Abstract:
:Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is considered to play a crucial role in the development of post-ischemic neuronal injury, such as ischemic stroke. The present study was undertaken to clarify the beneficial effects of MP-124, a novel PARP-1 inhibitor, on neurological deficits and cerebral infarcts following middle cerebral artery occlusion (MCAO) in the monkey. The effects of MP-124 on cerebral infarcts and neurological deficits in monkeys were investigated in permanent MCAO (pMCAO) and transient MCAO (tMCAO) models. In a dose-dependency study, the neurological deficits and cerebral infarct volume were assessed at 28h after pMCAO. MP-124 significantly reduced the total infarct volume, including that in the cortex/white matter and striatum, at doses of 0.3, 1 and 3mg/kg/h by 22, 54 and 64%, respectively. In addition, MP-124 at all doses significantly reduced the overall neurological deficits. Such ameliorative effects of MP-124 were observed in female as well as male monkeys. In the therapeutic time window (TTW) study, the neurological deficits and cerebral infarct volume were assessed at several time points after pMCAO or tMCAO. Treatment with MP-124 at 3 and 6h after MCAO significantly ameliorated not only the neurological deficits but also the infarct volume. MP-124 is thought to exhibit neuroprotective effects with a broad TTW regardless of sex in MCAO models. Such findings suggest that MP-124 may be beneficial for the treatment of acute ischemic stroke.
journal_name
Brain Resjournal_title
Brain researchauthors
Matsuura S,Egi Y,Yuki S,Horikawa T,Satoh H,Akira Tdoi
10.1016/j.brainres.2011.05.069subject
Has Abstractpub_date
2011-09-02 00:00:00pages
122-31eissn
0006-8993issn
1872-6240pii
S0006-8993(11)01161-9journal_volume
1410pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::In Long-Evans Cinnamon (LEC) rats of three different ages (7, 13 and 32 weeks old) concentrations of Cu, Zn and Fe were measured in 8 regions of the brain. The LEC groups aged 7 and 13 weeks showed low concentrations of Cu in all regions compared to Long-Evans Agouti (LEA) rats. In 32-week-old LEC rats, however, Cu co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91587-5
更新日期:1992-08-21 00:00:00
abstract::3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine. DOPEGAL, but not other metabolites, kills differentiated PC-12 cells. However, the type of DOPEGAL induced cell death, whether necrosis or apoptosis, is not known. To determine the type of cell death tr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00447-2
更新日期:1997-06-20 00:00:00
abstract::Horseradish peroxidase (HRP, 30% solution, 0.1-0.3 mul, 72 h) was injected unilaterally into the basal striatum (STR) and the dorsal ventricular ridge (DVR) of adult turtles (Chrysemys picta) in order to demonstrate the cells of origin of some afferents to these telencephalic structures. After selective STR injection,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90161-x
更新日期:1976-05-21 00:00:00
abstract::Both enkephalin and 5-hydroxytryptamine (5-HT) have been implicated in neural mechanisms underlying the central control of respiration. In view of the role of the nuclei tractus solitarii (NTS) in respiratory regulation, we carried out a study in artificially ventilated, chloralose-anaesthetized cats of the effects of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91515-x
更新日期:1985-02-18 00:00:00
abstract::We have previously reported that intracerebroventricular (i.c.v.) injection of either a PKC or PKA inhibitor completely reversed the expression of 5- to 8-fold morphine antinociceptive tolerance. We developed a model of 45-fold morphine tolerance that included a 75-mg morphine pellet and twice daily morphine injection...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03170-6
更新日期:2003-09-19 00:00:00
abstract::Short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) are well-known transcranial magnetic stimulation (TMS) paradigms used to probe the sensorimotor system. To date, there is a paucity of research examining the reliability of these neurophysiological measures. This information is required...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146394
更新日期:2019-11-15 00:00:00
abstract::Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90611-x
更新日期:1991-05-17 00:00:00
abstract::In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study included serial examinations (n = 31; plasma Phe levels: 0.47-2.24 mmol/l) of patients either receiving a Phe-restricted diet (200 mg ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01054-8
更新日期:1997-12-19 00:00:00
abstract::In scrapie infection, prion protein (PrPSc) is localized in areas where there is neurodegeneration and astrocytosis. It is thought that PrPSc is toxic to neurons and trophic for astrocytes. In our study, paraffin sections from scrapie infected (263K and 139H) and control hamsters were examined with histological and im...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00833-6
更新日期:1998-11-02 00:00:00
abstract::A newly discovered cell-to-cell communication system involves small, membrane-enveloped nanovesicles, called exosomes. We describe here how these extracellular nanoparticles were discovered and how it became gradually apparent that they play fundamental roles in regulation of physiological functions and pathological p...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.09.070
更新日期:2015-08-18 00:00:00
abstract::alpha-Bungarotoxin (alpha-BuTX) binds in a saturable and practically irreversible fashion to membrane-associated receptors in the ciliary ganglion of the adult chick. The binding of toxin to receptors is competitively inhibited by nicotinic cholinergic ligands, and for these properties the receptors are regarded as ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)91130-7
更新日期:1978-09-15 00:00:00
abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor are members of the endogenous opioid peptide family. In mammals N/OFQ modulates a variety of biological functions such as nociception, food intake, endocrine, control of neurotransmitter release, among others. In the molluscs Cepea nemoralis and Helix as...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.02.007
更新日期:2013-04-10 00:00:00
abstract::Transplantation of olfactory ensheathing cells (OECs) into injured spinal cord results in improved functional outcome. Mechanisms suggested to account for this functional improvement include axonal regeneration, remyelination and neuroprotection. OECs transplanted into transected peripheral nerve have been shown to mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.089
更新日期:2006-12-13 00:00:00
abstract::In this study, the effects of early vs. delayed tPA treatment on the development of hemorrhagic transformation was compared in a rat thromboembolic model of stroke. Fibrinolysis was performed by administering tPA intravenously at 2 or 6 h after ischemic onset. Twenty-four hours later, confluent hemorrhagic infarction ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02276-3
更新日期:2000-01-31 00:00:00
abstract::The origin of descending pathways to thoracic and cervical levels of the spinal cord has been investigated with retrograde tracing techniques in a series of pouch young and adult opossums. The opossum was chosen because it is born in a very immature state, 12-13 days after conception, and has a protracted development ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90102-0
更新日期:1984-08-01 00:00:00
abstract::Calcium currents were studied in morphologically identified pyramidal and stellate neurons acutely isolated from layer II/III of rat entorhinal cortex, using the whole-cell patch-clamp configuration. The peak amplitude of high-voltage activated current (HVA) measured at +10 mV was not different in both neuron populati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01234-7
更新日期:1999-01-23 00:00:00
abstract::The postnatal development of cat triceps surae gamma-motoneurones, retrogradely labelled with horseradish peroxidase (HRP), was studied light and electron microscopically. The mean diameter of the cell bodies of the gamma-motoneurones increased by about 25% from birth to the adult stage, which was much less than the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90251-3
更新日期:1987-12-15 00:00:00
abstract::Systemic endothelin-1 (ET-1) enhances the activity of subfornical organ (SFO) neurons with identified projections to the paraventricular nucleus of the hypothalamus (PVN). The present electrophysiological experiments were undertaken to examine the mechanisms through which systemic ET influences vasopressin secretion. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91378-r
更新日期:1992-07-17 00:00:00
abstract::Small reductions in temperature have been shown to improve neurologic recovery after ischemia. We have examined the effect of temperature on biochemical and physiological changes during hypoxia using rat hippocampal slices as a model system. The postsynaptic population spike recorded from the CA1 pyramidal cell region...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01944-7
更新日期:1999-10-09 00:00:00
abstract::The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium om...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02553-7
更新日期:2001-07-06 00:00:00
abstract::In the vertebrate retina excitatory transmission seems to be mediated mainly by excitatory amino acids; glutamate and/or aspartate are the most viable candidates to subserve this function. Postsynaptic receptors for N-methyl-D-aspartate (NMDA), kainate (KA), quisqualate (QA) and 2-amino-4-phosphonobutyric acid have be...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91330-8
更新日期:1987-06-23 00:00:00
abstract::The present study examined the role of the sympathetic nervous system as a mediator of the message from the CNS to the kidneys to stimulate the secretion of renin. Two procedures that increase the secretion of renin were tested: administration of the serotonin releaser fenfluramine, which increases renin release witho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00891-s
更新日期:1995-11-06 00:00:00
abstract::The present paper addresses the question of whether a decline of central noradrenergic activity is associated with aging and memory loss in mice. Receptor binding techniques were utilized to compare alpha 2-adrenoceptor density in the brains of aged and young mice. Using [3H]rauwolscine, a selective alpha 2-adrenocept...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91439-8
更新日期:1985-12-16 00:00:00
abstract::We investigated the effects of pituitary adenylate cyclase-activating polypeptide (PACAP38) on cytosolic free calcium ([Ca2+]i) at a single cell level in both type-1 and type-2 cultured rat astrocytes using a calcium-sensitive fluorescent dye, fura-2. Type-1 astrocytes were relatively silent during the 20 min observat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90790-0
更新日期:1994-10-31 00:00:00
abstract::Active substance P binding sites were solubilized from rat brain membranes by treatment with 0.125% sodium glycodeoxycholate and 1 M NaCl. About 50% of the binding activity in membrane-bound binding sites was recovered in the solubilized fraction after centrifugation at 105,000 g for 1 h. [3H]Substance P absorbed exte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91122-4
更新日期:1986-04-02 00:00:00
abstract::A combination of electron microscopic autoradiography and immunocytochemistry was used to examine the connections between serotoninergic axons and dopaminergic neurons of the arcuate nucleus of the rat hypothalamus. The serotoninergic elements were identified after selective uptake of tritiated serotonin and the dopam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90841-3
更新日期:1986-02-05 00:00:00
abstract::The quantitative autoradiographic method with L-(35S)methionine was used to determine the effects of 1-acute (4h) and 2-chronic (14 days) immobilization stress followed by one week of recovery. Acute stress induced a significant decrease in methionine incorporation into proteins in 17 of the 35 brain structures examin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00046-s
更新日期:1995-03-27 00:00:00
abstract::Stroke is the third leading cause of death in the US, with a prevalence of 750,000 patients per year, and a social cost estimated at $50 billion. Current therapeutics are targeted at restoring blood flow rather than on preventing the actual mechanisms associated with neuronal cell death. Here, we show that, following ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02922-0
更新日期:2002-08-30 00:00:00
abstract::Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00822-8
更新日期:1995-10-02 00:00:00
abstract::Single unit discharges in the superior secondary gustatory nucleus of the carp, Cyprinus carpio L., were studied electrophysiologically in response to chemical stimulation of the external chemoreceptors of the facial skin surface. Of 36 gustatory neurons recorded, 80.6% were facilitated by taste stimuli and 19.4% were...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90184-0
更新日期:1981-07-27 00:00:00