Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat.

abstract：:The non-toxic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector to enhance delivery of potentially therapeutic proteins to motor neurons from the periphery following an intramuscular injection. The unique binding and transport properties of this 50-kDa polypeptide sugge...

journal_title：Brain research

authors： Francis JW,Bastia E,Matthews CC,Parks DA,Schwarzschild MA,Brown RH Jr,Fishman PS

更新日期：2004-06-11 00:00:00

abstract：:Neonatal MK-801 treatment from postnatal day 8-19 leads to long-term effects on brain function, suggesting that exposure to this drug leads to the development of a brain with immature network properties. One aspect of this hypothesis, that the NMDA receptors preserve their immature state after the treatment, has been ...

journal_title：Brain research

authors： Gorter JA,Brady RJ

更新日期：1994-11-28 00:00:00

abstract：:The duration of the sensitive period of the kitten visual cortex to the effects of monocular deprivation was explored by studies of the behavioral and physiological recovery from extended periods of monocular occlusion imposed from birth, and by examination of the physiological effects of a 3 month period of monocular...

journal_title：Brain research

authors： Cynader M,Timney BN,Mitchell DE

更新日期：1980-06-09 00:00:00

abstract：:Clinically, phenytoin is thought to be useful in controlling seizure activity by preventing it's spread from the focus to neighboring tissue. Experimentally, it has been suggested that phenytoin's principal action is no longer polysynaptic pathways with primary foci affected less than surrounding tissue. In this study...

journal_title：Brain research

authors： Chatt AB,Ebersole JS

更新日期：1984-03-19 00:00:00

abstract：:A study of brains of 16 dogs from one to 19 years of age showed a structure- and cell-type- specific pattern of tau protein phosphorylation at mAb Tau-1 site and the absence of phosphorylation at the mAb AT8 site. Strong immunolabeling with mAb Tau-1 of the mossy fibers and perikarya of neurons in sectors CA3 and CA4 ...

journal_title：Brain research

authors： Wegiel J,Wisniewski HM,Sołtysiak Z

更新日期：1998-08-17 00:00:00

abstract：:We have identified an inhibitory neuron (RPL4) in the right pleural ganglion of Aplysia, which produced hyperpolarization of the sensory and motor neurons involved in the tail withdrawal reflex. Activation of RPL4 significantly reduced the amplitude of excitatory postsynaptic potentials produced in tail motor neurons ...

journal_title：Brain research

authors： Buonomano DV,Cleary LJ,Byrne JH

更新日期：1992-04-10 00:00:00

abstract：:Monkeys made hemiparkinsonian by infusion of a solution of MPTP into one carotid artery appeared to ignore food presented from the contralateral side. Initial observations suggested neglect of visual stimuli presented as fruit treats by automated delivery system in the half-field contralateral to MPTP treatment. Furth...

journal_title：Brain research

authors： Bankiewicz KS,Oldfield EH,Plunkett RJ,Schuette WH,Cogan DG,Hogan N,Zuddas A,Kopin IJ

更新日期：1991-02-08 00:00:00

abstract：:Small injections of two highly sensitive anterograde tracers, Phaseolus vulgaris-leucoagglutinin (PHA-L) and biocytin, into the striatum and the subthalamic nucleus of squirrel monkeys (Saimiri sciureus) have revealed a high degree of convergence of striatal and subthalamic fibers upon single pallidal cells. Both affe...

journal_title：Brain research

authors： Hazrati LN,Parent A

更新日期：1992-01-13 00:00:00

abstract：:Reducing external calcium from 1.0 to 0.1 mM increased the flash sensitivity and the time-to-peak (tp) of linear responses of rod photoreceptors. The quantitative relation between flash sensitivity and tp was the same as during light adaptation. However, the calcium ionophore A23187 reduced sensitivity without affecti...

journal_title：Brain research

authors： Matthews GG

更新日期：1985-04-15 00:00:00

abstract：:Interactions between brain alpha2- and beta-adrenoceptors are of interest in physiological (aging) and pathological (major depression) processes involving both receptors. In this study, total beta-adrenoceptors and beta1/2-subtypes were quantitated in postmortem human brains to investigate their relationships with alp...

journal_title：Brain research

authors： Sastre M,Guimón J,García-Sevilla JA

更新日期：2001-04-20 00:00:00

abstract：:The thalamic paraventricular nucleus (PVT) receives afferents from numerous brain areas, including the hypothalamic suprachiasmatic nucleus (SCN), considered to be the major circadian pacemaker. The PVT also sends projections to the SCN, limbic system centers and some nuclei involved in the control of the Sleep-Wake c...

journal_title：Brain research

authors： Nascimento ES Jr,Duarte RB,Silva SF,Engelberth RC,Toledo CA,Cavalcante JS,Costa MS

更新日期：2008-11-19 00:00:00

abstract：:The subunit composition of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) is an important determinant of AMPAR biophysical properties and trafficking. To date, AMPAR subunit composition has been quantitatively evaluated only for the hippocampus, where different experimental approaches have yield...

journal_title：Brain research

authors： Reimers JM,Milovanovic M,Wolf ME

更新日期：2011-01-07 00:00:00

abstract：:Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (micr...

journal_title：Brain research

authors： Reagan LP,Rosell DR,Alves SE,Hoskin EK,McCall AL,Charron MJ,McEwen BS

更新日期：2002-04-05 00:00:00

abstract：:Large neurons in the neostriatum of patients with Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) were investigated topographically, histologically and ultrastructurally. The number of large neurons whose nuclear area is greater than 101 microns2 was uniformly decreased in the neostriatum in PSP, but...

journal_title：Brain research

authors： Oyanagi K,Takahashi H,Wakabayashi K,Ikuta F

更新日期：1991-03-29 00:00:00

abstract：:Receptors for alpha-bungarotoxin are found on the surface of parasympathetic neurons in the frog cardiac ganglion by light microscopic autoradiography. Competition studies suggest that these receptors are cholinergic and indicate that they are also recognized by neuronal bungarotoxin (kappa-bungarotoxin). These recept...

journal_title：Brain research

authors： Sargent PB,Garrett EN

更新日期：1995-05-22 00:00:00

abstract：:The subthalamic nucleus plays a pivotal role in the regulation of basal ganglia output. Recent electrophysiologic, lesion and immunocytochemical studies suggest that the subthalamic nucleus uses an excitatory amino acid as a neurotransmitter. After complete ablation of the subthalamic nucleus, we have examined the NMD...

journal_title：Brain research

authors： Price RH Jr,Hollingsworth Z,Young AB,Penney JB Jr

更新日期：1993-01-29 00:00:00

abstract：:Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains assayed for changes in GABA-mediated chloride flux into brain membrane vesicles (microsacs). Concentration-dependent stimulation of chloride flux by GABA alone was not affected by th...

journal_title：Brain research

authors： Allan AM,Zhang X,Baier LD

更新日期：1992-08-21 00:00:00

abstract：:Electrophysiological studies on the entopedunculo- and cerebello-thalamic projections were performed by intracellular recordings in the thalamic VA, VL and VM nuclei of cats under sodium pentobarbital anesthesia. Identification of the thalamic neurons were performed electrophysiologically by antidromic activation on s...

journal_title：Brain research

authors： Yamamoto T,Noda T,Miyata M,Nishimura Y

更新日期：1984-06-03 00:00:00

abstract：:Using a perifusion culture technique, the pattern of vasopressin release from the suprachiasmatic nucleus was studied in vitro under basal and stimulated conditions. Individual rat suprachiasmatic explants released vasopressin in a rhythmic fashion and these rhythms persisted with a circadian period for up to 4 cycles...

journal_title：Brain research

authors： Earnest DJ,Sladek CD

更新日期：1987-10-06 00:00:00

abstract：:The effects of undernutrition during pregnancy and/or lactation periods on cortical structures have already been reported. However, its effect on non-cortical areas like the hypothalamic, that participates in the regulation of the autonomic nervous system or food intake, has not been extensively investigated. We studi...

journal_title：Brain research

authors： González-Pardo H,Gutiérrez-Sánchez JM,Menéndez-Patterson A,Arias JL

更新日期：1994-08-15 00:00:00

abstract：:Preconditioning-induced cellular adaptation is a new therapeutic strategy for ischemic stroke. This research aims to examine the role of peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α (PGC-1α) and hypoxia induced factor-1α (HIF-1α) in hypoxic preconditioning-induced protection. In this study, rat...

journal_title：Brain research

authors： Zhao J,Li L,Pei Z,Li C,Wei H,Zhang B,Peng Y,Wang Y,Tao Y,Huang R

更新日期：2012-04-04 00:00:00

abstract：:The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes. Experimental results (resection of the olfactory tracts or unilateral kainic acid administration in the telencephalon) suggest that: the projection from the ...

journal_title：Brain research

authors： Bissoli R,Contestabile A,Marotta L,Poli A,Migani P

更新日期：1985-10-07 00:00:00

abstract：:We have examined the soma diameters and distribution of catecholaminergic (CA) cells in human retinae, by using an antibody to tyrosine hydroxylase (TH), the rate limiting enzyme in the production of catecholamines. TH-immunoreactivity was detected in two classes of cells (CA1 and CA2 cells). CA1 cells had relatively ...

journal_title：Brain research

authors： Mitrofanis J,Provis JM

更新日期：1990-09-10 00:00:00

abstract：:A significant fall in the number of GABA-immunoreactive cells in laminae I-III of the rat spinal cord occurred in the somatotopic area of projection of the sciatic nerve after nerve transection. The decrease started at 2 weeks post-neurectomy, and at 4 weeks ipsilateral mean cell numbers were approximately 72% of cont...

journal_title：Brain research

authors： Castro-Lopes JM,Tavares I,Coimbra A

更新日期：1993-08-27 00:00:00

abstract：:By use of the push-pull perfusion technique, release of neuronal cholecystokinin-like immunoreactivity (CCK-LI) from hypothalamus of owl monkeys was investigated in relation to an intragastric meal. In overnight fasted, halothane-anesthetized owl monkeys, levels of CCK-LI in the hypothalamic push-pull perfusate were b...

journal_title：Brain research

authors： Schick RR,Reilly WM,Roddy DR,Yaksh TL,Go VL

更新日期：1987-08-18 00:00:00

abstract：:Social defeat is a powerful experience that often leads to drastic physiological and behavioral changes in many animal species. An example of such a change is conditioned defeat in Syrian hamsters. The neurophysiological mechanisms that underlie such changes are not yet fully understood, however, there is evidence tha...

journal_title：Brain research

authors： Jasnow AM,Huhman KL

更新日期：2001-11-30 00:00:00

abstract：:The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...

journal_title：Brain research

authors： Cintron AF,Dalal NV,Dooyema J,Betarbet R,Walker LC

更新日期：2015-10-05 00:00:00

abstract：:The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...

journal_title：Brain research

authors： Castelli L,Nigro MJ,Magistretti J

更新日期：2007-08-13 00:00:00

abstract：:Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding ...

journal_title：Brain research

authors： Kalus P,Braak H,Braak E,Bohl J

更新日期：1989-08-07 00:00:00

abstract：:Novel environments induce a conflicting emotional approach-withdrawal state that triggers stress-related reactions. Social support through the presence of a highly familiar conspecific buffers the individual against such challenges. Although aversive events seem to be predominantly processed by the right hemisphere, t...

journal_title：Brain research

authors： Pereira LC,Barros M

更新日期：2021-01-15 00:00:00