00
abstract：:Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.10.011
更新日期：2016-06-15 00:00:00
abstract：:Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with the adenosine A1 receptor. There is now also evidence for electrophysiological effects mediated by adenosine receptors other than the A1 type, possibly A2 receptors. A1 and A2 receptor-induced changes in the electrical proper...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91160-3
更新日期：1991-04-12 00:00:00
abstract：:The diagonal band of Broca (dbB) is involved in central cardiovascular control. In the present study we compared the effects of microinjections of L-glutamate into the dbB of unanesthetized rats with those observed after the injection of L-glutamate into the same area in urethane-anesthetized rats. The microinjection ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03769-1
更新日期：2003-01-10 00:00:00
abstract：:This study compared patterns of Fos expression within the suprachiasmatic nucleus (SCN), the region immediately dorsal to the SCN (the lower subparaventricular zone, LSPV), and the supraoptic nucleus (SON) of grass rats (Arvicanthis niloticus) and lab rats (Rattus norvegicus). Among grass rats we also compared individ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02205-3
更新日期：2001-04-27 00:00:00
abstract：:The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90452-0
更新日期：1988-12-06 00:00:00
abstract：:A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03756-3
更新日期：2003-01-03 00:00:00
abstract：:Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147235
更新日期：2021-02-15 00:00:00
abstract：:Anticipation of an unavoidable painful stimulation, i.e. anticipation stress, induces analgesia. This analgesia may result from activation of the endogenous opioid peptide system as it is blocked by naloxone. The present paper characterizes the anticipation stress further by following the kinetics of the analgesia ris...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91674-0
更新日期：1989-12-04 00:00:00
abstract：:Much evidence suggests that the neuropeptide cholecystokinin (CCK) functions as a neurotransmitter or neuromodulator in the central nervous system. The CCKa receptor subtype in the nucleus accumbens has been demonstrated to potentiate the behavioral and neurophysiological effects of dopamine. Since the mesolimbic dopa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00918-g
更新日期：1995-11-20 00:00:00
abstract：:The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.08.006
更新日期：2004-10-29 00:00:00
abstract：:Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02417-8
更新日期：2000-02-28 00:00:00
abstract：:Chick embryos ranging in age from 4.0 to 18 days of incubation and 1-2-day-old hatchlings received injections of HRP solutions directly into the leg musculature. After survival periods of from 5 to 25 h motoneurons and cells in the spinal sensory ganglia were found to be stained with the HRP reaction product. It was f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90007-4
更新日期：1975-11-14 00:00:00
abstract：:Elevated levels of oxidative stress or decreased antioxidant defense mechanisms may underlie the regionally increased oxidative damage to brain observed in many neurodegenerative disorders. Phase I detoxification pathways for reactive aldehydes generated from lipid peroxidation include aldehyde dehydrogenases, alcohol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02897-9
更新日期：2001-10-19 00:00:00
abstract：:Intracellular recordings and labelings with horseradish peroxidase (HRP) of expiratory (E) neurons were performed in decerebrate, paralyzed, and ventilated rats. A total of 37 neurons were recorded, from which 4 cells and 1 axon were labeled. They were located in two regions of the ventrolateral medulla. One was in th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90687-5
更新日期：1992-04-03 00:00:00
abstract：:Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-09-23 00:00:00
abstract：:In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors. However, the in vivo biological significance of that truncation has not been explored. In an attempt to elucidate if GSK3 truncation has a pathophysiological relevance, we h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.016
更新日期：2015-06-22 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution of these isoforms to GABA synthesis flux (V(GAD)) is not known quantitatively. In the present study we compared V(GAD) in cortex of control and vigabatrin-treate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02778-0
更新日期：2001-09-28 00:00:00
abstract：:Horseradish peroxidase (HRP, 30% solution, 0.1-0.3 mul, 72 h) was injected unilaterally into the basal striatum (STR) and the dorsal ventricular ridge (DVR) of adult turtles (Chrysemys picta) in order to demonstrate the cells of origin of some afferents to these telencephalic structures. After selective STR injection,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90161-x
更新日期：1976-05-21 00:00:00
abstract：:The primary mechanism of action of bupropion, a smoking cessation drug, is commonly believed to involve the dopaminergic system although evidence exists that bupropion also has effects at nicotinic acetylcholine receptors (nAChRs). This study evaluated the disruptive effects of nicotine on response rates in the presen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.110
更新日期：2006-10-30 00:00:00
abstract：:Nodes of Ranvier in the central nervous system in mammals are characterized by the presence of perinodal astrocytic processes. This study examines the association between processes of radial glia and the axolemma at nodes of Ranvier in the spinal cord of the mature axolotl, an animal in which radial glia represent a l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90595-m
更新日期：1991-05-17 00:00:00
abstract：:Neurite formation in neurones isolated from adult molluscs in culture has been shown to depend on the total content of Ca in the cells, intracellular Ca2+ concentration, intracellular acid-alkaline balance, extracellular pH, and the capacity and composition of buffers. The neurones with a low total Ca content prior to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90546-2
更新日期：1983-10-03 00:00:00
abstract：:The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreacti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91583-0
更新日期：1994-08-15 00:00:00
abstract：:We previously reported that PC12h cells are killed by a high oxygen atmosphere. In this study, we further characterized this oxygen-induced cell death and found apoptotic features, as follows. Firstly, chromatin condensation was observed in cells cultured in a 50% O2 atmosphere. Secondly, cycloheximide and cordycepin,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00542-2
更新日期：1996-09-16 00:00:00
