Cytokines regulate c-Met expression in cultured astrocytes.

Abstract:

:We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. Reverse transcription-polymerase chain reaction revealed that FGFs and HGF enhanced c-met expression. These findings suggest that c-Met expressed in astrocytes may have important roles during the nervous system regeneration.

journal_name

Brain Res

journal_title

Brain research

authors

Shimazaki K,Yoshida K,Hirose Y,Ishimori H,Katayama M,Kawase T

doi

10.1016/s0006-8993(02)03975-6

subject

Has Abstract

pub_date

2003-02-07 00:00:00

pages

105-10

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006899302039756

journal_volume

962

pub_type

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