Abstract：
:Stimulation frequency thresholds for lateral hypothalamic self-stimulation were monitored for 3 weeks following the induction of diabetes with streptozotocin (STZ). In each of the 3 weeks following STZ treatment, thresholds of diabetic rats were significantly lower than their pre-STZ baseline while thresholds of control animals did not change. Naltrexone (5.0 mg/kg, s.c.) increased thresholds of diabetic rats while having no effect on thresholds of control rats. These results suggest that STZ-induced diabetes is associated with an opioid-mediated lowering of self-stimulation threshold. The possible relationship between this finding and similar findings obtained in food-restricted animals is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Carr KDdoi
10.1016/0006-8993(94)91973-9subject
Has Abstractpub_date
1994-11-21 00:00:00pages
211-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91973-9journal_volume
664pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Paranodal glial loops (lateral belt cytoplasm) of myelinated CNS and PNS fibres contain tubules of agranular reticulum, as well as microtubules, wound spirally around the axon. Similar agranular elements run circumferentially in the expanded rims of sheet-like astrocytic processes encapsulating thalamic synaptic glome...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90414-x
更新日期：1980-09-08 00:00:00
abstract：:Endogenous cytochrome oxidase activity within the mitochondria of neurons and neuropil was demonstrated histochemically under normal and experimental conditions. Since enzymatic changes were noted with chronic neuronal inactivity in the auditory system (Wong-Riley et al), the present study sought to examine functional...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90728-5
更新日期：1979-07-27 00:00:00
abstract：:Many AIDS patients suffer from cognitive impairments including deficits in learning and memory. The Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein gp120 is one possible mediator of these impairments. This is because gp120 activates brain microglial cells and astrocytes, and in vivo activation of glia lea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02445-2
更新日期：2000-04-07 00:00:00
abstract：:Nerve fibers and their axon terminals with substance P (SP)-like and calcitonin gene-related peptide (CGRP)-like immunoreactivity in the nucleus tractus solitarii were ultrastructurally characterized by a combination of immunofluorescent double staining and the PAP method. The axon terminals formed asymmetrical synapt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90269-6
更新日期：1986-07-30 00:00:00
abstract：:The concentration of soluble glial fibrillary acidic (GFA) protein and the specific activity of glutamine synthetase (GS) were estimated in 11 central nervous system (CNS) regions of the 90-day-old rat. Marked differences were observed in the regional distribution of these astrocyte marker proteins. The striatum and s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90708-5
更新日期：1985-04-01 00:00:00
abstract：:To study the regulation of hypothalamic vasopressin (VP) and oxytocin (OT) gene expression in relation to the development of hypertension, levels of VP mRNA and OT mRNA were determined in spontaneously hypertensive rats (SHR). Differences in VP and OT mRNA content of the supraoptic nucleus (SON) and paraventricular nu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90039-3
更新日期：1988-12-01 00:00:00
abstract：:In order to establish possible stimulatory effects of increasing plasma concentrations of substance P (SP) on the arginine vasopressin (AVP) and/or oxytocin (OT) secretion, successively increasing doses of SP(0.5, 1 and 1.5 pmol/kg-1/min-1; each dose for 20 min) were infused in 7 normal men. Plasma AVP and OT levels w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90387-o
更新日期：1992-01-08 00:00:00
abstract：:Mesencephalic dopamine neurons form synapses with acetylcholine (ACh)-containing interneurons in the nucleus accumbens (NAcc). Although their involvement in drug reward has not been systematically investigated, these large aspiny interneurons may serve an important integrative function. We previously found that repeat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.029
更新日期：2006-12-06 00:00:00
abstract：:Corticosterone influences emotion and cognition via actions in a diversity of corticolimbic structures, including the amygdala. Since extracellular levels of corticosterone in brain have rarely been studied, we characterized a specific and sensitive enzymatic immunoassay for microdialysis quantification of corticoster...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.01.010
更新日期：2012-05-03 00:00:00
abstract：:Angiotensin peptides are thought to act as neurotransmitters or neuromodulators in central osmoregulation. We tested the hypothesis that angiotensin peptides are released in the paraventricular nucleus (PVN) of the hypothalamus upon local osmotic stimulation. Brain microdialysis and radioimmunoassay (RIA) techniques w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91215-7
更新日期：1994-02-21 00:00:00
abstract：:Individual vulnerability to the reinforcing effects of drugs appear to be a crucial factor in the development of addiction in humans. In the rat, individuals at risk for psychostimulant self-administration (SA) may be identified from their locomotor reactivity to a stress situation such as exposure to a novel environm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91452-7
更新日期：1991-12-13 00:00:00
abstract：:Studies of first (L1) and second (L2) language representation in the brain have not identified the timing and locations of neural regions involved in L1 and L2 processing. Magnetoencephalography offers high spatial and temporal resolution and can be employed to disentangle subtle timing and neural control differences ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.05.054
更新日期：2012-07-27 00:00:00
abstract：:The actions of pentobarbital (PB) and diphenylhydantoin (DPH) have been studied on neurons of dorsal root ganglia from adult rats. At anesthetic level (i.e. 1--2 x 10(-4) M), PB greatly enhanced neuronal responses to gamma-aminobutyric acid (GABA); at 10(-3) M PB caused a small depolarization and profoundly attenuated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90370-x
更新日期：1981-03-02 00:00:00
abstract：:The objective of this study was to assess the influence of Ca2+ influx on intracellular pH (pHi) of neocortical neurons in primary culture. Neurons were exposed to glutamate (100-500 microM) or KCl (50 mM), and pHi was recorded with microspectrofluorometric techniques. Additional experiments were carried out in which ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00056-v
更新日期：1995-04-10 00:00:00
abstract：:Behavioral stress is likely to contribute to the development of hypertension in susceptible individuals. We reported that hemodynamic response patterns to acute startle vary and that those patterns predict the predisposition of rats to sustained stress-induced elevations in arterial pressure. Since considerable eviden...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02226-1
更新日期：2003-04-04 00:00:00
abstract：:Invasion of scrapie agent into the central nervous system (CNS) was studied in rats following intracerebral and peripheral inoculation, the latter by injection into intact or transected sciatic nerve. Comparison of sleep-wakefulness alterations, neuropathological features, and time lag of electroencephalographic and c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90048-x
更新日期：1986-09-24 00:00:00
abstract：:Using the rapid Golgi method, the morphology of dendritic spines was quantified in the calyxes of groups of newly emerged, nurse, and forager honeybees. These groups were studied because they represented distinct stages of behavioral development and cumulative experience which, according to recent vertebrate findings,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91007-0
更新日期：1980-06-16 00:00:00
abstract：:While exercise is commonly recommended for PD patients to improve motor function, little is known about the disease-altering potential of exercise. Although others have demonstrated neuroprotective or neurorestorative effects of exercise in animal models of PD, the majority of these studies utilize young animals. In o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.06.032
更新日期：2016-09-01 00:00:00
abstract：:Intracerebral injections of 6-hydroxydopamine (6-OHDA) which produce deficits in locomotor behaviour and motor performance cause localized accumulation of monoamines as well as depletion of central catecholamines (CA). To determine whether the localized increases in monoamines could be contributing to the behavioural ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90659-5
更新日期：1983-05-05 00:00:00
abstract：:Diffusion patterns of 14C-labeled penicillin, resulting from microinjections into different neocortical laminae, were compared with simultaneous electrophysiologic monitoring of epileptogenesis across these laminae. Injections into layer IV produced response alterations quickly in all recorded layers even with penicil...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90957-0
更新日期：1984-01-09 00:00:00
abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.023
更新日期：2015-06-22 00:00:00
abstract：:Extracellular recordings from 141 rat supraoptic nucleus neurons maintained in vitro in a perfused hypothalamic explant indicated that the excitability of 85% of cells was enhanced by the addition of 10-200 microM norepinephrine (NE) and the alpha-agonist methoxamine (MOXY), but not by isoproterenol, to the perfusion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90499-2
更新日期：1984-07-30 00:00:00
abstract：:Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.05.029
更新日期：2014-07-21 00:00:00
abstract：:The effect of potassium depolarization on dopamine D1 receptor activity in bovine retina was investigated. Preincubation of bovine retinas in buffer containing high KCl (56 mM) as compared to a low KCl control buffer resulted in a significant decrease in dopamine-stimulated adenylate cyclase activity with no change in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91555-u
更新日期：1990-06-25 00:00:00
abstract：:Lesions to the ventromedial hypothalamus (VMH) inhibit receptive sexual behavior in the whiptail lizard, Cnemidophorus uniparens, an all-female species. All lesions to the VMH that effectively abolished receptivity specifically damaged the dorsal lateral VMH, an area containing high concentrations of estrogen receptor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00191-r
更新日期：1995-05-22 00:00:00
abstract：:A double-labeling immunofluorescence technique was employed to investigate the co-localization of the functionally antagonistic neuropeptides, substance P and enkephalins, within intraspinal neurons of the rat. Anti-Met-enkephalin-Arg6-Gly7-Leu8 (Enk-8) antiserum was used as a marker of the preproenkephalin A neuron s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90148-5
更新日期：1988-06-21 00:00:00
abstract：:Angiotensin converting enzyme (ACE) is Zn2+ metallopeptidase which plays an important role in blood pressure homeostasis in mammals and other vertebrates. Homologues of ACE involved in the biosynthesis of mammalian peptide hormones have also been identified in the insects, Musca domestica, Drosophila melanogaster and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01398-x
更新日期：1998-03-02 00:00:00
abstract：:Cytosolic enzymes AMP deaminase and adenosine deaminase (ADA) catalyze AMP and adenosine deamination, constitute rate-limiting steps of adenine nucleotide catabolism and play important roles in cellular energy metabolism. In this study, AMP deaminase and ADA activities of rat liver, neocortex, cerebellum, striatum and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.073
更新日期：2010-01-22 00:00:00
abstract：:Hippocampal cholinergic neurons are sensitive to acute ethanol administration, and specific alterations are seen in the functioning of these neurons following chronic ethanol. The present study examined the effects of chronic ethanol exposure and withdrawal on the sensitivity of the hippocampus to local injection of p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90500-1
更新日期：1985-06-03 00:00:00
abstract：:A direct projection from rat mesencephalic trigeminal nucleus (Vme) neurons to the hypoglossal nucleus (XII) motoneurons was studied using a double labeling method of anterogradely biotinylated dextran amine (BDA) tracing combined with retrogradely horseradish peroxidase (HRP) transport at both light and electron micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02911-0
更新日期：2001-10-26 00:00:00
