Abstract：
:The specific binding of [3H]neurotensin binding to the rat striatum was characterized and its localization investigated by using frontal cortex ablations and the neurotoxins kainic acid and 6-hydroxydopamine. Scatchard analysis indicated the existence of a single population of binding sites and the potencies of various neurotensin fragments in competing with [3H]neurotensin for its binding site were in good agreement with the potency values obtained in biological assays. The lesion studies indicated that more than 50% of striatal neurotensin receptors are localized on intrinsic neurones, approximately 30% on dopaminergic nerve terminals and 20% on corticostriatal nerve fibres.
journal_name
Brain Resjournal_title
Brain researchauthors
Goedert M,Pittaway K,Emson PCdoi
10.1016/0006-8993(84)90801-1subject
Has Abstractpub_date
1984-05-07 00:00:00pages
164-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90801-1journal_volume
299pub_type
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