Abstract：
:Ibotenic acid lesions of the vertical limb of the diagonal band of Broca (VDB) in marmosets produced significant depletions in choline acetyltransferase (ChAT) activity and a decrease in acetylcholinesterase (AChE) staining in the hippocampal formation and entorhinal cortex (to which the cholinergic neurones of the VDB project) but not in the neocortex or amygdala. Marmosets with VDB lesions were impaired on acquisition (but not retention) of repeated trial visuospatial tasks. This impairment was ameliorated by pretreatment with the cholinergic agonist pilocarpine indicating (a) that the learning impairment was a consequence of damage to the cholinergic system and (b) that the cholinergic projections exert a modulatory or enabling function on the target areas which can be substituted by a non-impulse-dependent drug action. Unlike marmosets with lesions of the basal nucleus of Meynert (NBM), VDB-lesioned animals were not impaired on learning repeated trial object discrimination and showed no change in general behaviour although they did become hypothermic and mesomorphic. These results are consistent with the suggestion that the hippocampus (perhaps in conjunction with the entorhinal cortex) is concerned primarily with memory for responses but not memory for reward and that lesions of the cholinergic system produce impairments equivalent to the effects of ablation of the terminal areas.
journal_name
Brain Resjournal_title
Brain researchauthors
Ridley RM,Samson NA,Baker HF,Johnson JAdoi
10.1016/0006-8993(88)90348-4subject
Has Abstractpub_date
1988-07-19 00:00:00pages
71-87issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90348-4journal_volume
456pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In this study we compare the distribution of the phosphoprotein B-50 in two regions of immature and adult rat brain using affinity-purified antibodies to B-50. In the cerebellum of the 8-day-old rat we observed distinct patterns of distribution of B-50 immunoreactivity (BIR) in the premigratory zone and the developing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90747-x
更新日期：1986-06-11 00:00:00
abstract：:Stimulation of spinal serotonin (5-HT)(2A/2C) receptors has previously been reported to lead to either a pro-nociceptive or an anti-nociceptive response. Behavioral data have indicated that the pro-nociceptive effect is related to the release of substance P (SP). The aim of this in vivo microdialysis study was to inve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03216-5
更新日期：2003-10-10 00:00:00
abstract：:Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.040
更新日期：2018-11-01 00:00:00
abstract：:Growth hormone releasing factor (GRF) applied by iontophoresis, pressure, and in the perfusate, increased (14.81%) or decreased (45.92%) the firing of paraventricular neurons extracellularly recorded from guinea-pig hypothalamic slices. Effects were similar whatever the mode of application and were elicited in the nan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90374-4
更新日期：1986-04-23 00:00:00
abstract：:By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distributio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90981-z
更新日期：1991-05-03 00:00:00
abstract：:A short-acting non-barbiturate intravenous general anaesthetic, etomidate, when administered i.v. lowered serum prolactin levels in the rat. The effect was evident at rest, after surgical stress or after injection of 5-hydroxytryptophan. Haloperidol-induced hyperprolactinaemia was not modified. Administered via the in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90306-2
更新日期：1983-07-25 00:00:00
abstract：:Experiments have been performed on pentobarbitone anesthetized or decerebrated rats. The nature of the synchronous rhythmical activity which occurs in the inferior olive following the electrophoretic or systemic administration of harmaline, harmine, dihydro-beta-erythroidine and various other compounds, is described. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90471-6
更新日期：1976-01-23 00:00:00
abstract：:The spiral ganglion accommodates the cell bodies of the acoustic nerve fibres connecting the hair cells to the central nervous system. As the ionic channels containing various voltage-gated K+ channel (Kv) subunits play pivotal roles in determining the functional properties and firing behaviour of the spiral ganglion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.072
更新日期：2008-05-19 00:00:00
abstract：:The melanocortins (MC) can affect interscapular brown adipose tissue (IBAT) thermogenesis via its sympathetic nervous system (SNS) innervation. We chose a site of high MC4-receptor (MC4-R) mRNA co-localization with SNS outflow neurons to IBAT, the subzona incerta (subZI) to test whether IBAT thermogenesis could be inc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.003
更新日期：2011-09-09 00:00:00
abstract：:In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the res...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91453-3
更新日期：1987-05-26 00:00:00
abstract：:Rat pinealocytes use L-glutamate as a modulator for melatonin synthesis. Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output. Although L-gluta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02102-2
更新日期：1999-12-11 00:00:00
abstract：:One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90068-8
更新日期：1983-02-01 00:00:00
abstract：:This work examines the age-related changes of the NO pathway in the central nervous system (CNS), analyzing nitric oxide synthase (NOS) isoform expression, the level of nitrotyrosine-modified proteins, and the NOS activity in the cerebral cortex, decorticated brain (basal ganglia, thalamus, hypothalamus, tegtum and te...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03575-8
更新日期：2002-11-29 00:00:00
abstract：:Physical exercise is likely to alter brain function and to afford neuroprotection in several neurological diseases. Although the favorable effects of physical exercise on traumatic brain injury (TBI) patients is well known, little information is available regarding the role of free radicals in the improvement induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.052
更新日期：2009-07-07 00:00:00
abstract：:Field potentials (FP) recorded from the surface of toad's optic tectum (OT) to electrical stimulation of the contralateral optic nerve (ON) show initial positive deflections P*, followed by negative wave N and positive wave P; the former result from axonal inputs, the latter two resemble excitatory and inhibitory post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01260-o
更新日期：1995-01-09 00:00:00
abstract：:In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-relat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02890-0
更新日期：2000-11-10 00:00:00
abstract：:Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.022
更新日期：2010-09-24 00:00:00
abstract：:Extracellular recordings were carried out in the primary visual cortex of behaving macaque monkeys. Neurons were activated by moving a visual stimulus across their receptive fields during periods of steady fixation and by moving their receptive fields (by visual tracking) across a motionless visual stimulus, taking ca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90406-2
更新日期：1984-05-28 00:00:00
abstract：:Calretinin-immunoreactive structures in the anterior olfactory nucleus of the rat were studied using a polyclonal antibody, which does not cross-react with the highly homologous calcium-binding protein calbindin-D28k, and the avidin-biotin-peroxidase technique. Calretinin-immunopositive neurons were found in all regio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00023-7
更新日期：1998-04-06 00:00:00
abstract：:This study aimed to identify sites and mechanisms of long-term plasticity following lower limb muscle training. Two groups performing either a postural stability maintenance training (SMT) or a ballistic ankle strength training (BST) were compared to a non-training group. The hypothesis was that practicing of a self-i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.048
更新日期：2007-11-07 00:00:00
abstract：:We have already demonstrated that, although exogenous gamma-aminobutyric acidA (GABAA) receptor agonist is capable of inhibiting the activity of luteinizing hormone releasing hormone (LHRH) pulse generator, the reduction in the endogenous GABAA receptor activity does not have a significant effect in ovariectomized rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90145-7
更新日期：1994-04-04 00:00:00
abstract：:30-Day-old male Wistar rats were tested for acquisition and retention of operant conditioned behavior after bilateral subicular lesions made either electrolytically or chemically (ibotenic acid). The acquisition of operant learning was carried out in lesioned rats by assessing the number of sessions required to learn ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01135-3
更新日期：1997-01-16 00:00:00
abstract：:Lifelong bilingualism is associated with the delayed diagnosis of dementia, suggesting bilingual experience is relevant to brain health in aging. While the effects of bilingualism on cognitive functions across the lifespan are well documented, less is known about the neural substrates underlying differential behaviour...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.034
更新日期：2015-07-01 00:00:00
abstract：:Prolonged exposure of opioid receptors to agonists leads to their regulation by the classical process of clathrin-dependent internalization, followed by their intracellular degradation (down regulation). We have previously shown that the opioid agonist etorphine induced an additional process of down regulation of mu-o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.040
更新日期：2011-04-22 00:00:00
abstract：:The present study examined whether morphine and morphine-6beta-glucuronide (M6G) analgesia on the tail-flick and jump tests differed in potency in the periaqueductal gray, the locus coeruleus or the rostral ventromedial medulla. Morphine and M6G significantly and dose-dependently elicited analgesia on both nociceptive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00520-4
更新日期：1998-07-20 00:00:00
abstract：:The blink reflex consists of an early, pontine R1-component and a late, medullary R2-component. R1 and R2 can be evoked by innocuous stimuli, but only the R2 also by painful heat, suggesting that the R2 is mediated by wide dynamic range neurons (WDR) of the spinal trigeminal nucleus. Remote noxious stimuli suppress th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00646-5
更新日期：1998-08-24 00:00:00
abstract：:Neurological problems can develop when blood glucose levels rapidly rise or fall yet there has been little experimentation at a cellular level to assess how neurophysiological change may be induced. Using intracellular recording in the rat neocortical slice preparation, we examined pyramidal neurons of layers II-III a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90859-t
更新日期：1991-07-26 00:00:00
abstract：:Bilateral removal of the cortical visual area in newborn cats produces degeneration of retinal ganglion cells. Measurements of over 4,000 cells and calculation of neuron densities from sample areas of retina in the adult show that the medium sized cell population in peripheral retina is reduced by 68%, whereas the pop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90480-7
更新日期：1981-05-18 00:00:00
abstract：:Recently we reported that chronic treatment with 17beta-estradiol (E2) or tamoxifen (TAM) regulates the ovariectomy-induced downregulation of the key molecules linked to hippocampal synaptic plasticity and signal transduction pathway. We now report modulation of the antiapoptotic (Bcl-2) and proapoptotic (Bax) protein...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.080
更新日期：2008-04-14 00:00:00
abstract：:Expertise offers a unique insight into how our brain functions. The purpose of this experiment was to determine if motor system activity and functional connectivity between the cognitive system and sensorimotor system is differentially modulated by an individual's level of expertise. This goal was achieved through the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.09.048
更新日期：2013-12-02 00:00:00
