Abstract：
:The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreactivity (CRF-LI) by RIA. CRF-LI secretion and content were also dose-dependently increased by forskolin. In addition, cell extracts were applied to a C18 Vydac column and peak CRF-LI from the collected fractions was shown to coincide in time of elution with peak immunoreactivity seen with oxidized synthetic CRF standard. Thus, in containing the CRF peptide, the BE (2)-M17 cells are useful models for further study of CRF cellular and genetic regulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Kasckow JW,Parkes DG,Owens MJ,Stipetic MD,Han JH,Nemeroff CB,Vale WWdoi
10.1016/0006-8993(94)91583-0subject
Has Abstractpub_date
1994-08-15 00:00:00pages
159-62issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)91583-0journal_volume
654pub_type
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