Abstract：
:Serotonin (5HT) systems play important roles in brain development, and early perturbations of 5HT receptor expression produce permanent changes in 5HT synaptic function and associated behaviors. We exposed pregnant Rhesus monkeys to environmental tobacco smoke (ETS) during gestation and for up to 3 months postnatally and examined the expression of 5HT(1A) and 5HT(2) receptors, and of the presynaptic 5HT transporter in brain regions containing 5HT projections (frontal, temporal and occipital cortex) and cell bodies (midbrain). Perinatal ETS exposure elicited upregulation of 5HT(1A) receptor expression without parallel changes in the other two proteins, a pattern consistent with specific 5HT receptor dysregulation, rather than universal disruption of 5HT synaptic development. The effects seen here for ETS in a primate model are virtually identical in direction, magnitude and regional selectivity to those obtained previously for prenatal nicotine administration in rats. Specifically, early 5HT(1A) overexpression alters the program for future synaptic and behavioral 5HT responses, thus providing a mechanistic link for the shared effects of ETS and nicotine on a specific pathway responsible for behavioral anomalies associated with perinatal tobacco exposure. These results reinforce the need to reduce ETS exposure of pregnant women and young children.
journal_name
Brain Resjournal_title
Brain researchauthors
Slotkin TA,Pinkerton KE,Tate CA,Seidler FJdoi
10.1016/j.brainres.2006.06.094subject
Has Abstractpub_date
2006-09-21 00:00:00pages
30-5issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)02006-3journal_volume
1111pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90184-7
更新日期：1984-11-12 00:00:00
abstract：:The relationship between the dorsal raphe neurons projecting to the caudate-putamen and those projecting to the substantia nigra was investigated using a fluorescent retrograde double labeling technique in the rat. The majority of the dorsal raphe neurons projecting to the substantia nigra were found to project also t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90250-4
更新日期：1980-03-17 00:00:00
abstract：:Fibrates are activators of peroxisome proliferator-activated receptor (PPAR) α. Pretreatment with fibrates has been shown to protect brain against ischemia in mice. We hypothesized that fibrates elevate superoxide dismutase (SOD) levels in the brain microvessels (BMVs). BMVs were isolated from male C57BL/6 and PPARα n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.075
更新日期：2010-11-04 00:00:00
abstract：:In the previous study, we reported increased NOS expression in the astrocytes in the spinal cord of the transgenic mice that are used as ALS animal model. In the present study, we performed immunocytochemical studies to investigate the changes of nitrotyrosine-immunoreactivity in the brains of the transgenic mice, and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02302-1
更新日期：2000-01-17 00:00:00
abstract：:Infrared differential interference contrast (IR DIC) videomicroscopy was used to measure and characterize cell swelling induced by activation of glutamate receptors (GluR) in a neostriatal brain slice preparation. This swelling is, in many cases, a prelude to necrotic cell death. Activation of N-methyl-D-aspartate (NM...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00323-x
更新日期：1996-06-17 00:00:00
abstract：:Ligation of CD27, a member of the tumor necrosis factor (TNF) receptor family, by its ligand CD70 is thought to be important in T cell activation, expansion and survival, B cell activation, and NK cell activation. We examined the role of CD70 in Theiler's murine encephalomyelitis virus-induced demyelinating disease (T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.058
更新日期：2010-03-04 00:00:00
abstract：:Fluoro-Jade B is known as a high affinity fluorescent marker for the localization of neuronal degeneration during acute neuronal distress. However, one study suggested that fluoro-Jade B stains reactive astroglia in the primate cerebral cortex. In this study, we analyzed the staining of fluoro-Jade B alone or combined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.050
更新日期：2007-01-12 00:00:00
abstract：:Lamprey retriculospinal neurons show phasic oscillations of their membrane potential during fictive locomotion. This modulation originates from the spinal cord locomotor networks. The aim of the present study was to elucidate the pattern of discharge of the spino-bulbar axons responsible for this modulation. Experimen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90327-6
更新日期：1992-06-05 00:00:00
abstract：:Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8-12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00329-1
更新日期：1998-06-08 00:00:00
abstract：:The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent mann...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91331-a
更新日期：1990-08-13 00:00:00
abstract：:In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicated in the Alzheimer׳s disease (AD)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.036
更新日期：2015-12-10 00:00:00
abstract：:Biochemical analysis of the binding of [125I]Bolton-Hunter coupled substance P [( 125I]BH-SP) to slide-mounted sections of rat brain demonstrated that [125I]BH-SP labels a binding site with a structure-activity profile characteristic of a substance P receptor. Under optimized preincubation and incubation conditions, t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91009-6
更新日期：1984-08-20 00:00:00
abstract：:Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90826-8
更新日期：1988-06-28 00:00:00
abstract：:The link between the immunolocalization of apolipoproteins E (apo E) and J (apo J) and the different severity of beta-amyloid deposition in various areas of Alzheimer's disease (AD) and Down's syndrome (DS) brain was analyzed. Both apolipoproteins were found in all types of senile plaques (SPs) in the cerebral cortex,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00482-6
更新日期：1995-07-10 00:00:00
abstract：:Parasympathetic innervation to eyelid smooth muscle inhibits sympathetic neurotransmission pre-junctionally without appreciable direct post-junctional effects. However, 5 weeks after sympathectomy, parasympathetic stimulation elicits substantial cholinergically mediated contractions. This study examined ultrastructura...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01439-x
更新日期：1998-03-09 00:00:00
abstract：:We evaluated the role of neuropeptide Y (NPY), a potent endogenous orexigenic signal, in the ventromedial hypothalamic (VMH) lesion-induced hyperphagia in rats. To produce hyperphagia and excessive weight gain, adult female rats received bilateral electrolytic or sham lesions in the VMH. Concurrently, a permanent intr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00644-6
更新日期：1995-09-04 00:00:00
abstract：:It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90234-5
更新日期：1989-08-28 00:00:00
abstract：:Mice of the BALB/c strain were bilaterally implanted with electrodes in the lateral entorhinal cortex (EC) in order to study the influence of post-trial EC stimulation on memory. The learning task was a food reinforced operant conditioning. At one of several time intervals after a first learning session, the experimen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91201-x
更新日期：1982-02-11 00:00:00
abstract：:The cytoplasmic adaptor protein Disabled-1 (Dab1), which is a key component of the Reelin-signaling pathway, has been suggested to be required for neuronal dendritic development. However, only data from studies on immature cultures [< or = 6 days in vitro (DIV)] and cytoarchitectural analyses of mutant mice have been ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.035
更新日期：2007-10-03 00:00:00
abstract：:Upon a physiological and pharmacological challenge, the responsiveness of extracellular glutamate levels in the prefrontal cortex, ventral tegmental area and locus coeruleus were studied using microdialysis. A 10-min handling period was used as a mild stressful stimulus. In all three brain areas, handling induced an i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01538-3
更新日期：1999-07-03 00:00:00
abstract：:Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02657-3
更新日期：2000-09-08 00:00:00
abstract：:The study examined whether intravenous (i.v.) leptin increased Fos-production in spinally projecting neurons in the hypothalamic paraventricular nucleus (PVN). We combined (i) rhodamine tagged microspheres injected into the upper thoracic spinal cord and (ii) Fos (marker of neuronal activation) immunohistochemistry. E...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01902-2
更新日期：1999-10-09 00:00:00
abstract：:L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.065
更新日期：2003-12-12 00:00:00
abstract：:Previous research has suggested the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in psychostimulant reinforcement. In particular, we have found significant correlations between electric footshock-induced increases in plasma corticosterone and the acquisition, or lack thereof, of intravenous c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00206-5
更新日期：1996-05-25 00:00:00
abstract：:Adrenergic innervation of tibial and vagus nerves was studied after 1-16 weeks duration of streptozotocin (STZ)-induced diabetes in rats. Sucrose-phosphate glyoxylic acid (SPG) histochemistry and the formaldehyde-induced fluorescence (FIF) method were used to demonstrate adrenergic nerve fibers in the epi-perineurial ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91095-x
更新日期：1990-04-09 00:00:00
abstract：:EEG recordings of hippocampal theta activity and neocortical activity were correlated with direct observations and photographic recordings of the behaviour of unrestrained cats. The behaviour studied included (1) both spontaneous and induced changes in level of arousal (sleep-wakefulness), (2) different types of orien...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90110-9
更新日期：1975-09-23 00:00:00
abstract：:Ibogaine, a naturally occurring iboga alkaloid, has been claimed to be effective in treating addiction to opioids and stimulants, and has been reported to inhibit morphine and cocaine self-administration in rats. However, ibogaine also has acute nonspecific side effects (e.g. tremors, decreased motivated behavior in g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00056-x
更新日期：1996-05-06 00:00:00
abstract：:Muscarinic and NMDA receptors contribute to post-traumatic hypersensitivity to secondary ischemia. However, the effect of these receptor antagonists on behavior and CA1 neuronal death after traumatic brain injury (TBI) with acute (1 h after TBI) forebrain ischemia has not been systematically assessed. We examined cogn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01237-2
更新日期：1999-01-30 00:00:00
abstract：:To identify thermosensitive areas of brain, we exposed rats to warm or cool environments and used the expression of the protein Fos as a marker of neuronal activity. In hyperthermic, heat-exposed rats, the median preoptic nucleus, and the medial and lateral preoptic areas had significantly more Fos immunoreactive neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91280-6
更新日期：1993-08-06 00:00:00
abstract：:A double-labeling immunofluorescence technique was employed to investigate the co-localization of the functionally antagonistic neuropeptides, substance P and enkephalins, within intraspinal neurons of the rat. Anti-Met-enkephalin-Arg6-Gly7-Leu8 (Enk-8) antiserum was used as a marker of the preproenkephalin A neuron s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90148-5
更新日期：1988-06-21 00:00:00
