Abstract：
:We examined the effect of prostaglandin (PG)E2 on the sleep-wake activity and on body temperature by microinjecting PGE2 into the preoptic area of rats that had been chronically implanted with guide cannulae and electrodes for the recordings of electroencephalogram and electromyogram. PGE2 at doses of 2.5 X 10(-13), 2.5 X 10(-11), and 2.5 X 10(-9) mol reduced the time of slow wave sleep (SWS) to 75%, 61%, and 59% and that of paradoxical sleep (PS) to 73%, 50%, and 25% of the controls, respectively. The SWS and PS reductions were mainly due to the shortening of the SWS episode and the less frequent occurrence of PS episodes. The sleep reduction was accompanied by increased behavioral movement. The maximum increases of rectal temperature at doses of 2.5 X 10(-11) and 2.5 X 10(-9) mol of PGE2 were 1.3 degrees C and 2.7 degrees C, respectively. At a dose of 2.5 X 10(-13) mol of PGE2, the time of SWS and that of total sleep (sum of SWS and PS) decreased significantly, but the change in body temperature was negligible. This may imply that the effect of PGE2 on the sleep-wake activity is not caused by the hyperthermia produced by PGE2. Injections of PGE2 at a dose of 2.5 X 10(-15) mol and saline control induced alteration in neither sleep-wake activity nor body temperature. PGD2 at a dose of 2.5 X 10(-9) mol slightly elevated the rectal temperature (0.5 degree C), but did not produce any change in the sleep-wake activity.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Matsumura H,Goh Y,Ueno R,Sakai T,Hayaishi Odoi
10.1016/0006-8993(88)90935-3subject
Has Abstractpub_date
1988-03-22 00:00:00pages
265-72issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90935-3journal_volume
444pub_type
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