Abstract：
:The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve as important mediators of the pathogenic processes that lead to irrevocable neural injury and of countervailing homeostatic and regenerative responses. Epigenetics is, therefore, of considerable translational significance to the field of neuroprotection. In this brief review, we provide an overview of epigenetic mechanisms and highlight the emerging roles played by epigenetic processes in neural cell dysfunction and death and in resultant neuroprotective responses. This article is part of a Special Issue entitled SI: Neuroprotection.
journal_name
Brain Resjournal_title
Brain researchauthors
Qureshi IA,Mehler MFdoi
10.1016/j.brainres.2015.07.034subject
Has Abstractpub_date
2015-12-02 00:00:00pages
265-272issue
Pt Beissn
0006-8993issn
1872-6240pii
S0006-8993(15)00577-6journal_volume
1628pub_type
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