Abstract:
:In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were other portions of the hippocampus and amygdala, the head of the caudate nucleus, putamen, hypothalamus, insular cortex, prefrontal cortex, parietal, frontal and temporal cortex, anterior, medial and posterolateral nuclei of the thalamus. Lowest densities, hardly above background, were found in the two divisions of the globus pallidus, the centromedian, ventrolateral and posteroventral lateral nuclei of the thalamus, substantia nigra, red nucleus and white matter. Specific high-affinity [3H]DMI binding was not affected by age, sex and suicide in any of the regions studied. It was negatively correlated with postmortem delay in several regions.
journal_name
Brain Resjournal_title
Brain researchauthors
Gross-Isseroff R,Israeli M,Biegon Adoi
10.1016/0006-8993(88)90353-8subject
Has Abstractpub_date
1988-07-19 00:00:00pages
120-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90353-8journal_volume
456pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.025
更新日期:2009-01-16 00:00:00
abstract::An analysis of cellular kinetics during closure of the cranial neural folds in the C57BL mouse at 8 and 9 days gestations was obtained by means of tritiated thymidine autoradiography. At 8 days the short generation time (7.5 h) and high labeling index (61.4%) are evidence of intensive proliferative activity occurring ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(81)90049-3
更新日期:1981-10-01 00:00:00
abstract::The modulation of serotonin (5-HT) release by opioid receptors in the hippocampus of the awake, unrestrained rat was evaluated by use of in vivo microdialysis. The hippocampus was perfused with Ringer's solution (2 microliters/min), and extracellular levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90456-w
更新日期:1993-06-04 00:00:00
abstract::Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02462-3
更新日期:2001-06-22 00:00:00
abstract::Brain-derived angiotensin II (ANG II) and prostaglandins have important roles in the regulation of body fluid and blood pressure homeostasis. In the present studies we investigated the central interactions between these two neurochemical products in regulating the hypothalamo-neurohypophysial system during dehydration...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03113-9
更新日期:2001-01-19 00:00:00
abstract::The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90112-2
更新日期:1975-09-23 00:00:00
abstract::Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8-12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00329-1
更新日期:1998-06-08 00:00:00
abstract::The serotonin agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected systemically or directly into the medial preoptic area (MPOA), reduces the ejaculatory threshold in male rats. While 8-OH-DPAT has been characterized as an agonist at the 5-HT1A receptor, it also acts at other receptor sites including the dop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01331-6
更新日期:1999-02-27 00:00:00
abstract::Recently it has been reported that prolactin (PRL) exerts a neuroprotective effect against excitotoxicity in hippocampus in the rat in vivo models. However, the exact mechanism by which PRL mediates this effect is not completely understood. The aim of our study was to assess whether prolactin exerts neuroprotection ag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.02.011
更新日期:2016-04-01 00:00:00
abstract::The effects of pituitary adenylate cyclase activating polypeptides (PACAPs: PACAP27, PACAP38) on glutamate-induced neurotoxicity were examined using cultured retinal neurons obtained from 3- to 5-day old Wistar rats. Cell viability was evaluated by double staining with fluorescein diacetate and propidium iodide. Effec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01690-x
更新日期:1999-08-21 00:00:00
abstract::The role of the substantia innominata (SI) in the generation of a behavior mediated by the prefrontal (PF) cortex was examined in two Japanese monkeys. PF neuronal activities related to a visual tracking task by wrist movement were recorded and neural responses to SI stimulation were analyzed. Sixty-six neurons showed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90734-5
更新日期:1983-10-16 00:00:00
abstract::Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.051
更新日期:2014-11-24 00:00:00
abstract::Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other region...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90667-0
更新日期:1986-01-15 00:00:00
abstract::Mild cognitive impairment (MCI) is considered the transitional stage between normal cognition and dementia. The aim of this study was to use tractography based analysis to elucidate alterations in subjects with MCI compared with subjects with early Alzheimer's disease (AD) and controls. Seventeen subjects with early A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.052
更新日期:2009-09-01 00:00:00
abstract::In this study intracellular recording techniques were used to study the synaptic events related to phase-locking of cochlear nucleus cells to low frequency stimuli. A variable degree of phase-locking was noted even with units of the same low characteristic frequency. With low frequency phase-locking units an excitator...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90286-9
更新日期:1976-08-13 00:00:00
abstract::Parvalbumin (PV)-immunoreactive neurons in rat neostriatum were studied under light and electron microscopes. A small number of neurons in the striatum were immunoreactive for PV (a Ca-binding protein). Most of them were also strongly immunoreactive for glutamate decarboxylase but were negative for NADPH-diaphorase ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90002-s
更新日期:1990-12-17 00:00:00
abstract::Starvation inhibits egg-laying in the snail, Lymnaea stagnalis. In starved animals the neurosecretory Caudo-Dorsal Cells (CDC), which produce the egg-laying hormone, are hyperpolarized as compared to the CDC of controls. However, they are more responsive to repetitive intracellular stimulation, which induces the hormo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90528-5
更新日期:1982-05-13 00:00:00
abstract::The developmental and age-related changes of the dopamine transporter (DAT), and the dopamine D1 and D2 receptor (D1R and D2R) subtypes were investigated in basal ganglia (BG) of human brain. DAT immunostaining was mainly observed in the neuropil, neurons, and glia of the striatum. The DAT-positive neuropil was detect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01933-2
更新日期:1999-10-02 00:00:00
abstract::To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90214-6
更新日期:1981-09-07 00:00:00
abstract::The aim of this study was to examine: (1) whether long-term potentiation (LTP) can be induced in slices from adult rat visual cortex under conditions where inhibition is not antagonized, and (2) the role of N-methyl-D-aspartate (NMDA) receptors in its induction. The field potential elicited in layer III in response to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90891-c
更新日期:1992-07-03 00:00:00
abstract::Oxidative stress plays an important role in the pathogenesis of neurodegeneration after the acute central nervous system injury. We reported previously that increased nitric oxide (NO) production following spinal cord hemisection tends to lead to neurodegeneration in neurons of the nucleus dorsalis (ND) that normally ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.003
更新日期:2005-09-07 00:00:00
abstract::We investigated the effect of repetitive transcranial magnetic stimulation (rTMS) on long-term potentiation (LTP) in the rat hippocampus. Rats were magnetically stimulated at a rate of 1000 pulses/day for 7 days by a round coil, in which the peak magnetic fields at the center of the coil were 0.75 and 1.00 T. LTP enha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.009
更新日期:2003-12-12 00:00:00
abstract:BACKGROUND:Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction. AIM:To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146519
更新日期:2020-01-01 00:00:00
abstract::Intracellular staining with recording micropipettes filled with a Procion yellow solution was attempted on 11 lateral geniculate neurons of chloralose-anesthetized cats for the purpose of correlating electrophysiologically identified cell types with morphologically identified cell types. Five neurons were successfully...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90058-6
更新日期:1978-01-06 00:00:00
abstract::Although Rolling mouse Nagoya (RMN) has been considered to demonstrate cerebellar dysfunction, our previous metabolic and electrophysiological studies also revealed a dysfunction of the basal ganglia, with the presumable primary site of dysfunction being the striatum. In the present study, we investigated the neuroche...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01577-9
更新日期:1996-04-01 00:00:00
abstract::Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02585-x
更新日期:2003-06-27 00:00:00
abstract::Motoneurons in the lumbar spinal cord of chick embryos 6 days old, the age when their cell death starts, were labeled in vivo by retrograde axonal transport of horseradish peroxidase (HRP) and then cultured as cord fragments or isolated cells. In Eagle's minimum essential medium with no additives, spinal cord cells su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90037-8
更新日期:1983-09-01 00:00:00
abstract::The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activationa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.035
更新日期:2012-06-15 00:00:00
abstract::Event-related brain potentials were used to study the neural mechanisms underlying goal-directed object use distinguishing between processes supporting immediate and final action goals during action planning and execution. Subjects performed a grasping and transportation task in which actions were cued either with the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.085
更新日期:2007-05-07 00:00:00
abstract::The effects of morphine sulfate and two benzodiazepine derivatives, chlordiazepoxide HCl and diazepam, were evaluated upon single unit activity of the amygdaloid nuclear complex and hippocampal formation in immobilized cats. All surgical procedures were performed under halothane anesthesia and all wound margins were i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90595-9
更新日期:1977-05-13 00:00:00