Abstract:
:Morphological changes in neocortical somatostatin- and neuropeptide-Y-immunoreactive cells in senile dementia of the Alzheimer type (SDAT) were studied using light-microscopic immunohistochemical methods. The density of somatostatin-immunoreactive cells in the neocortex did not decrease in cases of SDAT compared with aged normal subjects. However, many somatostatin-positive fibers were abnormally swollen and bulbous in shape and they were often observed within senile plaques. The morphology of these swollen and bulbous fibers was similar to that of the swollen neurites present in senile plaques demonstrated by the silver-impregnation method. Similar fiber abnormalities were observed in sections stained with antibodies to neuropeptide Y. Somatostatin-positive cells in aged normal subjects were distributed from layer II through to the subcortical white matter. These cells were multipolar, bitufted, or pyramidal in shape, with the majority of cells being of the multipolar type. Neuropeptide Y-positive cells also were distributed from layer II through to the subcortical white matter. Most of these cells were multipolar, but a few bipolar cells were also observed. We suggest that a primary degenerative process might begin at the fiber terminals of the somatostatin neuronal system in the neocortex in SDAT.
journal_name
Brain Resjournal_title
Brain researchauthors
Nakamura S,Vincent SRdoi
10.1016/0006-8993(86)91099-1subject
Has Abstractpub_date
1986-04-02 00:00:00pages
11-20issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)91099-1journal_volume
370pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Production of inflammatory cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6), in the brain is increased in various diseases. To investigate the relationships between the effect of overproduction of IL-6 in the brain on central and peripheral production of TNF, IL-1 beta an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00865-7
更新日期:1996-11-18 00:00:00
abstract::Experimental thiamine deficiency (TD) is a model of impaired oxidative metabolism associated with region-selective neuronal loss in the brain. Oxidative stress is a prominent feature of TD neuropathology, as evidenced by the accumulation of heme oxygenase-1 (HO-1), ferritin, reactive iron and superoxide dismutase in m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02933-4
更新日期:2000-12-01 00:00:00
abstract::Antibodies to dopamine beta-hydroxylase (anti-D beta H) were taken up by noradrenergic nerve terminals in the iris following attachment to D beta H, and were transported back to, and accumulated in, the superior cervical ganglion (SCG). Concurrent, or prior destruction of noradrenergic terminals with 6-hydroxydopamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91097-7
更新日期:1984-06-03 00:00:00
abstract::Peripheral nerve fascicles are deliberately impaled during microneurography experiments. We have assessed conduction block under these circumstances. First we recorded compound action potentials (CAP) in the sural nerve following stimulation of the sciatic nerve. The insertion of injection and microneurography electro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91538-4
更新日期:1993-12-24 00:00:00
abstract::A histo-enzymatic technique for visualizing and quantifying endogenous NAD(H) in brain tissue was developed, based on coupled enzymatic cycling reactions that reduce nitrotetrazolium blue chloride to produce formazan. Conditions were used where the endogenous level of nicotinamide adenine dinucleotides (NAD(H)) was th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.12.042
更新日期:2010-02-26 00:00:00
abstract::Dexmedetomidine (Dex) has the neuroprotective effect on cerebral ischemia-reperfusion injury (CIRI). But the mechanism is not yet clear. In this study, we established a model of middle cerebral artery occlusion (MCAO) and treated primary cortical neurons with oxygen glucose deprivation (OGD), followed by Dex treatment...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.09.007
更新日期:2018-12-15 00:00:00
abstract::The role of the substantia innominata (SI) in the generation of a behavior mediated by the prefrontal (PF) cortex was examined in two Japanese monkeys. PF neuronal activities related to a visual tracking task by wrist movement were recorded and neural responses to SI stimulation were analyzed. Sixty-six neurons showed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90734-5
更新日期:1983-10-16 00:00:00
abstract::'Feedback' signals from mammalian extrastriate visual cortices are reported to exert primarily an excitatory influence on the classical receptive field (CRF) of neurons in the primary visual cortex (V1). However, given the much larger CRFs of neurons in extrastriate visual cortices it is not yet understood how feedbac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.069
更新日期:2010-04-30 00:00:00
abstract::The nature of the delayed blood-brain barrier (BBB) opening that occurs in rats subjected to forebrain ischemia by the technique of two-vessel (carotid) occlusion plus hypovolemic hypotension (2VO ischemia) was probed by examining the simultaneous, trans-barrier movement of two hydrophilic, normally poorly permeative ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00323-5
更新日期:1997-06-27 00:00:00
abstract::The growth inhibitory factor (GIF) is a new metallothionein (MT)-like protein that is downregulated in Alzheimer's disease (AD) brain. The biological function of GIF has not been fully clarified yet. We have raised an antibody to the synthetic polypeptide that is specific for rat GIF. The purified antibody reacted to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00522-r
更新日期:1995-08-07 00:00:00
abstract::The possible interference of nitric oxide (NO) in glucose metabolism was studied in activated astrocytes. Lipopolysaccharide (LPS) treatment triggered a NO-mediated increase in glucose consumption and lactate production, suggesting an enhanced rate of glycolysis. Active glycogen synthesis was also observed after LPS t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02877-9
更新日期:2002-07-26 00:00:00
abstract::When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90076-2
更新日期:1982-10-14 00:00:00
abstract::The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00908-6
更新日期:1997-10-10 00:00:00
abstract::Total RNA was extracted from 15-day-old whole rat brains. Microinjection of the RNA into Xenopus laevis oocytes induced electrophysiological responsiveness to cholecystokinin-8 (CCK) and bombesin (BBS) but not to corticotropin-releasing factor (CRF) or somatostatin. The responses to CCK and BBS were similar in shape, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(88)90021-6
更新日期:1988-08-01 00:00:00
abstract::Sleep-related changes-including modification in sensory processing-that influence brain and body functions, occur during both slow wave and paradoxical sleep. Our aim was to investigate how cortical auditory neurons behave during the sleep/waking cycle, and to study cell firing patterns in relation to the processing o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01194-9
更新日期:1999-01-23 00:00:00
abstract::The number of hypocretin-containing neurons is markedly decreased in most patients with the sleep disorder narcolepsy. It is presently not known why the loss of hypocretin neurons occurs in these patients. In the present study, we tested the role of inflammation in the degeneration of hypocretin neurons. The proinflam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.016
更新日期:2004-09-03 00:00:00
abstract::The role of N-methyl-D-aspartate (NMDA) receptors in specific D1 and D2 regulation of striatal and accumbens neurotensin (NT) systems was investigated. As demonstrated previously, stimulation of D1 receptors with multiple administrations of SKF 38393 significantly increased striatal and accumbens NT content to approxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90663-t
更新日期:1992-02-07 00:00:00
abstract::This study was designed to assess effects of insulin-induced hypoglycemia on plasma and cerebrospinal fluid (CSF) levels of immunoreactive (ir) beta-endorphins, adrenocorticotropin (ACTH), cortisol, norepinephrine, insulin, and glucose in the conscious, overnight fasted dog. Dogs received either an intravenous infusio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90475-1
更新日期:1988-08-23 00:00:00
abstract::The blood-brain barrier (BBB) restricts the entry of antiviral agents into the CNS thereby facilitating the creation of a reservoir of HIV that could potentially reinfect peripheral tissues. We characterized the efflux from brain of radioactively labeled viral coat HIV-1 gp120 (I-gp120) after intracerebroventricular (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01069-0
更新日期:1999-03-20 00:00:00
abstract::The aim of this study was to investigate the relationship between serum metabolomic biomarkers and brain in vivo magnetic resonance spectroscopy (MRS) biomarkers in patients with Parkinson's disease (PD) as well as to investigate compound concentration changes by comparing the results with healthy control subjects. Un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147118
更新日期:2020-12-01 00:00:00
abstract::Previous studies have shown that microinjection of morphine into the prefrontal ventrolateral orbital cortex (VLO) produces antinociception. The current study examined whether gamma-aminobutyric acid (GABA) containing neurons in the VLO were involved in this antinociception. Under light anesthesia, the GABA(A) recepto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.067
更新日期:2006-02-16 00:00:00
abstract::Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.029
更新日期:2009-12-15 00:00:00
abstract::Chick neural cultures were used to study effects of insulin, thyrotropin releasing hormone, growth hormone and glucagon on myelin lipid synthesis in vitro. The incorporation of [3H]galactose into myelin associated lipids such as cerebroside and sulfatide was used as an index for various hormonal effects on myelination...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90831-0
更新日期:1986-04-16 00:00:00
abstract::The muscarinic cholinergic receptor of rat eccrine sweat gland was characterized using quantitative autoradiography and [3H]QNB as radioligand. The distribution of radioligand was maximal in the secretory coil. Autoradiographic competition binding studies were performed using selective antagonists to M1 (pirenzepine),...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90415-r
更新日期:1991-05-31 00:00:00
abstract::Electrical stimulation of the sural nerve (SN) revealed input from sural nerve afferents to L6 and L7 dorsal horn neurons that were not apparent using natural mechanical stimuli, especially in cells with variable latency responses to SN stimulation. Nearly all (31/32) cells that had reliable, fixed latency responses t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90816-4
更新日期:1986-04-16 00:00:00
abstract::Near-infrared spectroscopy (NIRS) enables noninvasive measurement of concentration changes of oxy- and deoxy-hemoglobin. The present study investigated cerebral representations of motion illusion by NIRS and examined several experimental procedures to determine an efficient procedure that can shorten the experimental ...
journal_title:Brain research
pub_type: 临床试验,杂志文章
doi:10.1016/j.brainres.2005.11.050
更新日期:2006-03-10 00:00:00
abstract::Axonal projections of ganglion cells to the superior colliculus (SC) and to the nucleus of the optic tract (NOT) were re-examined physiologically in the cat's retina. Taking care to minimize current spreads around the stimulating electrodes placed in the NOT or the SC, we reached a conclusion that a substantial propor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91465-9
更新日期:1985-08-19 00:00:00
abstract::The spinal nucleus of the bulbocavernosus (SNB) is a sexually dimorphic group of motoneurons in Rexed's Lamina X of the lumbosacral spinal cord of the Mongolian gerbil. The SNB innervates the perineal musculature, the bulbocavernosus (BC), levator ani (LA), and external anal sphincter (EAS). Recent studies demonstrate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02949-9
更新日期:2002-10-25 00:00:00
abstract::Preferential uptake of dopamine occurred in mesocortical vs striatal synaptosomes obtained from acutely fighting isolated male ICR mice. Specifically, both Km and Vmax were significantly increased in the prefrontal cortex but not the caudate-putamen. The findings are similar to selective changes in mesocortical activi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90954-9
更新日期:1981-10-05 00:00:00
abstract::Parkinson's Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive imp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.03.035
更新日期:2019-01-01 00:00:00