Abstract:
:In most cases obesity, a major risk factor for diabetes mellitus type 2 and other associated chronic diseases, is generated by excessive eating. For a better understanding of eating behavior, it is necessary to determine how it is modulated by factors such as the calorie content of food, satiety and gender. Twelve healthy normal weighted participants (six female) were investigated in a functional magnetic resonance imaging (fMRI) study. In order to prevent the influence of social acceptability, an implicit one-back task was chosen for stimulus presentation. We presented food (high- and low-caloric) and non-food pictures in a block design and subjects had to indicate by button press whether two consecutive pictures were the same or not. Each subject performed the task in a hungry and satiated state on two different days. High-caloric pictures compared to low-caloric pictures led to increased activity in food processing and reward related areas, like the orbitofrontal and the insular cortex. In addition, we found activation differences in visual areas (occipital lobe), despite the fact that the stimuli were matched for their physical features. Detailed investigation also revealed gender specific effects in the fusiform gyrus. Women showed higher activation in the fusiform gyrus while viewing high-caloric pictures in the hungry state. This study shows that the calorie content of food pictures modulates the activation of brain areas related to reward processing and even early visual areas. In addition, satiation seems to influence the processing of food pictures differently in men and women. Even though an implicit task was used, activation differences could also be observed in the orbitofrontal cortex, known to be activated during explicit stimulation with food related stimuli.
journal_name
Brain Resjournal_title
Brain researchauthors
Frank S,Laharnar N,Kullmann S,Veit R,Canova C,Hegner YL,Fritsche A,Preissl Hdoi
10.1016/j.brainres.2010.04.030subject
Has Abstractpub_date
2010-09-02 00:00:00pages
159-66eissn
0006-8993issn
1872-6240pii
S0006-8993(10)00899-1journal_volume
1350pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distribut...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90993-9
更新日期:1978-11-17 00:00:00
abstract::The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.065
更新日期:2007-08-13 00:00:00
abstract::During the middle of the subjective day, circadian activity rhythms in Syrian hamsters can be phase advanced by a variety of stimuli including microinjection of neuropeptide Y (NPY) or muscimol into the suprachiasmatic nucleus (SCN). It is not known, however, if these treatments shift activity rhythms by acting direct...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00831-7
更新日期:1997-10-24 00:00:00
abstract::The single-unit activity of locus coeruleus noradrenergic (LC-NE) neurons was recorded in freely moving cats during naturally induced defense reactions. Defense reactions, consisting of arched back, piloerection, flattened ears and mydriasis, were elicited by exposing the cat either to a dog, or to a cat displaying ag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90773-5
更新日期:1990-10-29 00:00:00
abstract::The studies were performed on operation material from 17- to 63-year-old patients and on fetuses at 19-23 weeks gestational age. Formaldehyde histofluorescence showed the presence of numerous perivascular adrenergic nerves around pial and intracerebral vessels, the carotid system being better supplied than the vertebr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90356-5
更新日期:1976-10-22 00:00:00
abstract::Recent reports have identified discrepancies between the anatomical distribution of transmitters and their receptors, a phenomenon known as transmitter-receptor mismatch. However, quantitative determinations of transmitter activity and receptor density in individual brain regions have not been conducted in parallel. W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90038-8
更新日期:1988-06-14 00:00:00
abstract::In order to study the biosynthesis of myelin-associated proteins in Schwann cells, we have induced proliferation of cultured Schwann cells from neonatal rat sciatic nerve by transformation with Simian Virus 40 (SV40). Homogeneous transformed Schwann cell lines were established by single cell cloning. The transformed p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91324-2
更新日期:1987-06-23 00:00:00
abstract::The second of two targets (T2) presented in a rapid visual stream is often missed when presented shortly after the first (T1). This phenomenon has been referred to as the attentional blink. Here we show that the presentation of a synchronous sound enables T2 to escape the attentional blink, to the extent that performa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.070
更新日期:2008-11-25 00:00:00
abstract::Whole-cell patch-clamp recordings were used to investigate electrophysiological effects of neurotensin on acutely isolated dopaminergic (DA) neurons of the rat substantia nigra pars compacta (SNC). During current-clamp recordings, neurotensin depolarized DA neurons and triggered action potentials. Under voltage-clamp ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00379-5
更新日期:1995-06-19 00:00:00
abstract::Somatostatin receptors have been identified in different brain areas but the characterization of their postreceptor effect is still lacking. In this study we analyze the somatostatin effect on adenylate cyclase activity in different brain regions, namely frontal cortex, striatum, hypothalamus and hippocampus. Somatost...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90889-5
更新日期:1989-07-17 00:00:00
abstract::Rat cerebral cortex slices were incubated in small volumes of medium in order to study the bidirectional movements of gamma-aminobutyric acid (GABA) between tissue and medium, and to measure the extent of release of endogenous amino acids of interest as potential neurotransmitters. The apparent uptake, real uptake, an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90558-4
更新日期:1979-04-13 00:00:00
abstract::The expression of phosphorylated extracellular signal-regulated kinase 1/2 (pERK 1/2) was evaluated in the vestibular nuclei (VN) of rats following unilateral labyrinthectomy (UL). Immunohistochemistry revealed a significant asymmetrical increase in pERK 1/2 expression in the VN, 5 min after UL, after which pERK 1/2 i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.031
更新日期:2004-06-18 00:00:00
abstract::The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Population spikes were evoked by activation of Schaffer collaterals with a range of stimulation intensities. LTP was induced using θ-pattern primed burst...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02672-x
更新日期:2000-09-22 00:00:00
abstract::Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91081-3
更新日期:1993-10-22 00:00:00
abstract::Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91274-v
更新日期:1993-08-06 00:00:00
abstract::The transcription factor cAMP responsive element binding protein (CREB) is important in regulating immediate-early genes and some late-effector genes involved in neuroplasticity in response to peripheral injury and stressful insults. Partial nerve injury elicited neuropathic pain is accompanied by increased phosphoryl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03348-1
更新日期:2003-10-24 00:00:00
abstract::Transient ischemia increases tyrosine phosphorylation of N-methyl-D-aspartate (NMDA) receptor. Several tyrosine kinases are involved in this process. In this study, effect of ischemia and reperfusion (I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02619-1
更新日期:2001-08-03 00:00:00
abstract::Fetal exposure to diazepam (DZ), a positive modulator of GABA(A) receptors and an agonist at mitochondrial benzodiazine receptors, induces long-term neural and behavioral effects. This study evaluated whether the early manipulation influenced the normal development of brain levels of neurosteroids or altered steroid a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.039
更新日期:2006-01-05 00:00:00
abstract::Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03125-0
更新日期:2001-12-07 00:00:00
abstract::Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.014
更新日期:2009-08-11 00:00:00
abstract::Superior cervical ganglionectomy (SCGx) has drastic effects on numerous hormonal circadian rhythms and particularly on pineal melatonin secretion. We investigated the hormonal consequences of ablation of the superior cervical ganglion on the corticotropic circadian rhythms in the male rat. Plasma were obtained by samp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90237-2
更新日期:1994-08-01 00:00:00
abstract::To investigate the role of Ca2+ in astrocyte volume regulation, we determined Ca2+ fluxes following hypoosmotic stress and how these fluxes were modified by cyclic AMP. In isoosmotic conditions treatment with dibutyryl cyclic AMP (dBcAMP) caused almost a twofold increase in 45Ca2+ uptake. Efflux studies of 45Ca2+ in d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91634-9
更新日期:1994-05-09 00:00:00
abstract::The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain. We studied oxidative stress intensity (malondialdehyde (MDA) concentration) as wel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.11.062
更新日期:2012-01-30 00:00:00
abstract::Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.012
更新日期:2015-04-24 00:00:00
abstract::The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few sub...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91413-7
更新日期:1986-01-01 00:00:00
abstract::Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02610-x
更新日期:2000-09-01 00:00:00
abstract::Genetic abnormalities in amyloid precursor protein (APP) are associated with Down's syndrome and familial Alzheimer's disease where hallmark plaques contain A beta peptides derived from APP. Both APP and its derivatives are implicated in neurodegenerative processes and may play important physiological and pathophysiol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.09.024
更新日期:2008-12-03 00:00:00
abstract::To investigate to what extent the loss of cholinergic projections to the neocortex results in functional impairment in the target areas, local rates of cerebral glucose utilization were measured following excitotoxin lesions of the nucleus basalis magnocellularis (NBM) in the rat. Both unilateral and bilateral lesions...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90590-2
更新日期:1988-10-11 00:00:00
abstract::The pattern of generation of neurons in the albino rat superior colliculus has been studied in adult and fetal material. Neurons are generated between embryonic days 12 to 17, with rostrolateral colliculus in advance of caudomedial parts. More of the cells contributing to the deeper layers are generated early, while m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90004-0
更新日期:1979-03-23 00:00:00
abstract::The senescence-accelerated mouse prone 8 (SAMP8) is a novel aging model characterized by early onset and rapid advancement of senescence. In the present study, 6-month-old male SAMP8 mice were orally administered icariin (75, 150mg/kg) for 15weeks. Mice were submitted to passageway water maze test and step-down passiv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.084
更新日期:2010-06-02 00:00:00