Abstract:
:The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is implicated in the temporal organization of circadian rhythms in a variety of physiological, endocrine and behavioral processes. There is a great deal of evidence indicating that aging is characterized by a progressive deterioration of circadian timekeeping. The present study was aimed at investigating whether there are age-related changes in circadian rhythmicity of the vasopressin (VP)-producing neurons in the human SCN. To that end brains obtained at autopsy of 39 subjects, ranging in age from 6 to 91 years, were studied. Subjects were divided into two age groups, viz. 'young subjects' (up to 50 years) and 'elderly subjects' (over 50 years). It is shown that the number of VP-immunoreactive neurons in the human SCN exhibits a marked diurnal oscillation in young, but not in elderly, people. Whereas in young subjects low VP-immunoreactive neuron numbers were found during the night period (22:00-06:00 h) and peak values during the early morning (06:00-10:00 h), the SCN of elderly people showed a reduced amplitude and a tendency for a reversed diurnal pattern with high instead of low values during the night. The findings suggest that the VP synthesis of the human SCN exhibits a circadian rhythm that is disrupted later in life.
journal_name
Brain Resjournal_title
Brain researchauthors
Hofman MA,Swaab DFdoi
10.1016/0006-8993(94)90689-0subject
Has Abstractpub_date
1994-07-18 00:00:00pages
134-42issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90689-0journal_volume
651pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Distribution of the monocarboxylate transporter MCT1 has been investigated in the cortex of normal adult human brain. Similarly to the glucose transporter GLUT1 55 kDa isoform, MCT1 was found to be strongly expressed on blood vessels in all cortical layers. In addition, laminar analysis revealed intense MCT1 expressio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.064
更新日期:2006-01-27 00:00:00
abstract::The main purpose of the present study was to determine whether specific regions of the mouse brain exhibit different age-related changes in oxidative stress, as indicated by glutathione redox state and the level of protein-glutathionyl mixed disulfides. Comparison of 3- and 21-month-old mice indicated an age-related d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.040
更新日期:2007-01-05 00:00:00
abstract::Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91050-5
更新日期:1988-05-24 00:00:00
abstract::The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91533-1
更新日期:1985-02-18 00:00:00
abstract::In the present study, we observed chronological changes of antioxidant-like protein 1 (AOP-1) in the gerbil hippocampal CA1 region after 5 min of transient forebrain ischemia using immunohistochemistry and western blot. AOP-1 was significantly altered in the CA1 region after transient ischemia. In the sham-operated gr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.022
更新日期:2005-11-16 00:00:00
abstract::Accumulating evidence suggests that the neuropeptide substance P (SP) and its principal receptor neurokinin 1 (NK1) play a specific role in the behavioral response to opioids and stress that may help to initiate and maintain addictive behavior. In animal models, the NK1 receptor is required for opioids to produce thei...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2009.11.014
更新日期:2010-02-16 00:00:00
abstract::Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90284-5
更新日期:1981-08-24 00:00:00
abstract::The activity of the septo-hippocampal and nucleus basalis-cortical cholinergic pathways was investigated by measuring changes in the extracellular acetylcholine levels in the hippocampus and parietal cortex, by means of transversal microdialysis, during the acquisition and recall of a positively reinforced operant beh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00292-2
更新日期:1996-06-10 00:00:00
abstract::Despite significant advancements in the understanding of the pathophysiological mechanisms of subarachnoid hemorrhage (SAH), little is known about the emotional consequences. The primary goal of this study was to describe the locomotor and behavioral patterns in rats following both a single-injection and double-inject...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.10.061
更新日期:2013-01-23 00:00:00
abstract::Anterograde and retrograde tracing experiments employing WGA-HRP were used to identify an auditory projection area within the frontal telencephalon of the pigeon. The projection originates in a nucleus of the lateral lemniscus, travels with the quintofrontal tract and terminates within nucleus basalis. The location of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91499-x
更新日期:1986-11-29 00:00:00
abstract::Unitary discharges in the efferent ciliary nerves were studied in cervical sympathectomized rabbits. In all, 279 units were recorded and categorized, except 7 units, into the following 3 types from their responses to photic and other stimuli, i.e. type A (170 units), type B (42 units) and type C (60 units). Type A uni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90254-1
更新日期:1980-03-17 00:00:00
abstract::We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy. In the dose range of 0.75 to 10 mg/kg s.c., KA dose-dependently induced characteristic behavioural changes. Partial depletion of noradrenaline (NA) a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90219-9
更新日期:1989-08-28 00:00:00
abstract::Anticipation of an unavoidable painful stimulation, i.e. anticipation stress, induces analgesia. This analgesia may result from activation of the endogenous opioid peptide system as it is blocked by naloxone. The present paper characterizes the anticipation stress further by following the kinetics of the analgesia ris...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91674-0
更新日期:1989-12-04 00:00:00
abstract::This study determined baroreceptor reflex (BR) function in conscious rats which had received sham or electrolytic lesions of the anteroventral third ventricle (AV3V) 54-56 days previously. Resting mean arterial pressure (MAP) and heart rate (HR) values of the AV3V-lesion rats were similar to those of sham-lesion rats ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01561-9
更新日期:1999-07-24 00:00:00
abstract::cAMP-dependent regulation of the steady-state mRNA levels for the ECM components, laminin A, B1 and B2 chains, collagen types I, III and IV were examined by Northern blot analysis in cultured rat Schwann cells. ECM mRNAs of laminin B1 chain and collagen types I and IV were expressed at high levels in the control Schwa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90409-x
更新日期:1994-08-08 00:00:00
abstract::In order to obtain further insight into the interactions between the purinergic and dopaminergic pathways in the striatum, we studied both metabolisms simultaneously, using a microdialysis technique in 1-methyl-1,4-phenylpyridinium ion (MPP+) unilaterally-denervated conscious rats. In these rats the contralateral side...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90052-8
更新日期:1989-03-27 00:00:00
abstract::Examination of the projection from area 2 of the sensory cortex to the motor cortex revealed substantial changes following lesion of the ventrolateral nucleus of the thalamus. These observed changes were as follows. (1) The polarity of the evoked potentials elicited by area 2 stimulation reversed in the depth of the m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90838-8
更新日期:1985-10-14 00:00:00
abstract::The second phase of Ca2+ transients (aequorin luminescence) which was not accompanied by twitch tensions were generated by 0.3 microM neostigmine in indirectly-stimulated diaphragm muscles of mice. This phase was dependent on external [Ca2+]o, was inhibited by a low concentration of (+)-tubocurarine (+)-TC; 0.013-0.13...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90287-l
更新日期:1990-01-22 00:00:00
abstract::Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament lig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03138-4
更新日期:2002-09-27 00:00:00
abstract::After transplantation of autologous sciatic nerve segments into the retina of adult hamsters for 1-2 months, retrograde labelling with horseradish peroxidase demonstrated a population of ganglion cells situated peripheral to the graft. If an additional lesion was placed between the insertion of the graft and the optic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91203-5
更新日期:1986-07-02 00:00:00
abstract::Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90488-9
更新日期:1986-04-09 00:00:00
abstract::The immunolocalization of the 14-3-3 eta isoform in the anterior horn cells (AHCs) of patients with sporadic amyotrophic lateral sclerosis (ALS) and controls was examined. Compared with the immunolocalization of other 14-3-3 isoforms, the immunolocalization of the 14-3-3 eta isoform was either synaptic at the peripher...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.05.051
更新日期:2016-09-01 00:00:00
abstract::The release of [3H]acetylcholine (ACh) from 6-, 8-, 10-, 12-, 14- and 16-day chick embryo neural retina layers was determined using a perfusion system to collect the released neurotransmitter. After labeling the tissue with [3H]choline, samples of [3H]ACh released before and after stimulation by 80 mM KCl or 5 mM glut...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90137-7
更新日期:1982-07-01 00:00:00
abstract::Temporal changes in cholinergic functions following transient cerebral ischemia (10 min) were studied in the hippocampus of awake unrestrained gerbils using in vivo microdialysis. These data were compared with the results for temporal change in the area of each CA1 cell soma, measured with a microcomputer imaging devi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91765-5
更新日期:1994-03-07 00:00:00
abstract::In rats raised from birth under a regular dark-light cycle, retinal dopamine (DA) levels were low at 12 days, increased progressively and steeply at 16, 20, 30 and 60 days and peaked at about 75 days postnatally. Dark-rearing from birth suppressed the magnitude of the normal developmental pattern of DA concentrations ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90293-2
更新日期:1986-05-01 00:00:00
abstract::PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90184-7
更新日期:1984-11-12 00:00:00
abstract::Our research group recently presented the distribution of thyrotropin-releasing hormone (TRH) in the chicken brain. In this study we measured somatostatin (SRIH) concentrations in different brain parts and nuclei. The distribution of SRIH and TRH in peripheral tissues was also studied. Although the highest SRIH conten...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02550-6
更新日期:2000-08-11 00:00:00
abstract::The connectivity of the stellate ganglion of Octopus was investigated using cobalt and horseradish peroxidase (HRP) tracers applied to severed preganglionic and postganglionic nerves. Centripetal cells, defined as cells in the ganglion which send their axons back toward the brain, were discovered by both methods. Appl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90583-1
更新日期:1980-02-17 00:00:00
abstract::In barbiturate-anaesthetized spinal cats, antibody microprobes were used to examine immunoreactive substance P (irSP) release at sites within the spinal cord following cutaneous stimuli. A basal level of irSP release was detected in the region of the substantia gelatinosa of the lumbar spinal cord. No increase in this...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90771-8
更新日期:1988-06-07 00:00:00
abstract::To determine the presence and distribution of cerebrovascular Abeta production we investigated amyloid beta precursor protein (AbetaPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AbetaPP-mRN...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01361-x
更新日期:1999-05-15 00:00:00