Abstract：
:This study used microdialysis to measure changes in extracellular acetylcholine (ACh) content in the nucleus accumbens (NAC) of freely moving rats during acute and chronic morphine treatment, and following naloxone-precipitated withdrawal. Morphine injection (20 mg/kg, i.p.) caused a significant decrease in extracellular ACh which was not apparent after repeated exposure to the opiate for 7 days. Basal recovery of ACh was not altered by chronic morphine treatment. On day 8, after morphine dependence had been established, naloxone caused a large increase in ACh levels accompanied by withdrawal symptoms such as wet dog shakes, diarrhea and teeth-chattering. Pretreatment with clonidine (200 micrograms/kg, i.p.) reduced these withdrawal symptoms and eliminated the ACh response. These results suggest that accumbens ACh is involved in some of the aversive aspects of opiate withdrawal.
journal_name
Brain Resjournal_title
Brain researchauthors
Rada P,Pothos E,Mark GP,Hoebel BGdoi
10.1016/0006-8993(91)91616-9subject
Has Abstractpub_date
1991-10-11 00:00:00pages
354-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91616-9journal_volume
561pub_type
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