Abstract：
:A major effect of volatile anesthetics is to reduce excitatory synaptic transmission. In the present study the stimulated release of glutamate under the influence of increasing concentrations of isoflurane was studied in vitro by utilizing hippocampal slices from Wistar rats. Ca(2+)-dependent release was calculated by subtracting stimulated release with blocked synaptic transmission (50 mM K+, 0 mM Ca2+ and 4 mM Mg2+) from total evoked release (50 mM K+, 2 mM Ca2+ and 1 mM Mg2+). Isoflurane 0.5, 1.5 and 3% reduced Ca(2+)-dependent release of glutamate to 69, 58 and 49%, respectively (P < 0.05 for all related to control). These results are in agreement with the possibility of reduced release of transmitter as a mechanism of action of volatile anesthetics.
journal_name
Brain Resjournal_title
Brain researchauthors
Larsen M,Grøndahl TO,Haugstad TS,Langmoen IAdoi
10.1016/0006-8993(94)91282-3subject
Has Abstractpub_date
1994-11-14 00:00:00pages
335-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91282-3journal_volume
663pub_type
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