An MEG study of the spatiotemporal dynamics of bilingual verb generation.

Abstract:

:Studies of first (L1) and second (L2) language representation in the brain have not identified the timing and locations of neural regions involved in L1 and L2 processing. Magnetoencephalography offers high spatial and temporal resolution and can be employed to disentangle subtle timing and neural control differences between L1 and L2 use. We tested bilingual adults in the MEG as they completed a picture verb generation task in L1 and L2. We found the expected progression of activation from occipital to temporal to inferior frontal areas. We also observed the following differences. A sustained insula and early cingulate event-related desynchrony was observed only with L2; the fMRI literature suggests that the former reflects an activation, and the latter an inhibition, sub-process for language selection. L2 processes exhibited a lag and were bilateral compared to L1 processes. Finally, L1 and L2 activated adjacent language control in dorsolateral pre-frontal cortex.

journal_name

Brain Res

journal_title

Brain research

authors

Pang EW,MacDonald MJ

doi

10.1016/j.brainres.2012.05.054

subject

Has Abstract

pub_date

2012-07-27 00:00:00

pages

56-66

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(12)00987-0

journal_volume

1467

pub_type

杂志文章
  • Vasopressinergic neurons in the magnocellular nuclei of the human basal forebrain.

    abstract::Vasopressinergic structures were examined within the magnocellular nuclei of the human basal forebrain. Vasopressinergic neurons were found in all parts of the diagonal band nucleus, and less frequently in the anteromedial subnucleus of the basal nucleus (Meynert). They belong to the group of large multipolar neurons,...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90678-5

    authors: Ulfig N,Braak E,Ohm TG,Pool CW

    更新日期:1990-10-15 00:00:00

  • Reserpine attenuates D-amphetamine and MDMA-induced transmitter release in vivo: a consideration of dose, core temperature and dopamine synthesis.

    abstract::Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00720-3

    authors: Sabol KE,Seiden LS

    更新日期:1998-09-21 00:00:00

  • Spinal antinociceptive action of three representative opioid peptides in frogs.

    abstract::Spinal administration of low doses of dynorphin, beta-endorphin or Met-enkephalin produces a potent, dose-dependent increase in the nociceptive threshold in the unanesthetized frog, Rana pipiens. Nociceptive thresholds were determined by using the acetic acid test, previously shown to be a sensitive indicator of antin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91069-9

    authors: Stevens CW,Pezalla PD,Yaksh TL

    更新日期:1987-01-27 00:00:00

  • Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist.

    abstract::Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90991-4

    authors: Dougherty PM,Willis WD

    更新日期:1991-02-22 00:00:00

  • Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat.

    abstract::Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)01461-p

    authors: Godbout R,Jelenic P,Labrie C,Schmitt M,Bourguignon JJ

    更新日期:1995-02-27 00:00:00

  • Role of protein phosphatases in the modulation of neuronal membrane currents.

    abstract::Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90611-x

    authors: Ichinose M,Byrne JH

    更新日期:1991-05-17 00:00:00

  • Editorial: Mechanistic underpinnings of stem cell therapy for neurological disorders.

    abstract::This special issue entitled "Mechanistic underpinnings of stem cell therapy for neurological disorders" brings together academicians, clinicians and industry partners with vested interest in the safe and effective translation of stem cell-based therapeutics from the laboratory to the clinic. Despite the scientific adv...

    journal_title:Brain research

    pub_type: 社论

    doi:10.1016/j.brainres.2019.146643

    authors: Bonsack B,Kingsbury C,Brown J,Borlongan CV

    更新日期:2020-02-15 00:00:00

  • Amyloid beta-protein stimulates casein kinase I and casein kinase II activities.

    abstract::Amyloid beta-protein (A beta) is the major protein of cerebrovascular and plaque amyloid in Alzheimer's disease (AD). Extensive evidence has demonstrated abnormal protein phosphorylation in this disease. We investigated the effect of synthetic A beta with the amino-acid sequence corresponding to cerebrovascular A beta...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90479-7

    authors: Chauhan A,Chauhan VP,Murakami N,Brockerhoff H,Wisniewski HM

    更新日期:1993-11-26 00:00:00

  • Comparison processes in category learning: from theory to behavior.

    abstract::Recent studies stressed the importance of comparing exemplars both for improving performance by artificial classifiers as well as for explaining human category-learning strategies. In this report we provide a theoretical analysis for the usability of exemplar comparison for category-learning. We distinguish between tw...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.04.079

    authors: Hammer R,Bar-Hillel A,Hertz T,Weinshall D,Hochstein S

    更新日期:2008-08-15 00:00:00

  • Effect of MK-801 on the induction and subsequent decay of long-term potentiation in the unanesthetized rabbit hippocampal dentate gyrus.

    abstract::Several investigations have shown that the N-methyl-D-aspartate (NMDA) antagonist MK-801 interferes both with learning and a candidate neural mechanism for learning, the long-term potentiation (LTP) phenomenon. The low doses of MK-801 reported to block learning, however, may not be sufficient to block LTP. The present...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90371-f

    authors: Robinson GB,Reed GD

    更新日期:1992-01-08 00:00:00

  • Quantification of the effects of long-term unilateral naris closure on the olfactory bulbs of adult mice.

    abstract::The effects of unilateral naris closure on the olfactory bulbs of adult mice were assessed quantitatively by measuring four parameters. Naris closures were performed when animals were at least 5 months of age and lasted for 4-8 months. The first parameter measured was mitral cell number, which revealed that there was ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91402-m

    authors: Henegar JR,Maruniak JA

    更新日期:1991-12-24 00:00:00

  • Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons.

    abstract::Polyamines play critical roles during the development of brain neurons. In the present study we examined the effects of polyamines on neuronal apoptotic death. Rat cerebellar granule neurons were cultured in the presence of a depolarizing concentration of KCl (25 mM) in the medium. Apoptotic neuronal death was induced...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00011-5

    authors: Harada J,Sugimoto M

    更新日期:1997-04-11 00:00:00

  • Different effects of calcium flux-blocking agents on light and potassium stimulated release of taurine from retina.

    abstract::Conditions for the stimulation of taurine release by illumination or increased K+ concentrations were established. The effect of Mg2+, ruthenium red and verapamil on taurine release induced by both procedures was compared. All these agents antagonize Ca2+-dependent release of neurotransmitters. Illumination-induced re...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90054-8

    authors: López-Colomé A,Erlij D,Pasantes-Morales H

    更新日期:1976-09-03 00:00:00

  • Convergence of somatosensory and baroreceptive inputs onto parabrachio-subfornical organ neurons in the rat: an electrophysiological study.

    abstract::Electrophysiological characteristics were described for neurons of the parabrachial nucleus (PBN) which receive baroreceptive and somatosensory inputs in the rat. Following focal electrical stimulation in the ipsilateral caudal nucleus of the tractus solitarii (NTS), the firing rates of these neurons were increased in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91704-5

    authors: Han ZS,Gu GB,Sun CQ,Ju G

    更新日期:1991-12-06 00:00:00

  • Differences in AMPA and GABAA/B receptor subunit expression between the chronically reorganized cortex and brainstem of adult squirrel monkeys.

    abstract::The primate somatosensory neuraxis provides a highly translational model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for AMPA and GABAA/B receptor subunits of area 3b cortex and cuneate nucleus of adult squirrel monkeys one to five years after median and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.03.010

    authors: Mowery TM,Sarin RM,Kostylev PV,Garraghty PE

    更新日期:2015-06-22 00:00:00

  • Brainstem command systems for locomotion in the lamprey: localization of descending pathways in the spinal cord.

    abstract::The lamprey brainstem contains a 'command system' which descends into the spinal cord to activate motor networks and initiate locomotion. In the present study, partial lesions were made in the rostral spinal cord in order to spare various tracts and determine which tracts carry the descending command signal to the spi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90704-4

    authors: McClellan AD

    更新日期:1988-08-09 00:00:00

  • Growth hormone increases somatostatin release and messenger ribonucleic acid levels in the rat hypothalamus.

    abstract::Growth hormone (GH) suppresses its own secretion by stimulating somatostatin (SRIF) release. Thus, the possible regulation of GH-releasing factor (GRF) and SRIF release and SRIF messenger ribonucleic acid (mRNA) by GH was studied in the hypothalamus of male rats in vitro. The median eminences (ME's) were incubated in ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90014-e

    authors: Aguila MC,McCann SM

    更新日期:1993-09-24 00:00:00

  • Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's disease.

    abstract::Fluoro-Jade B is known as a high affinity fluorescent marker for the localization of neuronal degeneration during acute neuronal distress. However, one study suggested that fluoro-Jade B stains reactive astroglia in the primate cerebral cortex. In this study, we analyzed the staining of fluoro-Jade B alone or combined...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.05.050

    authors: Damjanac M,Rioux Bilan A,Barrier L,Pontcharraud R,Anne C,Hugon J,Page G

    更新日期:2007-01-12 00:00:00

  • Gene expression in the presence or absence of myelin assembly.

    abstract::Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(87)90021-0

    authors: LeBlanc AC,Poduslo JF,Mezei C

    更新日期:1987-04-01 00:00:00

  • Sex difference in Onuf's nucleus homologue in the Asian musk shrew.

    abstract::Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.05.056

    authors: Polak K,Freeman LM

    更新日期:2010-07-30 00:00:00

  • Stability of cell size and nucleolar size in tangle-bearing neurons of the hippocampus in Alzheimer's disease.

    abstract::Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interacti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90843-3

    authors: Gertz HJ,Schoknecht G,Krüger H,Cervos-Navarro J

    更新日期:1989-05-22 00:00:00

  • Morphine tolerance and dependence in the nucleus paragigantocellularis: single unit recording study in vivo.

    abstract::In this study, a single unit activity was recorded in the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla of anesthetized, morphine-dependent rats. The spontaneous activity of PGi neurons was significantly decreased by administration of morphine (10 mg/kg; i.p.) in sham-operated, cont...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01029-4

    authors: Haghparast A,Semnanian S,Fathollahi Y

    更新日期:1998-12-14 00:00:00

  • Proprioceptive control of human wrist extensor motor units during an attention-demanding task.

    abstract::The responsiveness of the tonically firing single motor units (SMU) to Ia afferent volleys elicited by either mechanical (T-reflex) or electrical nerve stimulation (H-reflex) was tested in the extensor carpi radialis muscle (ECR) while the subjects were maintaining a steady wrist extension force using visual feedback ...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.brainres.2004.05.066

    authors: Nafati G,Rossi-Durand C,Schmied A

    更新日期:2004-08-27 00:00:00

  • The influence of aging and hypertension on cerebral autoregulation.

    abstract::Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90454-6

    authors: Hoffman WE,Albrecht RF,Miletich DJ

    更新日期:1981-06-09 00:00:00

  • Retrograde cortical aand axonal changes following lesions of the pyramidal tract.

    abstract::Following lesions of the pyramidal tract in hamsters, retrograde changes were studied in the sensorimotor cortex and in the pyramidal tract axons proximal to the lesion, at survival times ranging from 2 weeks to 14 months. Severe cell shrinkage occurred in layer 5 pyramidal neurons as early as 2 weeks, but there was n...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90130-4

    authors: Kalil K,Schneider GE

    更新日期:1975-05-16 00:00:00

  • Benzodiazepine receptor binding by membranes from brain cell cultures following chronic treatment with diazepam.

    abstract::Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90117-8

    authors: Prezioso PJ,Neale JH

    更新日期:1983-12-12 00:00:00

  • Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons.

    abstract::Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.06.014

    authors: Ciobanu C,Reid G,Babes A

    更新日期:2009-08-11 00:00:00

  • Protection of methamphetamine nigrostriatal toxicity by dietary selenium.

    abstract::Multiple dose administration of methamphetamine (MA) results in long-lasting toxic effects in the nigrostriatal dopaminergic system. These effects are considered to be primarily due to oxidative damage mediated by increased production of hydrogen peroxide or other reactive oxygen species in the dopaminergic system. Th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02122-8

    authors: Kim HC,Jhoo WK,Choi DY,Im DH,Shin EJ,Suh JH,Floyd RA,Bing G

    更新日期:1999-12-18 00:00:00

  • Glutamine transport in cerebellar granule cells in culture.

    abstract::In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00139-x

    authors: Su TZ,Campbell GW,Oxender DL

    更新日期:1997-05-16 00:00:00

  • The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice.

    abstract::The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adeno...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91604-q

    authors: Janusz CA,Berman RF

    更新日期:1993-08-13 00:00:00