Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma.

abstract：:Retinal and tectal potentials to alternating gratings were recorded in pigeons raised monocularly deprived. Deprived eyes showed consistent myopia and anterior-posterior axis elongation. In addition, vitreal opacities were observed in 70% of the deprived eyes. In pigeons with vitreal opacities, a reduction of retinal ...

journal_title：Brain research

authors： Bagnoli P,Porciatti V,Francesconi W

更新日期：1985-07-15 00:00:00

abstract：:Abrupt withdrawal from chronic alcohol exposure can produce convulsions that are likely due to ethanol (EtOH) neuroadaptations. While significant efforts have focused on elucidating dependence mechanisms, the alterations contributing to EtOH withdrawal severity are less well characterized. The present studies examined...

journal_title：Brain research

authors： Beadles-Bohling AS,Wiren KM

更新日期：2005-06-07 00:00:00

abstract：:The non-cholinergic slow excitatory postsynaptic potential (EPSP) in the guinea pig inferior mesenteric ganglion (IMG) is believed to be mediated by substance P (SP). Yet, in ganglia of guinea pigs treated with capsaicin (50, 100, or 350 mg/kg, s.c.), a compound that depletes SP from sensory neurons, slow EPSPs were o...

journal_title：Brain research

authors： Peters S,Kreulen DL

更新日期：1984-06-11 00:00:00

abstract：:Intracerebroventricular administration of 10--20 microgram of steroid-O-sulfates induced hypermotility, agitation, salivation, EEG abnormalities, stereotypies, wet dog shakes and seizures. Equivalent effects resulted from 30--200 microgram morphine sulfate (H2SO4 salt), 50 microgram EGTA or 300--400 microgram of sodiu...

journal_title：Brain research

authors： LaBella FS,Havlicek V,Pinsky C

更新日期：1979-01-12 00:00:00

abstract：:A study was undertaken of the possible relationship of the binding affinity of a series of anticholinergic psychotomimetic drugs to their psychopharmacological and anticholinergic effects. Binding was measured to brain homogenates and nerve endings using [3H]quinuclidinyl benzilate (QB), a highly potent psychotomimeti...

journal_title：Brain research

authors： Baumgold J,Abood LG,Aronstam R

更新日期：1977-03-25 00:00:00

abstract：:The two primary categories of stroke, ischemic and hemorrhagic, both have fundamentally different mechanisms and thus different treatment options. These two stroke categories were applied to rat models to identify potential biomarkers that can distinguish between them. Ischemic stroke was induced by middle cerebral ar...

journal_title：Brain research

authors： Ren C,Zoltewicz S,Guingab-Cagmat J,Anagli J,Gao M,Hafeez A,Li N,Cao J,Geng X,Kobeissy F,Mondello S,Larner SF,Hayes RL,Ji X,Ding Y

更新日期：2013-12-02 00:00:00

abstract：:Using the acetylthiocholine staining method, it was possible to visualize acetylcholinesterase (AChE)-stained neuronal cell bodies and nerve endings as well as AChE-positive vesicles in the rat duodenum. AChE-reactive perikarya were seen with certainty only in the myenteric plexus. They were 40 micron in diameter and ...

journal_title：Brain research

authors： Wolter HJ

更新日期：1985-07-29 00:00:00

abstract：:The role of mu opioid receptors in the nucleus raphe dorsalis (DR) in the control of apomorphine-induced aggression was studied in rats. Administration in the DR of a selective mu opioid receptor agonist, (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO), in doses ranging from 0.01 to 1 microgram/0.5 microliter, dose-depen...

journal_title：Brain research

authors： Giraud O,Cervo L,Grignaschi G,Samanin R

更新日期：1989-05-29 00:00:00

abstract：:cAMP-dependent regulation of the steady-state mRNA levels for the ECM components, laminin A, B1 and B2 chains, collagen types I, III and IV were examined by Northern blot analysis in cultured rat Schwann cells. ECM mRNAs of laminin B1 chain and collagen types I and IV were expressed at high levels in the control Schwa...

journal_title：Brain research

authors： Yamamoto M,Sobue G,Li M,Mitsuma T,Kimata K,Yamada Y

更新日期：1994-08-08 00:00:00

abstract：:We have examined the effects of isotonic hypovolemia on the expression of the neuronal nitric oxide synthase (nNOS) gene in the paraventricular (PVN) and supraoptic nuclei (SON) of the rat, using in situ hybridization histochemistry with a 35S-labelled oligodeoxynucleotide probe complementary to nNOS mRNA. Intraperito...

journal_title：Brain research

authors： Ueta Y,Levy A,Lightman SL,Hara Y,Serino R,Nomura M,Shibuya I,Hattori Y,Yamashita H

更新日期：1998-04-20 00:00:00

abstract：:Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched ...

journal_title：Brain research

authors： Hugyecz M,Mracskó E,Hertelendy P,Farkas E,Domoki F,Bari F

更新日期：2011-08-02 00:00:00

abstract：:Nerve-evoked muscle depolarisation plays an important role in the downregulation of extrasynaptic AChRs which accompanies the increase in synaptic AChR expression at the neuromuscular junction during embryonic development. However, additional mechanisms may be involved in the AChR downregulation. This study provides e...

journal_title：Brain research

authors： Montgomery JM,Fleming JS,Mills RG

更新日期：1999-02-13 00:00:00

abstract：:The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the develop...

journal_title：Brain research

authors： Grund T,Teuchert-Noodt G,Busche A,Neddens J,Brummelte S,Moll GH,Dawirs RR

更新日期：2007-10-24 00:00:00

abstract：:The effect of MK-801 on striatal dopamine (DA) release was investigated by using an in vivo microdialysis technique in the freely moving rat. Systemic injection of MK-801 (0.25, 0.5, 1, 2 mg/kg, i.p.) reduced the extracellular level of DA significantly and produced no change in the level of 3,4-dihydroxyphenylacetic a...

journal_title：Brain research

authors： Kashihara K,Hamamura T,Okumura K,Otsuki S

更新日期：1990-09-24 00:00:00

abstract：:Focal electrical stimulation and glutamate microinjection in the nuclei reticularis gigantocellularis (NGC) and gigantocellularis pars alpha (NGC alpha) both inhibit the nociceptive tail-flick (TF) reflex in rats. The present experiments were undertaken to determine the transmitter(s) at the level of the lumbar spinal...

journal_title：Brain research

authors： Zhuo M,Gebhart GF

更新日期：1990-12-03 00:00:00

abstract：:The present work shows the existence of adenosine-dependent cyclic adenosine monophosphate (AMP) accumulation in the chick optic tectum. When tecta from 18-day-old embryos were incubated with the phosphodiesterase inhibitor IBMX and RO 20-1724, the cyclic AMP level increased from 39.2 to 73.3 and 285.5 pmol/mg protein...

journal_title：Brain research

authors： Ventura AL,Paes de Carvalho R

更新日期：1987-09-01 00:00:00

abstract：:Dorsal temporal pole (dTP) is a cortical region at the rostral end of the superior temporal gyrus that forms part of the ventral auditory object processing pathway. Anatomical connections with frontal and medial temporal areas, as well as a recent single-unit recording study, suggest this area may be an important part...

journal_title：Brain research

authors： Bigelow J,Ng CW,Poremba A

更新日期：2016-06-01 00:00:00

abstract：:Diazoxide (DZ), a highly selective opener of the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel, has neuroprotective effects. However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. In this study, we investigated DZ attenuating neuronal los...

journal_title：Brain research

authors： Xue Y,Xie N,Lin Y,Xu J,Han Y,Wang S,Jiang H,Chi Z

更新日期：2011-04-06 00:00:00

abstract：:The regulation of spike generation in rat midbrain dopamine (DA) neurons was investigated using in vitro intracellular recordings. DA neurons fired long (greater than 1.8 ms) action potentials that exhibited comparatively depolarized spike thresholds (approx. -35 to -45 mV). Depolarization of the DA neuron increased t...

journal_title：Brain research

authors： Grace AA

更新日期：1990-07-30 00:00:00

abstract：:Cigarette smoke passed through the nasal cavity of atenolol pre-treated anesthetized spontaneously breathing rabbits caused a bradycardia which was significantly modified by intracisternal application of the 5-HT1A receptor ligands 8-OH-DPAT (50 micrograms.kg-1) and buspirone (200 micrograms.kg-1). 8-OH-DPAT attenuate...

journal_title：Brain research

authors： Futuro-Neto HA,Pires JG,Gilbey MP,Ramage AG

更新日期：1993-12-03 00:00:00

abstract：:Calretinin-immunoreactive structures in the anterior olfactory nucleus of the rat were studied using a polyclonal antibody, which does not cross-react with the highly homologous calcium-binding protein calbindin-D28k, and the avidin-biotin-peroxidase technique. Calretinin-immunopositive neurons were found in all regio...

journal_title：Brain research

authors： García-Ojeda E,Alonso JR,Briñón JG,Rogers J,Weruaga E,Arévalo R,Aijón J

更新日期：1998-04-06 00:00:00

abstract：:The intracellular localization of the serine protease plasminogen activator was analyzed in homogenates of bovine brain cortex using differential fractionation procedures. The distribution of the enzyme was clearly different from that of cytosol and mitochondrial markers, and was similar to that of plasma membrane pro...

journal_title：Brain research

authors： Zisapel N,Miskin R,Laudon M,Soreq H

更新日期：1982-09-23 00:00:00

abstract：:ATP has been recognized as an important extracellular signaling molecule and P2X receptors are membrane ion channels activated by the binding of extracellular ATP. Since both AQP4 and P2X7 receptor (P2X7R) are known to be present in astrocytes, we examined whether P2X7R activation plays a role in the regulation of AQP...

journal_title：Brain research

authors： Lee M,Lee SJ,Choi HJ,Jung YW,Frøkiaer J,Nielsen S,Kwon TH

更新日期：2008-02-21 00:00:00

abstract：:Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...

journal_title：Brain research

authors： Han Q,Liu S,Li Z,Hu F,Zhang Q,Zhou M,Chen J,Lei T,Zhang H

更新日期：2014-01-13 00:00:00

abstract：:Recent studies suggest that 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, can have direct effects on blood vessels beyond their cholesterol-lowering effects. We investigated the effects of atorvastatin on the functional and structural properties of blood-brain barrier (BBB) and the act...

journal_title：Brain research

authors： Kalayci R,Kaya M,Elmas I,Arican N,Ahishali B,Uzun H,Bilgic B,Kucuk M,Kudat H

更新日期：2005-05-03 00:00:00

abstract：:The triggering of ectopic action potentials (APs) at axon terminals in a chronic epileptic cobalt focus was investigated in thalamocortical (TC) neurons of rats under urethane anesthesia. TC cells which were in register with an active epileptic aggregate discharged bursts of 2-11 APs. According to the rules of the col...

journal_title：Brain research

authors： Pinault D

更新日期：1992-03-27 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) expression changes in the dorsal root ganglion (DRG) and spinal cord in some pain models. Recently, rat BDNF transcripts containing novel 5' untranslated exons were identified and characterized, and a new numbering system for rat BDNF exons was introduced. We examined the expre...

journal_title：Brain research

authors： Kobayashi H,Yokoyama M,Matsuoka Y,Omori M,Itano Y,Kaku R,Morita K,Ichikawa H

更新日期：2008-04-24 00:00:00

abstract：:The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL). DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacen...

journal_title：Brain research

authors： Koroleva VI,Korolev OS,Loseva E,Bures J

更新日期：1998-03-09 00:00:00

abstract：:The distributions and inductions of Cu/Zn superoxide dismutase (SOD), neuronal and endothelial nitric oxide (NO) synthase (nNOS and eNOS), and nitrotyrosine (NT) were immunohistochemically examined in rabbit spinal cords after 5 and 15 min of transient ischemia. The neurons in the anterior horns (AH) were selectively ...

journal_title：Brain research

authors： Watanabe M,Sakurai M,Abe K,Aoki M,Sadahiro M,Tabayashi K,Okamoto K,Shoji M,Itoyama Y

更新日期：1996-09-02 00:00:00

abstract：:Three hours after administration of the pro-oxidant 2-cyclohexen-1-one, calpain activity was significantly reduced in the brain of young rats, but not in the brain of adult rats, and cathepsin D activity remained unchanged. Addition of isovalerylcarnitine to the incubation medium increased calpain activity 5-7-fold, c...

journal_title：Brain research

authors： Benuck M,Banay-Schwartz M,Ramacci MT,Lajtha A

更新日期：1992-11-20 00:00:00