Abstract:
:We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. Reverse transcription-polymerase chain reaction revealed that FGFs and HGF enhanced c-met expression. These findings suggest that c-Met expressed in astrocytes may have important roles during the nervous system regeneration.
journal_name
Brain Resjournal_title
Brain researchauthors
Shimazaki K,Yoshida K,Hirose Y,Ishimori H,Katayama M,Kawase Tdoi
10.1016/s0006-8993(02)03975-6subject
Has Abstractpub_date
2003-02-07 00:00:00pages
105-10issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302039756journal_volume
962pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::An enriched environment has been shown to improve cognitive, behavioral and histopathological outcome after focal cerebral ischemia and head trauma. The purpose of this study was to determine the effect of an enriched environment on histopathology following global cerebral ischemia. Wistar rats (21 weeks of age) were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04089-1
更新日期:2003-02-21 00:00:00
abstract::The substantia nigra pars reticulata (SNr) receives both inhibitory GABAergic and excitatory glutamatergic afferents from diverse origins. Ischemic injury to the striatum and/or the globus pallidus causes delayed transneuronal death of the SNr neurons, in the course of which neuronal disinhibition induced by loss of G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01052-9
更新日期:1996-12-16 00:00:00
abstract::After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02793-1
更新日期:2000-10-13 00:00:00
abstract::Experiments have been performed on pentobarbitone anesthetized or decerebrated rats. The nature of the synchronous rhythmical activity which occurs in the inferior olive following the electrophoretic or systemic administration of harmaline, harmine, dihydro-beta-erythroidine and various other compounds, is described. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90471-6
更新日期:1976-01-23 00:00:00
abstract::In extracellular recordings from chloral hydrate anesthetized rats the 5-HT3 antagonist, BRL 46470A, failed to prevent or reverse the increase in dopamine cell firing rate produced by systemic or iontophoretically applied morphine. A second 5-HT3 antagonist, tropesitron, was similarly found to be ineffective in antago...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90665-3
更新日期:1994-02-28 00:00:00
abstract::MPTP is a neurotoxin thought to damage dopaminergic neurons through free radical formation. MPTP is metabolized in the brain to MPP(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. We used striatal synaptosomes and telencephalic mitochondria to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02675-1
更新日期:2003-06-13 00:00:00
abstract::During cerebral ischemia, dysregulated glutamate release activates N-methyl-d-aspartate (NMDA) receptors which promotes excitotoxicity and intracellular acidosis. Ischemia also induces cellular adenosine (ADO) release, which activates ADO receptors and reduces neuronal injury. The aim of this research was to determine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.115
更新日期:2006-04-12 00:00:00
abstract::While genetic predisposition is a major factor, it is not known how development of attention-deficit/hyperactivity disorder (ADHD) is modulated by early life stress. The spontaneously hypertensive rat (SHR) displays the behavioral characteristics of ADHD (poorly sustained attention, impulsivity, hyperactivity) and is ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.11.019
更新日期:2016-06-15 00:00:00
abstract::The effects of the epileptogenic agent, penicillin, on excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) were studied in the hippocampal in vitro slice preparation. The actions of penicillin were compared to those of bicuculline, an antagonist of gamma-aminobutyric acid. Neither substance enhanced mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90119-5
更新日期:1980-02-03 00:00:00
abstract::Photoreceptor outer segments are continually renewed from base to tip and consequently the membrane at the tip is older than at the base. In parallel with this, there are differences in light responsiveness, and it has been proposed that these may be due to the aforementioned differences in age. We have tested this pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01357-1
更新日期:1997-03-07 00:00:00
abstract::The present experiments showed that there is a cortico-thalamo-cortical projection system in the cat, which originates from the primary visual cortex, relayed by the lateral part of the lateral posterior nucleus of the thalamus, and reaching the medial bank of the lateral suprasylvian visual area. This finding suggest...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90323-4
更新日期:1990-02-12 00:00:00
abstract::Acupuncture is widely used to relieve pain; however, the mechanism underlying electroacupuncture analgesia (EAA) during inflammatory pain is unclear. We investigated whether endogenous peripheral opioid receptors participated in EAA during hyperalgesia elicited by carrageenan-induced inflammation. Moreover, we investi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.08.014
更新日期:2010-10-08 00:00:00
abstract::Response conflict can be induced by priming multiple responses competing for control of action in trials. The N2 is one functionally-related cognitive control index for response conflict. And yet the underlying whiter matter neural substrates of inter-individual difference in conflict N2 remain unclear. So the aim of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.09.008
更新日期:2017-12-01 00:00:00
abstract::Trophic effects of neurturin, a member of the glial cell line-derived neurotrophic factor-family, have been demonstrated on mesencephalic dopaminergic neurons, suggesting its therapeutic potential for Parkinson's disease. This study was designed to test the neuroprotective and regenerative effects of an intrastriatal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02934-7
更新日期:2002-08-30 00:00:00
abstract::Morphological changes in neocortical somatostatin- and neuropeptide-Y-immunoreactive cells in senile dementia of the Alzheimer type (SDAT) were studied using light-microscopic immunohistochemical methods. The density of somatostatin-immunoreactive cells in the neocortex did not decrease in cases of SDAT compared with ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91099-1
更新日期:1986-04-02 00:00:00
abstract::Hindpaw injections of carrageenan (CARRA) decreased paw withdrawal latencies to radiant heat and increased hindpaw edema. At the peak of hyperalgesia, the content of immunoreactive guanosine 3',5'-cyclic monophosphate (i-cGMP) was increased, while immunoreactive adenosine 3',5'-cyclic monophosphate (i-cAMP) was decrea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90066-3
更新日期:1994-05-16 00:00:00
abstract::Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.023
更新日期:2018-08-01 00:00:00
abstract::The effects of bilateral intracranial injections of the D-1 dopamine receptor antagonist SCH 23390 HCl (0, 0.8, 1.6, 3.2, and 6.4 microgram total bilateral dose) administered into the dorsolateral bed nucleus of the stria terminalis (dlBNST) immediately prior to a 3 h intravenous cocaine self-administration session we...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01190-6
更新日期:1998-02-16 00:00:00
abstract::mRNA prepared from rat small intestine was injected into Xenopus oocytes. The injected oocytes showed a clear electrical response to D-glucose (Glu) in the form of membrane depolarization and conductance increase, while none was shown to D-fructose. The membrane electrical response of the injected oocytes evoked by Gl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(87)90033-7
更新日期:1987-09-01 00:00:00
abstract::The visual Wulst (VW) in the avian telencephalon is thought to be an avian equivalent of the mammalian striate cortex. Effects of electrical stimulation of VW were studied in the isthmo-optic nucleus (ION) of the Japanese quail by extracellular recording. Most ION neurons examined were activated by VW stimulation, and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90800-6
更新日期:1987-03-17 00:00:00
abstract::Systemic administration of the protein synthesis inhibitor, cycloheximide, induced both phase advances and phase delays in the circadian rhythm of wheel-running activity in hamsters (Mesocricetus auratus) maintained in constant darkness or constant light. The magnitude and direction of the phase shifts were dependent ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91053-6
更新日期:1989-09-04 00:00:00
abstract::The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.058
更新日期:2007-01-12 00:00:00
abstract::Motor-related regions of parietal and prefrontal cortices have been shown to selectively activate when observers passively view objects that afford manual grasping. Yet, it remains unknown whether these cortical responses depend on prior motor-related experience with the object being observed. To address this question...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.059
更新日期:2006-06-30 00:00:00
abstract::The effects of the 8-alpha-amino-ergoline CU 32-085 on central dopamine neuronal systems was investigated. Two h after administration of CU 32-085 a slight increase of dopamine levels was observed in the nucleus caudatus-putamen. Radioligand binding studies in vitro have shown that CU 32-085 has a low affinity for str...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91044-3
更新日期:1985-03-04 00:00:00
abstract::Neuropeptides, including substance P (SP), calcitonin gene-related peptide (CGRP) and somatostatin (SS) in dorsal root ganglia (DRG) may play a role in neurogenic inflammation and pain transmission. Adrenal corticosteroids regulate neuropeptide synthesis in some areas of the CNS and may modulate neurogenic inflammatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91347-4
更新日期:1991-11-08 00:00:00
abstract::Parkinson's Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive imp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.03.035
更新日期:2019-01-01 00:00:00
abstract::Extracellular recordings from 141 rat supraoptic nucleus neurons maintained in vitro in a perfused hypothalamic explant indicated that the excitability of 85% of cells was enhanced by the addition of 10-200 microM norepinephrine (NE) and the alpha-agonist methoxamine (MOXY), but not by isoproterenol, to the perfusion ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90499-2
更新日期:1984-07-30 00:00:00
abstract::The effects of prostaglandin E1 (PGE1) on porcine cerebral arteries were studied in the absence and presence of cyclooxygenase inhibitors, 5 x 10(-6) M indomethacin or 10(-4) M aspirin. In preparations placed at a resting tension, 3 x 10(-9) to 10(-6) M PGE1 caused dose-dependent contractions. In prostaglandin F2 alph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91096-2
更新日期:1989-09-04 00:00:00
abstract::In spite of the numerous reports on the optic fiber distribution in the optic nerve and tract of vertebrates, there have been few studies of the visual pathway in reptiles. The arrangement of fibers in the optic nerve and tract of the turtle Mauremys leprosa was studied by placing a small granule of carbocyanine dye (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.016
更新日期:2007-12-01 00:00:00
abstract::The effect of a dihydropyridine Ca2+ antagonist, cilnidipine, on voltage-dependent Ca2+ channels was studied in acutely dissociated rat CA1 pyramidal neurons using the nystatin-perforated patch recording configuration under voltage-clamp conditions. Cilnidipine had no effect on low-voltage-activated (LVA) Ca2+ channel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02295-7
更新日期:2000-01-31 00:00:00